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Here, we exploited FR235222 to ask if changes in histone acetylation regulate developmental stage transition of\n                    <jats:italic>Theileria annulata,<\/jats:italic>\n                    another apicomplexan species. We found that FR235222 treatment of\n                    <jats:italic>T. annulata<\/jats:italic>\n                    -infected transformed leukocytes induced a proliferation arrest. The blockade in proliferation was due to drug-induced conversion of intracellular schizonts to merozoites that lack the ability to maintain host leukocyte cell division. Induction of merogony by FR235222 leads to an increase in expression of merozoite-marker (rhoptry) proteins. RNA-seq of FR235222-treated\n                    <jats:italic>T. annulata<\/jats:italic>\n                    -infected B cells identified deregulated expression of 468 parasite genes including a number encoding parasite ApiAP2 transcription factors. Thus, similar to\n                    <jats:italic>T. gondii<\/jats:italic>\n                    , FR235222 inhibits\n                    <jats:italic>T. annulata<\/jats:italic>\n                    HDAC (TaHDAC1) activity and places parasite histone acetylation as a major regulatory event of the transition from schizonts to merozoites.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-15518-7","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T08:10:55Z","timestamp":1658823055000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Theileria annulata histone deacetylase 1 (TaHDAC1) initiates schizont to merozoite stage conversion"],"prefix":"10.1038","volume":"12","author":[{"given":"Shahin","family":"Tajeri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Momeux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Saintpierre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Mfarrej","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Chapple","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Mourier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Shiels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Ariey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnab","family":"Pain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Langsley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"15518_CR1","doi-asserted-by":"publisher","first-page":"599","DOI":"10.20506\/rst.34.2.2383","volume":"34","author":"WI Morrison","year":"2015","unstructured":"Morrison, W. 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