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Improving control techniques requires a better understanding of the mosquito\u2019s life cycle, including spatial population dynamics in endemic regions. One of the most promising techniques consists of introducing genetically modified male mosquitoes. Several models proposed to describe this technique present mathematical issues or rely on numerous parameters, making their application challenging to real-world situations. We propose a model describing the spatial population dynamics of the <jats:italic>Aedes aegypti<\/jats:italic> in the presence of genetically modified males. This model presents some mathematical improvements compared to the literature allowing deeper mathematical analysis. Moreover, this model relies on few parameters, which we show how to obtain or estimate from the literature. Through numerical simulations, we investigate the impacts of environmental heterogeneity, the periodicity of genetically modified male releases, and released genetically modified males quantity on the population dynamics of <jats:italic>Aedes aegypti<\/jats:italic>. The main results point to that the successful application of this vector control technique relies on releasing more than a critical amount of modified males with a frequency exceeding a specific critical value.<\/jats:p>","DOI":"10.1038\/s41598-022-12764-7","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T10:02:55Z","timestamp":1654077775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Modeling the impact of genetically modified male mosquitoes in the spatial population dynamics of Aedes aegypti"],"prefix":"10.1038","volume":"12","author":[{"given":"Monalisa R.","family":"da Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro H. 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