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This prospective randomized controlled trial included patients undergoing placement procedures for peripherally inserted central venous catheters (PICC), ports and central venous catheters (CVC). Patients were randomly assigned to a music intervention group (MIG) and a control group (CTRL). State and trait anxiety levels were assessed as primary outcome using the state-trait anxiety inventory (STAI) before and after the procedures. Secondary outcomes comprised averaged heart rate for all participants and time of radiological surveillance for port placement procedures exclusively. 72 participants were included into the final analysis (MIG <jats:italic>n<\/jats:italic>\u2009=\u200940; CTRL <jats:italic>n<\/jats:italic>\u2009=\u200932). All procedures were successful and no major complications were reported. Mean levels for post-interventional anxieties were significantly lower in the MIG compared to the CTRL (34.9\u2009\u00b1\u20098.9 vs. 44\u2009\u00b1\u200912.1; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Mean heart rate in the MIG was significantly lower than in the CTRL (76.1\u2009\u00b1\u200913.7 vs. 93\u2009\u00b1\u20098.9; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Procedure time for port implantation was significantly longer in the MIG by 3\u00a0min 45\u00a0s (<jats:italic>p<\/jats:italic>\u2009=\u20090.031). Music exposure during central venous catheter placement procedures highly significantly reduces anxiety and stress levels and can be used to improve patients\u2019 overall experience in the angio suite.<\/jats:p>","DOI":"10.1038\/s41598-022-10862-0","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T09:03:47Z","timestamp":1651136627000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A prospective randomized controlled trial assessing the effect of music on patients\u2019 anxiety in venous catheter placement procedures"],"prefix":"10.1038","volume":"12","author":[{"given":"Florian Nima","family":"Fleckenstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes Klara","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Collettini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Frisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willie Magnus","family":"L\u00fcdemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Can","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Gebauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jonczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"10862_CR1","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/j.1440-1673.1995.tb00256.x","volume":"39","author":"CY Hiew","year":"1995","unstructured":"Hiew, C. 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