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Because individuals with this response are unable to metabolize the toxic acetaldehyde derived from alcohol effectively, the response offers a potential indicator of the health risks associated with alcohol intake. Depression is a major health problem linked to alcohol consumption; it might also be associated with the alcohol flushing response. Therefore, we examined the association between the alcohol flushing response and the risk of depression in the general population of South Korea. Our analysis included 139,380 participants and used data from the 2019 Korean Community Health Survey. Only current drinkers were considered in the analysis. The relationship between the alcohol flushing response and depression was evaluated by logistic regression analysis using SAS 9.4. Of the participants, more than one-third were current flushers; compared to never flushers, current flushers had a significantly greater risk of depression (adjusted odds ratio [AOR] 1.23, 95% confidence interval [CI] 1.12\u20131.34, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Former flushers did not exhibit a risk of depression. The risk of depression was significantly greater among alcohol flushers who drank\u2009&lt;\u200915\u00a0g alcohol\/day (&lt;\u20095\u00a0g alcohol\/day: AOR 1.20, 95% CI 1.07\u20131.35, <jats:italic>P<\/jats:italic>\u2009=\u20090.002; 5\u201314.9\u00a0g alcohol\/day: AOR 1.39, 95% CI 1.13\u20131.70, <jats:italic>P<\/jats:italic>\u2009=\u20090.002). In conclusion, a large number of South Koreans experience the alcohol flushing response; compared with never flushers, current flushers are more likely to develop depression with a small dose of alcohol (&lt;\u200915\u00a0g alcohol\/day).<\/jats:p>","DOI":"10.1038\/s41598-022-16276-2","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T14:03:33Z","timestamp":1658498613000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The alcohol flushing response is associated with the risk of depression"],"prefix":"10.1038","volume":"12","author":[{"given":"Seonghee","family":"Jeon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heewon","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inhyung","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-il","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"16276_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000050","volume":"6","author":"PJ Brooks","year":"2009","unstructured":"Brooks, P. 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