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Combined antiretroviral therapy (cART) has improved the health outcomes of many people living with HIV but has given rise to a less severe but limiting form of HAND. The study aimed to evaluate the impact of HAND on medication adherence, activities of daily living (ADL), quality of life and frailty. This systematic review adheres to the guidelines for Preferred Reporting Items for Systematic Reviews and Meta-Analyses. We searched MEDLINE, PubMed, CINAHL, Academic Search Complete, and PsycINFO online databases. Studies were included if they examined the relationship between HAND and medication adherence, ADL, quality of life and frailty, and were conducted between 1997 and 2021. We used a random-effects meta-analysis model to assess the impact of HAND on outcome variables. Forty papers, totaling 11,540 participants, were included in the narrative and quantitative syntheses. Cognitive impairment was associated with poorer medication adherence (r\u2009=\u20090.601, CI 0.338 to 0.776, <jats:italic>p<\/jats:italic>\u2009=\u20090.001, I<jats:sup>2<\/jats:sup>\u2009=\u200994.66). Cognitive impairment did not influence ADL (r\u2009=\u20090.167, CI-0.215 to 0.505, <jats:italic>p<\/jats:italic>\u2009=\u20090.393) and quality of life (r\u2009=\u20090.244, CI 0.117 to 0.548, <jats:italic>p<\/jats:italic>\u2009=\u20090.182). In the cART era, HAND appears to be associated with adherence to medication, which may influence future health outcomes. In PLWHIV who are adherent to cART, cognitive impairment does not appear to interfere with ADL and quality of life.<\/jats:p>","DOI":"10.1038\/s41598-022-10474-8","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T18:03:19Z","timestamp":1650391399000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Impact of HIV-associated cognitive impairment on functional independence, frailty and quality of life in the modern era: a meta-analysis"],"prefix":"10.1038","volume":"12","author":[{"given":"Martins","family":"Nweke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nombeko","family":"Mshunqane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini","family":"Govender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aderonke O.","family":"Akinpelu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryjane","family":"Ukwuoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"10474_CR1","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/jcom.12010","volume":"63","author":"K Greene","year":"2013","unstructured":"Greene, K., Carpenter, A., Catona, D. & Magsamen-Conrad, K. 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