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Although glucagonoma is usually accompanied by a variety of characteristic clinical symptoms, early diagnosis is still difficult due to the scarcity of the disease. In this study, we present the cumulative experiences, clinical characteristics and treatments of seven patients diagnosed with glucagonoma during the past 10\u00a0years at the First Affiliated Hospital of Xi\u2019an Jiaotong University. The seven patients in our cohort consisted of six females and one male with an average diagnosis age of 40.1\u00a0years (range 23\u201351). The average time from onset of symptoms to diagnosis of glucagonoma was 14\u00a0months (range 2\u201336\u00a0months). All the patients visited dermatology first for necrolytic migratory erythema (NME) 7\/7 (100%), and other presenting symptoms included diabetes mellitus (DM) 4\/7 (57%), stomatitis 2\/7 (28%), weight loss 4\/7 (57%), anemia 4\/7 (57%), diarrhea 1\/7 (14%), and DVT1\/7 (14%). Plasma glucagon levels were increased in all patients (range 216.92\u20133155\u00a0pg\/mL) and declined after surgery. Imaging studies revealed that four of seven patients had liver metastasis. Six of seven patients received surgical resection, and all of them received somatostatin analog therapy. Symptoms improved significantly in 6 out of 7 patients. Three of seven patients died of this disease by the time of follow-up. Our data suggest that if persistent NME is associated with DM and high glucagon levels, timely abdominal imaging should be performed to confirm glucagonoma. Once diagnosed, surgery and somatostatin analogs are effective for symptom relief and tumor control.<\/jats:p>","DOI":"10.1038\/s41598-022-12882-2","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T10:03:42Z","timestamp":1653991422000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Necrolytic migratory erythema is an important visual cutaneous clue of glucagonoma"],"prefix":"10.1038","volume":"12","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yina","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunbin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"issue":"4","key":"12882_CR1","doi-asserted-by":"publisher","first-page":"e2019129","DOI":"10.4322\/acr.2019.129","volume":"9","author":"M Cunha-Silva","year":"2019","unstructured":"Cunha-Silva, M. et al. 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