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A total of 1468 patients were analyzed. Tear break-up time (BUT) decreased continuously for five consecutive years: 4.76\u2009\u00b1\u20091.84\u00a0s in 2015, 4.57\u2009\u00b1\u20091.70\u00a0s in 2016 (p\u2009=\u20090.999, vs 2015), 4.35\u2009\u00b1\u20092.06\u00a0s in 2017 (p\u2009=\u20090.662), 3.83\u2009\u00b1\u20092.18\u00a0s in 2018 (p\u2009&lt;\u20090.001), and 3.63\u2009\u00b1\u20092.10\u00a0s in 2019 (p\u2009&lt;\u20090.001). The decrease of BUT was more prominent in women than men (p\u2009&lt;\u20090.001) and the correlation coefficient between calendar year and BUT was greater in women than men (p\u2009=\u20090.002). Schirmer test value, strip tear meniscometry value, and corneal staining score did not exhibit significant changes. Prevalence of blurring, photophobia, and pain increased toward 2019 among symptoms surveyed (eye fatigue, blurring, photophobia, dryness, irritation, and pain) and regression analysis indicated blurring (p\u2009&lt;\u20090.001), photophobia (p\u2009&lt;\u20090.001), and pain (p\u2009&lt;\u20090.001) were correlated with BUT. 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