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It has many influencing factors, but the specific etiology is not clear. MiRNA plays an important role in the fetal growth and development. In this article, we use TaqMan Low-Density Array to screen and analyze the differently expressed miRNAs in FGR-affected placenta (n\u2009=\u200940) and the normal placenta (n\u2009=\u200940). A total of 139 abnormally expressed miRNAs in the FGR-affected placenta were identified, and miR-1227-3p was the most highly downregulated miRNA. Importantly, miR-1227-3p may promote the proliferation in HTR-8\/SVneo cells, while inhibited the apoptosis of HTR-8\/SVneo cells. DAVID was used to analyze the pathway enrichment of target genes of miR-1227-3p to predict its mechanism of action. Furthermore, the putative targets of miR-1227-3p were predicted using the TargetScan, PicTar, DIANA LAB, and miRWalk database. The potential expression of target genes of miR-1227-3p, including <jats:italic>PRKAB2<\/jats:italic>, <jats:italic>AKT1<\/jats:italic>, <jats:italic>PIK3R3<\/jats:italic>, and <jats:italic>MKNK1<\/jats:italic> were significantly increased in FGR-affected placenta. Taken together, miR-1227-3p may participate in the development of FGR via regulating trophoblast cell proliferation and apoptosis by targeting genes involved in the insulin pathway. MiR-1227-3p may have a potential clinical value in the prevention and treatment of FGR, we need to study further to prove its value in the future.<\/jats:p>","DOI":"10.1038\/s41598-022-10127-w","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T10:31:09Z","timestamp":1650105069000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["miR-1227-3p participates in the development of fetal growth restriction via regulating trophoblast cell proliferation and apoptosis"],"prefix":"10.1038","volume":"12","author":[{"given":"Jiawen","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxing","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingjin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,16]]},"reference":[{"key":"10127_CR1","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3390\/genes11010080","volume":"11","author":"JL O'Callaghan","year":"2020","unstructured":"O\u2019Callaghan, J. 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