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We aimed to evaluate the association of PVCs during recovery with echocardiographic abnormalities, and their combined prognostic performance. Echocardiographic abnormalities [reduced left ventricular (LV) ejection fraction, valvular heart disease, LV dilatation, LV hypertrophy, or increased filling pressures] and PVCs during recovery were identified among patients having undergone both echocardiography and exercise stress test. Among included patients (n\u2009=\u20093106, age 59\u2009\u00b1\u200916\u00a0years, 55% males), PVCs during recovery were found in 1327 (43%) patients, among which the prevalence of echocardiographic abnormalities was increased (58% vs. 43%, p\u2009&lt;\u20090.001). Overall, PVCs during recovery were associated with increased cardiovascular mortality (219 total events, 7.9 [5.4\u201311.1] years follow-up; adjusted hazard ratio (HR [95% confidence interval]) 1.6 [1.2\u20132.1], p\u2009&lt;\u20090.001). When analyzed in combination with either presence or absence of\u00a0echocardiographic abnormalities, PVCs during recovery were associated with increased risk when such were present (HR 3.3 [1.9\u20135.5], p\u2009&lt;\u20090.001) but not when absent (HR 1.5 [0.8\u20132.8], p\u2009=\u20090.22), in reference to those with neither. Our findings provide mechanistic insights to the increased CV risk reported in patients with PVCs during recovery.<\/jats:p>","DOI":"10.1038\/s41598-022-14535-w","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T13:03:19Z","timestamp":1655470999000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prognostic implications of structural heart disease and premature ventricular contractions in recovery of exercise"],"prefix":"10.1038","volume":"12","author":[{"given":"Thomas","family":"Lindow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Brudin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristofer","family":"Hedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Ugander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"issue":"9","key":"14535_CR1","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1056\/NEJMoa022353","volume":"348","author":"JP Frolkis","year":"2003","unstructured":"Frolkis, J. 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