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After the inoculation of <jats:italic>A. muciniphila<\/jats:italic> in brain heart infusion enriched medium, OMVs and cell-free supernatant were extracted. For the investigation of the effects of bacteria and its derivatives on the expression of ECS and <jats:italic>PPARs<\/jats:italic> genes, the aforementioned cells were treated by active and heat-inactivated bacteria, OMVs, and cell-free supernatant. Quantitative real-time polymerase chain reaction analysis revealed that both forms of the bacterium, bacterial-derived OMVs, and cell-free supernatant could affect the expression of <jats:italic>CB1<\/jats:italic>, <jats:italic>CB2<\/jats:italic>, <jats:italic>FAAH<\/jats:italic>, and <jats:italic>PPARs<\/jats:italic> genes (i.e., <jats:italic>\u03b1, \u03b2\/\u03b4, and \u03b4<\/jats:italic>) significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Considering the engagement of the aforementioned genes in metabolic pathways, it might be suggested that both forms of the bacterium, OMVs, and cell-free supernatant might have the potential to serve as a probiotic, paraprobiotic, and postbiotic candidate to prevent obesity, metabolic disorders, and liver diseases.\n<\/jats:p>","DOI":"10.1038\/s41598-022-13840-8","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T19:39:23Z","timestamp":1655321963000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effects of active, inactive, and derivatives of Akkermansia muciniphila on the expression of the endocannabinoid system and PPARs genes"],"prefix":"10.1038","volume":"12","author":[{"given":"Farinaz","family":"Ghaderi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fattah","family":"Sotoodehnejadnematalahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Hajebrahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl","family":"Fateh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Davar","family":"Siadat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"13840_CR1","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.3389\/fmicb.2017.01749","volume":"8","author":"C Ferrario","year":"2017","unstructured":"Ferrario, C. et al. 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