{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T03:25:27Z","timestamp":1794540327211,"version":"4.9.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The project from the China-Japan friendship Hospital","award":["2014-4-MS-20"],"award-info":[{"award-number":["2014-4-MS-20"]}],"id":[{"id":"https:\/\/ror.org\/037cjxp13","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The project from the China-Japan friendship Hospital","award":["2014-4-MS-20"],"award-info":[{"award-number":["2014-4-MS-20"]}],"id":[{"id":"https:\/\/ror.org\/037cjxp13","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The project from the China-Japan friendship Hospital","award":["2014-4-MS-20"],"award-info":[{"award-number":["2014-4-MS-20"]}],"id":[{"id":"https:\/\/ror.org\/037cjxp13","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The project from the China-Japan friendship Hospital","award":["2014-4-MS-20"],"award-info":[{"award-number":["2014-4-MS-20"]}],"id":[{"id":"https:\/\/ror.org\/037cjxp13","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to compare the efficacy between decompression and drainage seton (DADS) and cutting seton (CS) in the treatment of high complex anal fistula. Patients were randomly assigned 1:1 to DADS or CS group. The primary outcome was the rate of wound healing. Second outcomes included time taken to return to work, postoperative pain, the severity of fecal incontinence and other complications. A total of 120 patients with a mean age of 39\u00a0years were included. There was no significant difference in the rate of complete wound healing at 1\u00a0year. The mean time taken to return to work was 5\u2009\u00b1\u20092\u00a0days in DADS group, shorter than CS group (10\u2009\u00b1\u20093,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Mean vaizey incontinence score and the post-operation pain in DADS group was significantly lower than CS group. No significant difference was found between two groups in the incidence of complications. DADS is as effective as Cutting seton for the treatment of high complex anal fistula but is associated with less postoperative pain and better sphincter function preserving.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-11712-9","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T07:03:10Z","timestamp":1652338990000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cutting seton versus decompression and drainage seton in the treatment of high complex anal fistula: a randomized controlled trial"],"prefix":"10.1038","volume":"12","author":[{"given":"Qiuxiang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lansi","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3879-7441","authenticated-orcid":false,"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"issue":"2","key":"11712_CR1","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s10151-019-02144-1","volume":"24","author":"A Amato","year":"2020","unstructured":"Amato, A. et al. Evaluation and management of perianal abscess and anal fistula: SICCR position statement. Tech. Coloproctol. 24(2), 127\u2013143. https:\/\/doi.org\/10.1007\/s10151-019-02144-1 (2020).","journal-title":"Tech. Coloproctol."},{"issue":"1","key":"11712_CR2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3748\/wjg.v21.i1.12","volume":"21","author":"E Limura","year":"2015","unstructured":"Limura, E. & Giordano, P. Modern management of anal fistula. World J. Gastroenterol. 21(1), 12\u201320. https:\/\/doi.org\/10.3748\/wjg.v21.i1.12 (2015).","journal-title":"World J. Gastroenterol."},{"issue":"4","key":"11712_CR3","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1159\/000342398","volume":"29","author":"G Subhas","year":"2012","unstructured":"Subhas, G. et al. Setons in the treatment of anal fistula: Review of variations in materials and techniques. Dig. Surg. 29(4), 292\u2013300. https:\/\/doi.org\/10.1159\/000342398 (2012).","journal-title":"Dig. Surg."},{"key":"11712_CR4","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1007\/s12262-018-1788-2","volume":"80","author":"P Garg","year":"2018","unstructured":"Garg, P. Garg classification for anal fistulas: Is it better than existing classifications?\u2014A review. Indian J. Surg. 80, 606\u2013608. https:\/\/doi.org\/10.1007\/s12262-018-1788-2 (2018).","journal-title":"Indian J. Surg."},{"issue":"7","key":"11712_CR5","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1111\/j.1365-2702.2005.01121.x","volume":"14","author":"A Williamson","year":"2005","unstructured":"Williamson, A. & Hoggart, B. Pain: A review of three commonly used pain rating scales. J. Clin. Nurs. 14(7), 798\u2013804. https:\/\/doi.org\/10.1111\/j.1365-2702.2005.01121.x (2005).","journal-title":"J. Clin. Nurs."