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Lipopolysaccharide (LPS)-induced injury is a valuable murine model of ALI but there is a paucity of data on lung regeneration and the role of angiogenic signaling involving vascular endothelial growth factor (VEGF). Eight-week-old male C57BL\/6J mice were randomized to receive intratracheal instillation of either LPS or isovolumetric phosphate buffered saline as a vehicle control. Mice were observed at a single follow-up time-point that was either short-term (24\u00a0h or 4\u00a0days) or long-term (7\u00a0days or 4\u00a0weeks). On pulmonary function testing, LPS-treated mice had increased compliance at 4\u00a0weeks post-instillation, which correlated with decreased vascularization and with time-dependent, progressive decrease in alveolarization. Treadmill exercise tolerance testing demonstrated impaired performance at 24\u00a0h, 4\u00a0days and 4\u00a0weeks following LPS exposure. On lung protein analysis, LPS instillation decreased VEGF expression at up to 4\u00a0weeks, and decreased activation of its key receptor, VEGFR2 at 7\u00a0days and 4\u00a0weeks post-instillation. Together, these data provide insight on long-term pulmonary functional outcomes 4\u00a0weeks after ALI and identify angiogenic proteins as possible therapeutic targets following lung injury.<\/jats:p>","DOI":"10.1038\/s41598-022-14618-8","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T10:09:12Z","timestamp":1655460552000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Lipopolysaccharide-induced murine lung injury results in long-term pulmonary changes and downregulation of angiogenic pathways"],"prefix":"10.1038","volume":"12","author":[{"given":"S. T.","family":"Tsikis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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