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The study was aimed to evaluate the relationship between cough during TT and pleural pressure (Ppl) changes (\u2206P). Instantaneous Ppl was measured after withdrawal of predetermined volumes of pleural fluid. Fluid withdrawal (FW) and Ppl measurement (PplM) periods were analyzed separately using the two sample Kolmogorov\u2013Smirnov test and the nonparametric skew to assess differences between \u2206P distributions in periods with and without cough. The study involved 59 patients, median age 66\u00a0years, median withdrawn fluid volume 1800\u00a0mL (1330\u2009\u00f7\u20092400\u00a0mL). In total, 1265 cough episodes were recorded in 52 patients, in 24% of FW and 19% of PplM periods, respectively. Cough was associated with significant changes in \u2206P distribution (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), decreasing the left tail of \u2206P distribution for FW periods (the skew\u2009=\u2009\u2009\u2212\u20090.033\u00a0vs.\u2009\u2212\u20090.182) and increasing the right tail for PplM periods (the skew\u2009=\u20090.182 vs. 0.088). Although cough was more frequent in 46 patients with normal pleural elastance (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), it was associated with significantly higher \u2206P in patients with elevated elastance (median Ppl increase 2.9 vs. 0.2\u00a0cmH<jats:sub>2<\/jats:sub>O, respectively). Cough during TT is associated with small but beneficial trend in Ppl changes, particularly in patients with elevated pleural elastance, and should not be considered solely as an adverse event.<\/jats:p>","DOI":"10.1038\/s41598-022-15480-4","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T12:03:34Z","timestamp":1657195414000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of spontaneous cough on pleural pressure changes during therapeutic thoracentesis"],"prefix":"10.1038","volume":"12","author":[{"given":"Anna M.","family":"Stecka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta M.","family":"Grabczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Michnikowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Zieli\u0144ska-Krawczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafa\u0142","family":"Krenke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"G\u00f3lczewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"issue":"8","key":"15480_CR1","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1056\/NEJMra1403503","volume":"378","author":"D Feller-Kopman","year":"2018","unstructured":"Feller-Kopman, D. & Light, R. 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