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If inoperable, long-term benzimidazole therapy is required, which is associated with high healthcare costs and occasionally with increased morbidity. The aim of our study was to determine the role <jats:sup>18<\/jats:sup>F-fluorodeoxyglucose (FDG) positron emission tomography\/computed tomography (PET\/CT) in staging of patients with alveolar echinococcosis and to identify quantitative imaging parameters related to patient outcome and\/or duration of\u00a0benzimidazole therapy. In this single-center retrospective cohort study, 47 PET\/CT performed for staging in patients with confirmed alveolar echinococcosis were analysed. In 43 patients (91%) benzimidazole therapy was initiated and was successfully stopped after a median of 870\u00a0days (766\u20132517) in 14\/43 patients (33%). In inoperable patients, tests for trend of survivor functions displayed clear trends for longer benzimidazole therapy duration (p\u2009=\u20090.05; n\u2009=\u200925), and for longer\u00a0time intervals to reach non-detectable serum concentration of Em-18 antibodies (p\u2009=\u20090.01, n\u2009=\u200915) across tertiles of SUVratio (maximum standardized uptake value in the echinococcus manifestation compared to normal liver tissue). Hence, in inoperable patients with alveolar echinococcosis, PET\/CT performed for staging may predict the duration of benzimidazole therapy.<\/jats:p>","DOI":"10.1038\/s41598-022-15641-5","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T10:02:58Z","timestamp":1657101778000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Prediction of benzimidazole therapy duration with PET\/CT in inoperable patients with alveolar echinococcosis"],"prefix":"10.1038","volume":"12","author":[{"given":"Lars","family":"Husmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannes","family":"Gruenig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caecilia S.","family":"Reiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansgar","family":"Deibel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Ledergerber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Liberini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Skawran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs J.","family":"Muehlematter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Messerli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Hasse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat","family":"Muellhaupt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin W.","family":"Huellner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"15641_CR1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1128\/CMR.17.1.107-135.2004","volume":"17","author":"J Eckert","year":"2004","unstructured":"Eckert, J. & Deplazes, P. 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