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Under exogenous Cd stress, field experiments were conducted to understand the effects of lime (0, 750, 2250 and 3750\u00a0kg\u00a0hm<jats:sup>\u22122<\/jats:sup>) applied and oxalic acid (0, 0.1 and 0.2\u00a0mol\u00a0L<jats:sup>\u22121<\/jats:sup>) leaves sprayed on Cd accumulation, antioxidant system and medicinal components of <jats:italic>P. notoginseng<\/jats:italic>. The results showed that Lime and foliar spray of oxalic acid were able to elevate Ca<jats:sup>2+<\/jats:sup> and alleviate Cd<jats:sup>2+<\/jats:sup> toxicity in <jats:italic>P. notoginseng<\/jats:italic> under Cd stress. The addition of lime and oxalic acid increased the activities of antioxidant enzymes and alters osmoregulator metabolism. The most significant increase in CAT activities increased by 2.77 folds. And the highest increase of SOD activities was 1.78 folds under the application of oxalic acid. While MDA content decreased by 58.38%. There were very significant correlation with soluble sugar, free amino acid, proline and soluble protein. Lime and oxalic acid were able to increase calcium ions (Ca<jats:sup>2+<\/jats:sup>), decrease Cd content and improve the stress resistance of <jats:italic>P. notoginseng<\/jats:italic>, while increasing the production of total saponins and flavonoids. Cd content were the lowest, 68.57% lower than controls, and met the standard value (Cd\u2009\u2264\u20090.5\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>, GB\/T 19086-2008). The proportion of SPN was 7.73%, which reached the highest level of all treatments, the flavonoids content increased significantly by 21.74%, which reached the medicinal standard value and optimal yield.<\/jats:p>","DOI":"10.1038\/s41598-022-15280-w","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T09:03:33Z","timestamp":1657098213000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of lime and oxalic acid on antioxidant enzymes and active components of Panax notoginseng under cadmium stress"],"prefix":"10.1038","volume":"12","author":[{"given":"Qi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqun","family":"Zu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"issue":"2","key":"15280_CR1","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1007\/s11356-016-7972-7","volume":"24","author":"Y Lu","year":"2017","unstructured":"Lu, Y. et al. 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