{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:05:30Z","timestamp":1793037930177,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Natural Science Foundation of Hunan Province of China","award":["2021JJ31103"],"award-info":[{"award-number":["2021JJ31103"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the surgical outcomes of pars plana vitrectomy (PPV) combined with inverted multi-layer internal limiting membrane (ILM) flap for the treatment of macular hole retinal detachment in high myopia. We retrospectively analysed the medical records of macular hole retinal detachment (MHRD) patients with high myopia. The patients were divided into two groups with different surgical procedure: inverted multi-layer ILM flap group (group 1, 27 eyes) and the ILM peeling group (group 2, 29 eyes). Retinal reattachment rate, macular hole closure rate at last follow-up and BCVA at 6\u00a0months post-operation were compared between the two groups. After primary PPV and silicone oil removal, the retinal reattachment rate was 96.3% in group 1 and 93.1% in group 2 respectively at last follow-up, showing no statistically significant difference (odds ratio\u2009=\u20090.525, <jats:italic>P<\/jats:italic>\u2009=\u20091.000). All eyes in group 1 had type I macular closure (100%, 27\/27), while only 7 eyes (24.1%, 7\/29) in group 2 have type I macular hole closure. The difference was statistically significant (odds ratio\u2009=\u20090, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The mean logMAR BCVA both improved significantly at 6\u00a0months post-operation compared with pre-operation (t\u2009=\u20094.181, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; t\u2009=\u20093.217, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), however the difference of post-operation BCVA between the two groups was not statistically significant (t\u2009=\u20090.906, <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). PPV combined with inverted multi-layer ILM flap could achieve better anatomical outcomes than ILM peeling technique with no significant advantage in functional outcomes.\n<\/jats:p>","DOI":"10.1038\/s41598-022-14716-7","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T18:03:01Z","timestamp":1655920981000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Inverted multi-layer internal limiting membrane flap for macular hole retinal detachment in high myopia"],"prefix":"10.1038","volume":"12","author":[{"given":"Xianggui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhuo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"issue":"5","key":"14716_CR1","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.survophthal.2021.02.010","volume":"66","author":"I Chatziralli","year":"2021","unstructured":"Chatziralli, I., Machairoudia, G., Kazantzis, D., Theodossiadis, G. & Theodossiadis, P. Inverted internal limiting membrane flap technique for myopic macular hole: A meta-analysis. Surv. Ophthalmol. 66(5), 771\u2013780. https:\/\/doi.org\/10.1016\/j.survophthal.2021.02.010 (2021).","journal-title":"Surv. Ophthalmol."},{"issue":"6","key":"14716_CR2","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1007\/s00417-017-3614-0","volume":"255","author":"T Kinoshita","year":"2017","unstructured":"Kinoshita, T., Onoda, Y. & Maeno, T. Long-term surgical outcomes of the inverted internal limiting membrane flap technique in highly myopic macular hole retinal detachment. Graefes. Arch. Clin. Exp. Ophthalmol. 255(6), 1101\u20131106. https:\/\/doi.org\/10.1007\/s00417-017-3614-0 (2017).","journal-title":"Graefes. Arch. Clin. Exp. Ophthalmol."},{"issue":"6","key":"14716_CR3","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/j.ophtha.2009.01.003","volume":"116","author":"X Li","year":"2009","unstructured":"Li, X., Wang, W., Tang, S. & Zhao, J. Gas injection versus vitrectomy with gas for treating retinal detachment owing to macular hole in high myopes. Ophthalmology 116(6), 1182\u201387.e1. https:\/\/doi.org\/10.1016\/j.ophtha.2009.01.003 (2009).","journal-title":"Ophthalmology"},{"issue":"2","key":"14716_CR4","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/s0002-9394(03)00186-7","volume":"136","author":"M Ichibe","year":"2003","unstructured":"Ichibe, M. et al. Surgical management of retinal detachment associated with myopic macular hole: Anatomic and functional status of the macula. Am. J. Ophthalmol. 136(2), 277\u2013284. https:\/\/doi.org\/10.1016\/s0002-9394(03)00186-7 (2003).","journal-title":"Am. J. Ophthalmol."},{"issue":"1","key":"14716_CR5","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.ophtha.2013.08.033","volume":"121","author":"LS Lim","year":"2014","unstructured":"Lim, L. S. et al. Prognostic factor analysis of vitrectomy for retinal detachment associated with myopic macular holes. Ophthalmology 121(1), 305\u2013310. https:\/\/doi.org\/10.1016\/j.ophtha.2013.08.033 (2014).","journal-title":"Ophthalmology"},{"issue":"6","key":"14716_CR6","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.ajo.2006.07.056","volume":"142","author":"RF Lam","year":"2006","unstructured":"Lam, R. F. et al. Pars plana vitrectomy and perfluoropropane (C3F8) tamponade for retinal detachment due to myopic macular hole: A prognostic factor analysis. Am. J. Ophthalmol. 142(6), 938\u2013944. https:\/\/doi.org\/10.1016\/j.ajo.2006.07.056 (2006).","journal-title":"Am. J. Ophthalmol."},{"key":"14716_CR7","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.ajo.2016.03.053","volume":"166","author":"SN Chen","year":"2016","unstructured":"Chen, S. N. & Yang, C. M. 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