{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T20:25:56Z","timestamp":1769027156911,"version":"3.49.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Blood pressure is maintained by a combined mechanism of the baroreceptor reflex and the vestibulosympathetic reflex. This study is intended to verify the hypothesis that the orthostatic hypotension (OH) seen when benign paroxysmal positional vertigo (BPPV) occurred may act as a factor that affects the recurrence of BPPV. The subjects of present study were selected from among 239 patients diagnosed with idiopathic BPPV. The average age of the group with OH was 59.3\u00a0years, and the age of the group without OH was 50.3\u00a0years, with a statistically significant difference (P\u2009=\u20090.013). It was shown that drug-taking increased the risk of OH occurrence by 4.08 times (C.I for exp(B): 1.20\u201313.77) compared to the group that did not take drugs. It was shown that the risk of recurrence of BPPV was significantly reduced in the no recurrence group compared to the multiple recurrence group when there was no OH (p\u2009=\u20090.000; aOR 0.0000002). Also, the risk of recurrence was significantly reduced in the no recurrence group compared to the multiple recurrence group when there was no drug-taking (p\u2009=\u20090.000 aOR 0.0000001). This study is the first study that studied the effect of OH on the recurrence of BPPV and showed the possibility that OH could partially influence the recurrence of BPPV.<\/jats:p>","DOI":"10.1038\/s41598-022-15029-5","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T15:04:16Z","timestamp":1655996656000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Relationship between orthostatic hypotension and recurrence of benign paroxysmal positional vertigo"],"prefix":"10.1038","volume":"12","author":[{"given":"Moon Jung","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6182-9184","authenticated-orcid":false,"given":"Gu il","family":"Rhim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"15029_CR1","doi-asserted-by":"publisher","first-page":"273","DOI":"10.21053\/ceo.2018.00381","volume":"12","author":"GI Rhim","year":"2019","unstructured":"Rhim, G. I. Serum vitamin D and long-term outcomes of benign paroxysmal positional vertigo. Clin. Exp. Otorhinolaryngol. 12, 273\u2013278 (2019).","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"15029_CR2","doi-asserted-by":"publisher","first-page":"159","DOI":"10.4196\/kjpp.2015.19.2.159","volume":"19","author":"Y Lan","year":"2015","unstructured":"Lan, Y. et al. Analysis of the baroreceptor and vestibular receptor inputs in the rostral ventrolateral medulla following hypotension in conscious rats. Korean J. Physiol. Pharmacol. 19, 159\u2013165 (2015).","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"15029_CR3","doi-asserted-by":"publisher","first-page":"363","DOI":"10.4196\/kjpp.2018.22.4.363","volume":"22","author":"GS Jin","year":"2018","unstructured":"Jin, G. S., Li, X. L., Jin, Y. Z., Kim, M. S. & Park, M. R. Role of peripheral vestibular receptors in the control of blood pressure following hypotension. Korean J. Physiol. Pharmacol. 22, 363\u2013368 (2018).","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"15029_CR4","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3233\/VES-190655","volume":"29","author":"HA Kim","year":"2019","unstructured":"Kim, H. A. et al. Hemodynamic orthostatic dizziness\/vertigo: Diagnostic criteria, consensus document of the committee for the classification of vestibular disorders of the B\u00e1r\u00e1ny society. J. Vest Res. 29, 45\u201356 (2019).","journal-title":"J. Vest Res."},{"key":"15029_CR5","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1212\/WNL.46.5.1470","volume":"46","author":"The Consensus Committee of the American Autonomic Society and the American Academy of Neurology","year":"1996","unstructured":"The Consensus Committee of the American Autonomic Society and the American Academy of Neurology. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. Neurology 46, 1470 (1996).","journal-title":"Neurology"},{"key":"15029_CR6","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jns.2015.07.002","volume":"357","author":"JH Choi","year":"2015","unstructured":"Choi, J. H. et al. Audiovestibular impairments associated with intracranial hypotension. J. Neurol. Sci. 357, 96\u2013100 (2015).","journal-title":"J. Neurol. Sci."},{"key":"15029_CR7","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1080\/01616412.2018.1495883","volume":"40","author":"P Xia","year":"2018","unstructured":"Xia, P., Zhang, S. R., Zhou, Z. J., Shao, Y. Q. & Hu, X. Y. Benign paroxysmal positional vertigo in spontaneous intracranial hypotension. Neurol. Res. 40, 868\u2013873 (2018).","journal-title":"Neurol. Res."},{"key":"15029_CR8","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.clinph.2013.08.008","volume":"125","author":"HA Kim","year":"2014","unstructured":"Kim, H. A. & Lee, H. Autonomic dysfunction as a possible cause of residual dizziness after successful treatment in benign paroxysmal positional vertigo. Clin. Neurophysiol. 125, 608\u2013614 (2014).","journal-title":"Clin. Neurophysiol."