},{"issue":"1","key":"11712_CR6","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1136\/gut.44.1.77","volume":"44","author":"CJ Vaizey","year":"1999","unstructured":"Vaizey, C. J., Carapeti, E., Cahill, J. A. & Kamm, M. A. Prospective comparison of faecal incontinence grading systems. Gut 44(1), 77\u201380. https:\/\/doi.org\/10.1136\/gut.44.1.77 (1999).","journal-title":"Gut"},{"issue":"5","key":"11712_CR7","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/codi.14504","volume":"21","author":"H Lin","year":"2019","unstructured":"Lin, H., Jin, Z., Zhu, Y., Diao, M. & Hu, W. Anal fistula plug vs rectal advancement flap for the treatment of complex cryptoglandular anal fistulas: A systematic review and meta-analysis of studies with long-term follow-up. Colorectal Dis. Off. J. Assoc. Coloproctol. Great Br. Ireland 21(5), 502\u2013515. https:\/\/doi.org\/10.1111\/codi.14504 (2019).","journal-title":"Colorectal Dis. Off. J. Assoc. Coloproctol. Great Br. Ireland"},{"issue":"4","key":"11712_CR8","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1007\/s00464-017-5905-2","volume":"32","author":"SH Emile","year":"2018","unstructured":"Emile, S. H., Elfeki, H., Shalaby, M. & Sakr, A. A Systematic review and meta-analysis of the efficacy and safety of video-assisted anal fistula treatment (VAAFT). Surg. Endosc. 32(4), 2084\u20132093. https:\/\/doi.org\/10.1007\/s00464-017-5905-2 (2018).","journal-title":"Surg. Endosc."},{"issue":"2","key":"11712_CR9","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.surg.2019.09.012","volume":"167","author":"SH Emile","year":"2020","unstructured":"Emile, S. H., Khan, S. M., Adejumo, A. & Koroye, O. Ligation of intersphincteric fistula tract (LIFT) in treatment of anal fistula: An updated systematic review, meta-analysis, and meta-regression of the predictors of failure. Surgery 167(2), 484\u2013492. https:\/\/doi.org\/10.1016\/j.surg.2019.09.012 (2020).","journal-title":"Surgery"},{"key":"11712_CR10","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.jss.2017.02.053","volume":"213","author":"SH Emile","year":"2017","unstructured":"Emile, S. H. et al. Predictive factors for recurrence of high transsphincteric anal fistula after placement of seton. J. Surg. Res. 213, 261\u2013268. https:\/\/doi.org\/10.1016\/j.jss.2017.02.053 (2017).","journal-title":"J. Surg. Res."},{"issue":"10 Suppl","key":"11712_CR11","doi-asserted-by":"publisher","first-page":"S37","DOI":"10.1007\/s10350-006-0736-6","volume":"49","author":"H Kurihara","year":"2006","unstructured":"Kurihara, H. et al. A new concept for the surgical anatomy of posterior deep complex fistulas: The posterior deep space and the septum of the ischiorectal fossa. Dis. Colon Rectum 49(10 Suppl), S37\u2013S44. https:\/\/doi.org\/10.1007\/s10350-006-0736-6 (2006).","journal-title":"Dis. Colon Rectum"},{"issue":"8","key":"11712_CR12","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1097\/DCR.0000000000000628","volume":"59","author":"H Zhang","year":"2016","unstructured":"Zhang, H. et al. 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Clinical effect of tunnel-like fistulectomy plus draining seton combined with incision of internal opening of anal fistula (TFSIA) in the treatment of high trans-sphincteric anal fistula. Med. Sci. Monit. Int. Med. J. Exp. Clin. Res. 26, e918228. https:\/\/doi.org\/10.1265\/MSM.918228 (2020).","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"11712_CR15","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.ijsu.2019.11.008","volume":"72","author":"M Abdelnaby","year":"2019","unstructured":"Abdelnaby, M., Emile, S., El-Said, M., Abdallah, E. & AbdelMawla, A. Drained mucosal advancement flap versus rerouting Seton around the internal anal sphincter in treatment of high trans-sphincteric anal fistula: A randomized trial. Int. J. Surg. (London, England) 72, 198\u2013203. https:\/\/doi.org\/10.1016\/j.ijsu.2019.11.008 (2019).","journal-title":"Int. J. Surg. 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Saudi Med."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-11712-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-11712-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-11712-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T21:40:51Z","timestamp":1669326051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-11712-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,12]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["11712"],"URL":"https:\/\/doi.org\/10.1038\/s41598-022-11712-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,12]]},"assertion":[{"value":"7 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7838"}}