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During the resuscitation period, changes in cerebral hemoglobin oxygen saturation (ScO<jats:sub>2<\/jats:sub>) have been identified by near-infrared spectroscopy (NIRS). However, in asphyxiated neonates, the relationship between these changes and brain injury is not known. Three-wavelength near-infrared time-resolved spectroscopy, an advanced technology for NIRS, allows for the estimation of ScO<jats:sub>2<\/jats:sub> and cerebral blood volume (CBV). Here, we studied changes in ScO<jats:sub>2<\/jats:sub> and CBV during the resuscitation period after hypoxic-ischemic insult and the relationship between these changes after insult and histopathological brain injuries on day 5 after insult using an asphyxiated piglet model. Of 36 newborn piglets subjected to hypoxic-ischemic insult, 29 were analyzed. ScO<jats:sub>2<\/jats:sub> and CBV were measured 0, 5, 10, 15, and 30\u00a0min after the insult. Brain tissue was histologically evaluated on day 5. ScO<jats:sub>2<\/jats:sub> and CBV increased immediately after the insult, reached a peak, and then maintained a consistent value. The increase in CBV 5 to 30\u00a0min after the insult was significantly correlated with histopathological injury scores. However, there was no correlation with ScO<jats:sub>2<\/jats:sub>. In conclusion, an increase in CBV within 30\u00a0min after hypoxic-ischemic insult reflects the histopathological brain injury on day 5 after insult in a piglet model.<\/jats:p>","DOI":"10.1038\/s41598-022-16625-1","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T10:04:30Z","timestamp":1659348270000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cerebral hemodynamic response during the resuscitation period after hypoxic-ischemic insult predicts brain injury on day 5 after insult in newborn piglets"],"prefix":"10.1038","volume":"12","author":[{"given":"Yasuhiro","family":"Nakao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinmon","family":"Htun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Mitsuie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Koyano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiko","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Miki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kusaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"issue":"Suppl 1","key":"16625_CR1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/pr.2013.206","volume":"74","author":"AC Lee","year":"2013","unstructured":"Lee, A. 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