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A\u00a0qualitative analysis\u00a0was conducted of all\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    -DMT experiences posted to the r\/DMT Reddit community over a 10-year period from 2009 to 2018. A total of 3778 experiences from 3305 posts were included in this study. A median dose of\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    -DMT of 40.0\u00a0mg [interquartile range (IQR), 27.5 to 50.0] and a median experience duration of 10\u00a0min (IQR, 5.0 to 15.0) were identified. The most common somatic effects were somaesthesias (n\u2009=\u20091415, 37.5%) and an auditory ringing (n\u2009=\u2009583, 15.4%). Visualizations predominantly consisted of fractals, shapes, patterns (n\u2009=\u20091231, 32.6%) and vivid colours (n\u2009=\u2009953, 25.2%). Entity encounters were reported in 45.5% (n\u2009=\u20091719) of the experiences and involved predominantly a feminine phenotype (n\u2009=\u2009416, 24.2%); deities (n = 293, 17.0%); aliens (n\u2009=\u2009281, 16.3%); creature-based entities (n\u2009=\u2009158, 9.2%, including reptilian and insectoid beings); mythological beings (n\u2009=\u2009144, 8.4%, including machine elves); and jesters (n\u2009=\u2009112, 6.5%). Entity interactions were predominantly positive (n\u2009=\u2009600, 34.9% of encounters) involving benevolent, comforting, protecting, or outwardly caring interactions. A companion-type, pedagogical, or guide-type interaction was identified 32.4% of encounters (n\u2009=\u2009557). Common typology, architecture, and structural features of the \u201cDMT world\u201d included descriptions of alternate or higher dimensions (n\u2009=\u2009952, 25.2%); rooms [n\u2009=\u2009582, 15.4%, including the \u201cwaiting room\u201d (n\u2009=\u2009105, 2.8%)], and a tunnel (n\u2009=\u2009390, 10.3%). Features of mystical and ego-dissolution experiences were common. Additional rewarding aspects were identified, including a sense of\u00a0familiarity and the\u00a0acceptance\/removal of the fear of death. Challenging and difficult responses were less frequent but also documented. Statements of profundity were identified in 232 experiences (6.1%), including pronouncing the experience or an aspect of the experience as the most \u201cbeautiful\u201d or feeling the most \u201cbeautiful\u201d of their life (n\u2009=\u200947, 1.2%). This study identified common phenomenological themes and content of naturalistic inhaled\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    -DMT experiences. Major thematic domains included (1) physical and somatic experiences; (2)\u00a0visualizations and imagery; (3) entity encounters including entity phenotype, descriptors, attributes, disposition, and characteristics of the interaction; (4) typology, architectural features, structural characteristics, and scenery of the \u201cDMT world\u201d; (5) alerations in consciousness (including mystical experiences, out-of-body experiences, and ego-dissolution);\u00a0(6) emotional responses (including positive, rewarding, difficult, and challenging); and (7) statements of profundity.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-11999-8","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T06:02:46Z","timestamp":1653372166000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Phenomenology and content of the inhaled N, N-dimethyltryptamine (N, N-DMT) experience"],"prefix":"10.1038","volume":"12","author":[{"given":"David Wyndham","family":"Lawrence","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Carhart-Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Timmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,24]]},"reference":[{"key":"11999_CR1","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1016\/0024-3205(84)90436-3","volume":"35","author":"RA Glennon","year":"1984","unstructured":"Glennon, R. 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