{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:37:37Z","timestamp":1792978657295,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We aimed\u00a0to investigate the diagnostic utility\u00a0of MRI extracellular volume fraction (ECV) for the assessment of liver cirrhosis severity as defined by Child\u2013Pugh class. In this retrospective study, 90 patients (68 cirrhotic patients and 22 controls), who underwent multiparametric liver MRI, were identified. Hepatic T1 relaxation times and ECV were assessed. Clinical scores of liver disease severity were calculated. One-way analysis of variance (ANOVA) followed by Tukey\u2019s multiple comparison test, Spearman\u2019s correlation coefficient, and receiver operating characteristic (ROC) analysis were used for statistical\u00a0analysis. In cirrhotic patients, hepatic native T1 increased depending on Child\u2013Pugh class (620.5\u2009\u00b1\u200978.9\u00a0ms (Child A) vs. 666.6\u2009\u00b1\u200973.4\u00a0ms (Child B) vs. 828.4\u2009\u00b1\u200991.2\u00a0ms (Child C),\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). ECV was higher in cirrhotic patients compared to the controls (40.1\u2009\u00b1\u200911.9% vs. 25.9\u2009\u00b1\u20094.5%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001) and increased depending of Child\u2013Pugh class (33.3\u2009\u00b1\u20096.0% (Child A) vs. 39.6\u2009\u00b1\u20094.9% (Child B) vs. 52.8\u2009\u00b1\u20091.2% (Child C),\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). ECV correlated with Child\u2013Pugh score (r\u2009=\u20090.64,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). ECV allowed differentiating between Child\u2013Pugh classes A and B, and B and C with an AUC of 0.785 and 0.944\u00a0(\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001, respectively). The diagnostic performance of ECV for differentiating between Child\u2013Pugh classes A and B, and B and C was higher compared to hepatic native T1 (AUC: 0.651 and 0.910) and MELD score (AUC: 0.740 and 0.795)\u00a0(\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05, respectively). MRI-derived\u00a0ECV correlated with Child\u2013Pugh score and\u00a0had a high diagnostic performance for the\u00a0discrimination of different\u00a0Child\u2013Pugh classes. ECV might become a valuable non-invasive biomarker for the assessment of liver cirrhosis severity.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-13340-9","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T06:03:24Z","timestamp":1654668204000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Assessment of liver cirrhosis severity with extracellular volume fraction MRI"],"prefix":"10.1038","volume":"12","author":[{"given":"Narine","family":"Mesropyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick A.","family":"Kupczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leona","family":"Dold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Praktiknjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Isaak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Endler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitrij","family":"Kravchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon M.","family":"Bischoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alois M.","family":"Sprinkart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus C.","family":"Pieper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kuetting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike I.","family":"Attenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian A.","family":"Luetkens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"13340_CR1","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.jhep.2012.12.005","volume":"58","author":"M Blachier","year":"2013","unstructured":"Blachier, M., Leleu, H., Peck-Radosavljevic, M., Valla, D.-C. & Roudot-Thoraval, F. 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