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We retrospectively analyzed the U.S. National Health and Nutrition Examination Survey 2003\u20132004 and compared the baseline demographics in individuals according to the presence of NAFLD (fatty liver index [FLI]\u2009\u2265\u200960). Logistic regression analysis was performed to determine whether OCP concentration affected NAFLD prevalence and subgroup analyses regarding NAFLD-related variables and advanced hepatic fibrosis (FIB-4\u2009\u2265\u20092.67) were performed. Of the 1515 individuals, 579 (38.2%) had NAFLD. Oxychlordane showed concentration-dependent risk for NAFLD (OR 3.471 in fourth quartile [Q4]; 95% CI 1.865\u20136.458;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.007).\n                    <jats:italic>p,p\u2032<\/jats:italic>\n                    -DDE and trans-nonachlor showed similar trends without statistical significance. Conversely, mirex showed the lowest risk for NAFLD in the highest concentration quartile (OR 0.29 in Q4; 95% CI 0.175\u20130.483;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). Oxychlordane showed the most pronounced association with the levels of each component of FLI and liver enzymes. None of the OCPs were significantly associated with advanced fibrosis. In conclusion, among OCPs, exposure to oxychlordane showed the most prominent impact associated with NAFLD.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-15741-2","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T06:02:33Z","timestamp":1657260153000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Association between organochlorine pesticides and nonalcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003\u20132004"],"prefix":"10.1038","volume":"12","author":[{"given":"Hyunji","family":"Sang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Na","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hee","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungdo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hee","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"15741_CR1","unstructured":"CDC. 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