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Rasch-scaled scores of the Emotional well-being Mobility and Reading subscales of the Impact of Vision Impairment (IVI) questionnaire, collectively referred to as \u201cVRQoL\u201d were assessed. Multivariable linear regression analyses and pairwise comparisons adjusting for age, gender, ethnicity, socio-economic status, BMI, smoking, alcohol use, presence of systemic diseases and presenting VI were performed to assess and compare the impact of the presence and severity of each eye condition on the three IVI domains. Multivariable adjusted pairwise comparisons of VRQoL between early stages of the four eye diseases showed no significant differences (all P\u2009&gt;\u20090.05). For late stage diseases, individuals with VTDR had significantly larger decrements in Emotional well-being compared to glaucoma (\u03b2 \u2212 0.81; 95% CI \u2212 1.47 to \u2212 0.16) and MMD (\u03b2 \u2212 1.17; 95% CI \u2212 2.16 to \u2212 0.18); and Reading decrements compared to glaucoma (\u03b2 \u2212 0.66; 95% CI \u2212 1.22 to \u2212 0.11). When compared to late glaucoma, individuals with late AMD (\u03b2 \u2212 0.76; 95% CI \u2212 1.50 to \u2212 0.01) had significantly larger IVI Mobility subscale decrements. VTDR and late AMD, appear to have the greatest impact on VRQoL, compared to late glaucoma and MMD, suggesting a differential impact of late-stage eye disease categorization on VRQoL.<\/jats:p>","DOI":"10.1038\/s41598-022-12425-9","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T14:03:50Z","timestamp":1652969030000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Different impact of early and late stages irreversible eye diseases on vision-specific quality of life domains"],"prefix":"10.1038","volume":"12","author":[{"given":"Preeti","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva K.","family":"Fenwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan E. 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