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(event-based analysis) This study included 75 POAG eyes [visual field (VF) mean deviation\u2009&lt;\u2009\u2212\u200910 decibels, mean follow-up; 2.3\u00a0years] and 33 healthy eyes. Of 75 POAG eyes, 17 (22.7\u00a0%) and 58 eyes (77.3\u00a0%) were classified into the VF progression and stable groups, respectively. The VF progression group showed significantly faster VD loss than the stable group. (cpVD; \u2212\u20091.76 vs. \u2212\u20090.84\u00a0%\/year, mVD; \u2212\u20091.10 vs. \u2212\u20090.47\u00a0%\/year, P\u2009&lt;\u20090.05) However, the rates of change in circumpapillary retinal nerve fiber layer and macular ganglion cell complex thickness were similar between the groups. (cpRNFLT; \u2212\u20090.67 vs. \u2212\u20090.53\u00a0<jats:inline-formula><jats:alternatives><jats:tex-math>$$\\mu$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mi>\u03bc<\/mml:mi>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula>m\/year, GCCT; \u2212\u20090.48 vs. \u2212\u20090.12\u00a0<jats:inline-formula><jats:alternatives><jats:tex-math>$$\\mu$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mi>\u03bc<\/mml:mi>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula>m\/year, P\u2009&gt;\u20090.05) Event-based analysis showed stronger agreement between VD and VF progression (cpVD; kappa value (k)\u2009=\u20090.630, mVD; k\u2009=\u20090.667, P\u2009&lt;\u20090.05) than that between structure and VF progression. (cpRNFLT; k\u2009=\u20090.111, GCCT; k\u2009=\u20090.194, P\u2009&gt;\u20090.05). In conclusion, VD loss showed better progression detection capabilities than structural loss in advanced POAG eyes. Detection of cpVD and mVD loss may be useful for detecting progression in the advanced stages of POAG to complement other reference standard strategies.<\/jats:p>","DOI":"10.1038\/s41598-022-16083-9","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T12:04:27Z","timestamp":1657886667000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Progression detection capabilities of circumpapillary and macular vessel density in advanced glaucomatous eyes"],"prefix":"10.1038","volume":"12","author":[{"given":"Anna","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Rim","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong Won","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"16083_CR1","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","volume":"363","author":"RN Weinreb","year":"2004","unstructured":"Weinreb, R. 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