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However, IH remains underdiagnosed and inaccurately treated despite colossal social, professional and personal impacts. The pathogenesis of IH is poorly known, but recent works have suggested possible alterations of phototransduction. In this context, to identify biomarkers of IH, we studied the Post-Illumination Pupil Response (PIPR) using a specific pupillometry protocol reflecting the melanopsin-mediated pupil response in IH patients with prolonged total sleep time (TST\u2009&gt;\u2009660\u00a0min) and in healthy subjects. Twenty-eight patients with IH (women 86%, 25.4\u00a0year-old\u2009\u00b1\u20094.9) and 29 controls (women 52%, 27.1\u00a0year-old\u2009\u00b1\u20093.9) were included. After correction on baseline pupil diameter, the PIPR was compared between groups and correlated to sociodemographic and sleep parameters. We found that patients with IH had a lower relative PIPR compared to controls (32.6\u2009\u00b1\u20099.9% vs 38.5\u2009\u00b1\u200910.2%, p\u2009=\u20090.037) suggesting a reduced melanopsin response. In addition, the PIPR was not correlated to age, chronotype, TST, nor depressive symptoms. The melanopsin-specific PIPR may be an innovative trait marker of IH and the pupillometry might be a promising tool to better characterize hypersomnia.<\/jats:p>","DOI":"10.1038\/s41598-022-13041-3","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T15:04:04Z","timestamp":1653923044000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time"],"prefix":"10.1038","volume":"12","author":[{"given":"H\u00e9lo\u00efse","family":"Rach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulker","family":"Kilic-Huck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Reynaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Hugueny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Peiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Roy de Belleplaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Bourgin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre A.","family":"Geoffroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"13041_CR1","volume-title":"International Classification of Sleep Disorders (ICSD-3)","author":"American Academy of Sleep Medicine","year":"2014","unstructured":"American Academy of Sleep Medicine. 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