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Laser speckle flowgraphy of ONH and PPA was performed at baseline and at 1, 3, and 6\u00a0months postoperatively. The waveforms of the mean blur rate in the tissue area (MT) in the temporal ONH, \u03b2PPA (with Bruch\u2019s membrane), and \u03b3PPA (without Bruch\u2019s membrane) were evaluated. Mean intra-ocular pressure (IOP) decreased from 19.1\u2009\u00b1\u20090.8 to 8.5\u20139.6\u2009\u00b1\u20090.7\u00a0mmHg at postoperative visits. The average MT in the \u03b2PPA region increased significantly at all postoperative time points, whereas those in the ONH and \u03b3PPA regions remained unchanged. The blowout score (BOS) increased significantly, and the resistivity index decreased significantly at all time points in all regions, which was associated with decreased IOP. The current study showed two novel findings: MT increased after trabeculectomy only in \u03b2PPA, where the choroid was present. IOP decrease-associated BOS increase occurred postoperatively in all regions, which indicates that IOP reduction may decrease vascular transmural pressure and contribute to stable blood flow uniformly, despite structural differences between the regions.<\/jats:p>","DOI":"10.1038\/s41598-022-13989-2","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T15:30:44Z","timestamp":1655134244000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Waveform changes of laser speckle flowgraphy in the temporal optic nerve head and peripapillary atrophy after trabeculectomy in open-angle glaucoma"],"prefix":"10.1038","volume":"12","author":[{"given":"Makoto","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Higashide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Takeshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Takamatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Manbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Udagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,13]]},"reference":[{"issue":"5","key":"13989_CR1","first-page":"908","volume":"30","author":"JB Jonas","year":"1989","unstructured":"Jonas, J. 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