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Previously, we reported that SLC26A7 is also involved in iodide transport and that <jats:italic>Slc26a7<\/jats:italic> is a novel causative gene for congenital hypothyroidism. However, its detailed role in vivo remains to be elucidated. We generated mice that were deficient in <jats:italic>Slc26a7<\/jats:italic> and <jats:italic>Slc26a4<\/jats:italic> to delineate differences and associations in their roles in iodide transport. <jats:italic>Slc26a7<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice showed goitrous congenital hypothyroidism and mild growth failure on a normal diet. <jats:italic>Slc26a7<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice with a low iodine environment showed marked growth failure. In contrast, <jats:italic>Slc26a4<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice showed no growth failure and hypothyroidism in the same low iodine environment. Double-deficient mice showed more severe growth failure than <jats:italic>Slc26a7<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice. RNA-seq analysis revealed that the number of differentially expressed genes (DEGs) in <jats:italic>Slc26a7<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice was significantly higher than that in <jats:italic>Slc26a4<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice. These indicate that SLC26A7 is more strongly involved in iodide transport and the maintenance of thyroid function than SLC26A4.<\/jats:p>","DOI":"10.1038\/s41598-022-15151-4","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T14:04:59Z","timestamp":1656943499000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The iodide transporter Slc26a7 impacts thyroid function more strongly than Slc26a4 in mice"],"prefix":"10.1038","volume":"12","author":[{"given":"Naoya","family":"Yamaguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsushi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoo","family":"Ogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izuki","family":"Amano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Kameo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Koibuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Ugawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruo","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"15151_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clp.2017.10.004","volume":"45","author":"AJ Wassner","year":"2018","unstructured":"Wassner, A. 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