},{"key":"15029_CR9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s10286-009-0032-3","volume":"20","author":"M Pezzoli","year":"2010","unstructured":"Pezzoli, M. et al. Benign paroxysmal positional vertigo and orthostatic hypotension. Clin. Auton. Res. 20, 27\u201331 (2010).","journal-title":"Clin. Auton. Res."},{"key":"15029_CR10","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1291\/hypres.31.897","volume":"31","author":"JS Wu","year":"2008","unstructured":"Wu, J. S., Yang, Y. C., Lu, F. H., Wu, C. H. & Chang, C. J. Population based study on the prevalence and correlates of orthostatic hypotension\/hypertension and orthostatic dizziness. Hypertens. Res. 31, 897\u2013904 (2008).","journal-title":"Hypertens. Res."},{"key":"15029_CR11","first-page":"471","volume":"34","author":"EJ Jeon","year":"2013","unstructured":"Jeon, E. J. et al. Clinical significance of orthostatic dizziness in the diagnosis of benign paroxysmal positional vertigo and orthostatic intolerance. Am. J. Otolaryngol. Head Neck Med. Surg. 34, 471\u2013476 (2013).","journal-title":"Am. J. Otolaryngol. Head Neck Med. Surg."},{"key":"15029_CR12","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1161\/01.HYP.19.6.508","volume":"19","author":"GH Rutan","year":"1992","unstructured":"Rutan, G. H. et al. Orthostatic hypotension in older adults\u2014The cardiovascular health study. Hypertension 19, 508\u2013519 (1992).","journal-title":"Hypertension"},{"key":"15029_CR13","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.autneu.2009.03.007","volume":"148","author":"K Tanaka","year":"2009","unstructured":"Tanaka, K., Abe, C., Awazu, C. & Morita, H. Vestibular system plays a significant role in arterial pressure control during head-up tilt in young subjects. Auton. Neurosci. 148, 90\u201396 (2009).","journal-title":"Auton. Neurosci."},{"key":"15029_CR14","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00221-011-2989-0","volume":"217","author":"M Aoki","year":"2012","unstructured":"Aoki, M., Sakaida, Y., Tanaka, K., Mizuta, T. & Ito, M. Evidence for vestibular dysfunction in orthostatic hypotension. Exp. Brain. Res. 217, 251\u2013259 (2012).","journal-title":"Exp. Brain. Res."},{"key":"15029_CR15","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1136\/jnnp.2006.100420","volume":"78","author":"M von Brevern","year":"2007","unstructured":"von Brevern, M. et al. Epidemiology of benign paroxysmal positional vertigo: A population based study. J. Neurol. Neurosurg. Psychiatry. 78, 710\u2013715 (2007).","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"key":"15029_CR16","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1097\/00005537-200004000-00022","volume":"110","author":"EM Gross","year":"2000","unstructured":"Gross, E. M., Ress, B. D., Viirre, E. S., Nelson, J. R. & Harris, J. P. Intractable benign paroxysmal positional vertigo in patients with Meniere\u2019s disease. Laryngoscope. 110, 655\u2013659 (2000).","journal-title":"Laryngoscope."},{"key":"15029_CR17","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1097\/SCS.0b013e3181c50e11","volume":"21","author":"H Isildak","year":"2010","unstructured":"Isildak, H., Albayram, S. & Isildak, H. Spontaneous intracranial hypotension syndrome accompanied by bilateral hearing loss and venous engorgement in the internal acoustic canal and positional change of audiography. J. Craniofac. Surg. 21, 165\u2013167 (2010).","journal-title":"J. Craniofac. Surg."},{"key":"15029_CR18","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1080\/00016489.2016.1247985","volume":"137","author":"J Tan","year":"2017","unstructured":"Tan, J., Deng, Y., Zhang, T. & Wang, M. Clinical characteristics and treatment outcomes for benign paroxysmal positional vertigo comorbid with hypertension. Acta Otolaryngol. 137, 482\u2013484 (2017).","journal-title":"Acta Otolaryngol."},{"key":"15029_CR19","doi-asserted-by":"publisher","first-page":"207","DOI":"10.2147\/CIA.S129868","volume":"12","author":"EA Aydin","year":"2017","unstructured":"Aydin, E. A., Isik, T. A. & Soysal, P. Which is preferable for orthostatic hypotension diagnosis in older adults: Active standing test or head-up tilt table test?. Clin. Interv. Aging. 12, 207\u2013212 (2017).","journal-title":"Clin. Interv. Aging."},{"key":"15029_CR20","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1152\/ajpregu.00298.2002","volume":"283","author":"KD Monahan","year":"2002","unstructured":"Monahan, K. D. & Ray, C. A. Vestibulosympathetic reflex during orthostatic challenge in aging humans. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283, 1027\u20131032 (2002).","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-15029-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-15029-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-15029-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T06:12:36Z","timestamp":1669356756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-15029-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,23]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["15029"],"URL":"https:\/\/doi.org\/10.1038\/s41598-022-15029-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,23]]},"assertion":[{"value":"13 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10685"}}