{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:12:22Z","timestamp":1791547942071,"version":"4.3.4"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate the relationship between non-cystic thickening of the macula on optical coherence tomography (OCT) and retinal vascular leakage on fluorescein angiogram (FA) in patients with uveitis. A cross-sectional study of patients seen in the uveitis clinic. Patients with any degree of inflammatory cells in the anterior vitreous were included, provided that no macular cyst or subretinal fluid or macular atrophy was observed in OCT. The correlation between OCT features and best corrected visual acuity (BCVA), the degree of inflammation, and FA findings were examined. The severity of vascular leakage in FA was graded for optic nerve, macula and posterior and peripheral leakage. We used generalized estimation equation to assess the associations between macular thickness and volume with angiographic scores. A total of 43 patients (100 exam data) met inclusion criteria. There was a significant relationship between OCT parameters (central macular thickness, 3\u00a0mm and 6\u00a0mm perifoveal macular thickness as well as total and central macular volume) with angiographic scores (macular, optic disc, posterior and peripheral vascular leakage score) (all P values &lt;\u20090.0001). The correlation between the 6\u00a0mm perifoveal thickness and peripheral vascular leakage score (R\u2009=\u20090.76; P\u2009&lt;\u20090.001) was stronger than the correlation of CMT with this angiographic score (R\u2009=\u20090.69; P\u2009&lt;\u20090.001). Non-cystic thickening of the macula on OCT, especially in perifoveal area, is a reliable predictor of the presence of retinal vascular leakage in patients with uveitis.<\/jats:p>","DOI":"10.1038\/s41598-022-17701-2","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T12:19:48Z","timestamp":1659701988000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Non-cystic macular thickening on optical coherence tomography as an alternative to fluorescein angiography for predicting retinal vascular leakage in early stages of uveitis"],"prefix":"10.1038","volume":"12","author":[{"given":"Nazanin","family":"Ebrahimiadib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Kianzad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Zarei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaneh","family":"Davoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Riazi-Esfahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Bazvand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Mahdizad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobeck S.","family":"Modjtahedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"17701_CR1","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1136\/bjo.2003.037226","volume":"88","author":"OM Durrani","year":"2004","unstructured":"Durrani, O. M. et al. Degree, duration, and causes of visual loss in uveitis. Br. J. Ophthalmol. 88, 1159\u20131162 (2004).","journal-title":"Br. J. Ophthalmol."},{"key":"17701_CR2","doi-asserted-by":"crossref","unstructured":"Castellano, C. G., Stinnett, S. S., Mettu, P. S., McCallum, R. M. & Jaffe, G. J. Retinal thickening in iridocyclitis. Am. J. Ophthalmol. 148, (2009).","DOI":"10.1016\/j.ajo.2009.03.034"},{"key":"17701_CR3","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1136\/bjophthalmol-2016-309837","volume":"102","author":"JE Knickelbein","year":"2018","unstructured":"Knickelbein, J. E., Tucker, W., Kodati, S., Akanda, M. & Sen, H. N. Non-invasive method of monitoring retinal vasculitis in patients with birdshot chorioretinopathy using optical coherence tomography. Br. J. Ophthalmol. 102, 815\u2013820 (2018).","journal-title":"Br. J. Ophthalmol."},{"key":"17701_CR4","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1097\/IAE.0000000000002038","volume":"39","author":"AS Thomas","year":"2019","unstructured":"Thomas, A. S., Hatef, A. L., Stinnett, S. S., Keenan, R. T. & Jaffe, G. J. Perivascular thickening on optical coherence tomography as a marker of inflammation in birdshot retinochoroiditis. Retina 39, 956\u2013963 (2019).","journal-title":"Retina"},{"key":"17701_CR5","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.jcjo.2013.05.009","volume":"48","author":"BK Hong","year":"2013","unstructured":"Hong, B. K., Khanamiri, H. N. & Rao, N. A. Role of ultra-widefield fluorescein angiography in the management of uveitis. Can. J. Ophthalmol. 48, 489\u2013493 (2013).","journal-title":"Can. J. Ophthalmol."},{"key":"17701_CR6","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1097\/BOR.0000000000000271","volume":"28","author":"JT Rosenbaum","year":"2016","unstructured":"Rosenbaum, J. T., Sibley, C. H. & Lin, P. Retinal vasculitis. Curr. Opin. Rheumatol. 28, 228\u2013235 (2016).","journal-title":"Curr. Opin. Rheumatol."},{"key":"17701_CR7","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.ajo.2005.03.057","volume":"140","author":"DA Jabs","year":"2005","unstructured":"Jabs, D. A. et al. Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am. J. Ophthalmol. 140, 509\u2013516 (2005).","journal-title":"Am. J. Ophthalmol."},{"key":"17701_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1869-5760-3-30","volume":"3","author":"HA Leder","year":"2013","unstructured":"Leder, H. A. et al. Ultra-wide-field retinal imaging in the management of non-infectious retinal vasculitis. J. Ophthalmic Inflam. Infect. 3, 1\u20136 (2013).","journal-title":"J. Ophthalmic Inflam. Infect."},{"key":"17701_CR9","unstructured":"American Academy of Ophthalmology. BCSC 2020\u20132021 series: Section 9\u2014Uveitis and Ocular Inflammation. in (ed. Sen, H. N.) (2021)."},{"key":"17701_CR10","doi-asserted-by":"publisher","first-page":"20037","DOI":"10.1038\/s41598-021-99485-5","volume":"11","author":"M Zarei","year":"2021","unstructured":"Zarei, M., Pesarakli, H., Yaseri, M., Etesali, H. & Ebrahimiadib, N. Peripapillary optical coherence tomography as an alternative to fluorescein angiography for monitoring Behcet\u2019s retinal vasculitis. Sci. Rep. 11, 20037 (2021).","journal-title":"Sci. Rep."},{"key":"17701_CR11","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3200\/JEXE.71.1.53-70","volume":"73","author":"NC Silver","year":"2004","unstructured":"Silver, N. C., Hittner, J. B. & May, K. Testing dependent correlations with nonoverlapping variables: A monte carlo simulation. J. Exp. Educ. 73, 53\u201369 (2004).","journal-title":"J. Exp. 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Ophthalmol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-17701-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-17701-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-17701-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T05:28:46Z","timestamp":1669354126000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-17701-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,5]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["17701"],"URL":"https:\/\/doi.org\/10.1038\/s41598-022-17701-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,5]]},"assertion":[{"value":"18 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests. BM received research grant support from Genentech and VoxelCloud (not a conflict).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"13473"}}