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This was a cross-sectional observational study of individuals with inflammatory bowel disease (IBD) recruited from a Gastroenterology clinic who underwent non-mydriatic retinal photography. Deidentified images were examined for drusen, and drusen counts and size were compared with matched controls, and examined for clinical associations. The cohort with IBD\u00a0comprised 19 individuals with ulcerative colitis, 41 with Crohn\u2019s disease and three with indeterminate colitis, including 34 males (54%)  and\u00a0an overall median age of 48\u00a0(IQR 23)\u00a0years. Their median IBD duration was 7\u00a0(IQR 10)\u00a0years, median CRP level was 7 (IQR 14)\u00a0mg\/L, and 28 (44%) had complications (fistula, stricture, bowel resection etc.), while 28 with Crohn\u2019s disease (68%) had colonic involvement. Drusen counts were higher in IBD than controls (12\u2009\u00b1\u200934, 3\u2009\u00b1\u20098 respectively, <jats:italic>p\u2009=<\/jats:italic>\u20090.04). Counts\u2009\u2265\u200910 were also more common (14, 22%, and 4, 6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02, OR 4.21, 95%CI 1.30 to 13.63), and associated with longer disease duration (<jats:italic>p<\/jats:italic>\u2009=\u20090.01, OR 1.06, 95%CI 1.00 to 1.13), an increased likelihood of complications (<jats:italic>p<\/jats:italic>\u2009=\u20090.003, OR 6.90, 95%CI 1.69 to 28.15) and higher CRP levels at recruitment (<jats:italic>p<\/jats:italic>\u2009=\u20090.008, OR1.02, 95%CI 1.00 to 1.05). Increased retinal drusen were found in all four individuals with Crohn\u2019s disease and IgA glomerulonephritis. IBD and drusen may share pathogenetic mechanisms and underlying risk factors such as complement activation.<\/jats:p>","DOI":"10.1038\/s41598-022-15232-4","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T13:03:14Z","timestamp":1657544594000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Retinal drusen counts are increased in inflammatory bowel disease, and with longer disease duration, more complications and associated IgA glomerulonephritis"],"prefix":"10.1038","volume":"12","author":[{"given":"E.","family":"Nicklason","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Glance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Abel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Harraka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Colville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Savige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"issue":"21","key":"15232_CR1","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1056\/NEJMra0804647","volume":"361","author":"C Abraham","year":"2009","unstructured":"Abraham, C. & Cho, J. 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