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We tested the hypothesis that spatiotemporal clustering of homotypic dengue cases is disrupted by introduction of the arbovirus-blocking bacterium\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    (\n                    <jats:italic>w<\/jats:italic>\n                    Mel-strain) into the\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    mosquito population. We analysed 318 serotyped and geolocated dengue cases (and 5921 test-negative controls) from a randomized controlled trial in Yogyakarta, Indonesia of\n                    <jats:italic>w<\/jats:italic>\n                    Mel deployments. We find evidence of spatial clustering up to 300\u00a0m among the 265 dengue cases (3083 controls) in the untreated trial arm. Participant pairs enrolled within 30\u00a0days and 50\u00a0m had a 4.7-fold increase (compared to 95% CI on permutation-based null distribution: 0.1, 1.2) in the odds of being homotypic (i.e. potentially transmission-related) as compared to pairs occurring at any distance. In contrast, we find no evidence of spatiotemporal clustering among the 53 dengue cases (2838 controls) resident in the\n                    <jats:italic>w<\/jats:italic>\n                    Mel-treated arm. Introgression of\n                    <jats:italic>w<\/jats:italic>\n                    Mel\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    into\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    mosquito populations interrupts focal dengue virus transmission leading to reduced case incidence; the true intervention effect may be greater than the 77% efficacy measured in the primary analysis of the Yogyakarta trial.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-13749-2","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T12:37:31Z","timestamp":1655210251000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Disruption of spatiotemporal clustering in dengue cases by wMel Wolbachia in Yogyakarta, Indonesia"],"prefix":"10.1038","volume":"12","author":[{"given":"Suzanne M.","family":"Dufault","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie K.","family":"Tanamas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Citra","family":"Indriani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi","family":"Utarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riris Andono","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas P.","family":"Jewell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron P.","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine L.","family":"Anders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"13749_CR1","doi-asserted-by":"publisher","unstructured":"Bhatt, S. et al. 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