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Progression versus non-progression was defined based on changes in Quantitative Modified HRCT scores and PFTs over time. Specific serum protein biomarkers were assessed in serum samples at baseline and Year 5 by Multiplex enzyme-linked immunosorbent assays (ELISAs). At Year 5, 32% of patients demonstrated progressive RA-ILD, 35% were stable, and 33% improved. Baseline age and rheumatoid factor (RF) were significantly different between RA-ILD outcomes of progression vs. no-progression (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Changes in levels of CXCL11\/I-TAC and MMP13 over 5\u00a0years also distinguished pulmonary outcomes (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). A final binary logistic regression model revealed that baseline age and changes in serum MMP13 as well as CXCL11\/I-TAC were associated with RA-ILD progression at Year 5 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), with an AUC of 0.7772. 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