{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:07:12Z","timestamp":1790687232966,"version":"4.1.0"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K12613"],"award-info":[{"award-number":["21K12613"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>According to the theory of embodied cognition, semantic processing is closely coupled with body movements. For example, constraining hand movements inhibits memory for objects that can be manipulated with the hands. However, it has not been confirmed whether body constraint reduces brain activity related to semantics. We measured the effect of hand constraint on semantic processing in the parietal lobe using functional near-infrared spectroscopy. A pair of words representing the names of hand-manipulable (e.g., cup or pencil) or nonmanipulable (e.g., windmill or fountain) objects were presented, and participants were asked to identify which object was larger. The reaction time (RT) in the judgment task and the activation of the left intraparietal sulcus (LIPS) and left inferior parietal lobule (LIPL), including the supramarginal gyrus and angular gyrus, were analyzed. We found that constraint of hand movement suppressed brain activity in the LIPS toward hand-manipulable objects and affected RT in the size judgment task. These results indicate that body constraint reduces the activity of brain regions involved in semantics. Hand constraint might inhibit motor simulation, which, in turn, would inhibit body-related semantic processing.<\/jats:p>","DOI":"10.1038\/s41598-022-17702-1","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T17:03:29Z","timestamp":1659978209000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hand constraint reduces brain activity and affects the speed of verbal responses on semantic tasks"],"prefix":"10.1038","volume":"12","author":[{"given":"Sae","family":"Onishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihito","family":"Tobita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Makioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"17702_CR1","unstructured":"Lakoff, G., & Johnson, M. Philosophy in the Flesh (The Embodied Mind and Its Challenge to Western Thought) (Basic Books, 1999)."},{"key":"17702_CR2","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1080\/02643290442000310","volume":"22","author":"V Gallese","year":"2005","unstructured":"Gallese, V. & Lakoff, G. The brain\u2019s concepts: The role of the sensory-motor system in conceptual knowledge. Cogn. Neuropsychol. 22, 455\u2013479 (2005).","journal-title":"Cogn. Neuropsychol."},{"key":"17702_CR3","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1146\/annurev.psych.59.103006.093639","volume":"59","author":"LW Barsalou","year":"2008","unstructured":"Barsalou, L. W. Grounded cognition. Annu. Rev. Psychol. 59, 617\u2013645 (2008).","journal-title":"Annu. Rev. Psychol."},{"key":"17702_CR4","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1080\/17470910701563608","volume":"3","author":"V Gallese","year":"2008","unstructured":"Gallese, V. Mirror neurons and the social nature of language: The neural exploitation hypothesis. Soc. Neurosci. 3, 317\u2013333 (2008).","journal-title":"Soc. Neurosci."},{"key":"17702_CR5","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.tics.2011.10.001","volume":"15","author":"JR Binder","year":"2011","unstructured":"Binder, J. R. & Desai, R. H. The neurobiology of semantic memory. Trends Cogn. Sci. 15, 527\u2013536 (2011).","journal-title":"Trends Cogn. Sci."},{"key":"17702_CR6","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/dev.21055","volume":"55","author":"ML Anderson","year":"2013","unstructured":"Anderson, M. L. & Penner-Wilger, M. Neural reuse in the evolution and development of the brain: Evidence for developmental homology?. Dev. Psychobiol. 55, 42\u201351 (2013).","journal-title":"Dev. Psychobiol."},{"key":"17702_CR7","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.tics.2014.02.008","volume":"18","author":"RA Zwaan","year":"2014","unstructured":"Zwaan, R. A. Embodiment and language comprehension: Reframing the discussion. Trends Cogn. Sci. 18, 229\u2013234 (2014).","journal-title":"Trends Cogn. Sci."},{"key":"17702_CR8","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.neubiorev.2016.07.033","volume":"69","author":"G Buccino","year":"2016","unstructured":"Buccino, G., Colag\u00e8, I., Gobbi, N. & Bonaccorso, G. Grounding meaning in experience: A broad perspective on embodied language. Neurosci. Biobehav. Rev. 69, 69\u201378 (2016).","journal-title":"Neurosci. Biobehav. Rev."},{"key":"17702_CR9","first-page":"185","volume":"116","author":"M Tucker","year":"2004","unstructured":"Tucker, M. & Ellis, R. Action priming by briefly presented objects. Acta Physiol. (Oxf) 116, 185\u2013203 (2004).","journal-title":"Acta Physiol. (Oxf)"},{"key":"17702_CR10","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cognition.2006.12.010","volume":"106","author":"DN Bub","year":"2008","unstructured":"Bub, D. N., Masson, M. E. J. & Cree, G. S. Evocation of functional and volumetric gestural knowledge by objects and words. Cognition 106, 27\u201358 (2008).","journal-title":"Cognition"},{"key":"17702_CR11","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.brainres.2008.11.064","volume":"1253","author":"AM Borghi","year":"2009","unstructured":"Borghi, A. M. & Riggio, L. Sentence comprehension and simulation of object temporary, canonical and stable affordances. Brain Res. 1253, 117\u2013128 (2009).","journal-title":"Brain Res."},{"key":"17702_CR12","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3389\/fnhum.2015.00351","volume":"9","author":"AM Borghi","year":"2015","unstructured":"Borghi, A. M. & Riggio, L. Stable and variable affordances are both automatic and flexible. Front. Hum. Neurosci. 9, 351 (2015).","journal-title":"Front. Hum. Neurosci."},{"key":"17702_CR13","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jphysparis.2008.03.004","volume":"102","author":"BZ Mahon","year":"2008","unstructured":"Mahon, B. Z. & Caramazza, A. A critical look at the embodied cognition hypothesis and a new proposal for grounding conceptual content. J. Physiol. Paris 102, 59\u201370 (2008).","journal-title":"J. Physiol. Paris"},{"key":"17702_CR14","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1515\/langcog.2010.004","volume":"2","author":"A Chatterjee","year":"2010","unstructured":"Chatterjee, A. Disembodying cognition. Langu. Cognit. 2, 79\u2013116 (2010).","journal-title":"Langu. Cognit."},{"key":"17702_CR15","doi-asserted-by":"publisher","DOI":"10.1007\/s00426-021-01635-x","author":"M Halim Harrak","year":"2022","unstructured":"Halim Harrak, M., Heurley, L. P., Morgado, N., Mennella, R. & Dru, V. The visual size of graspable objects is needed to induce the potentiation of grasping behaviors even with verbal stimuli. Psychol. Res. https:\/\/doi.org\/10.1007\/s00426-021-01635-x (2022).","journal-title":"Psychol. Res."},{"key":"17702_CR16","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1037\/a0026570","volume":"38","author":"E Ambrosini","year":"2012","unstructured":"Ambrosini, E., Sinigaglia, C. & Costantini, M. Tie my hands, Tie my eyes. J. Exp. Psychol. Hum. Percept. Perform. 38, 263\u2013266 (2012).","journal-title":"J. Exp. Psychol. Hum. Percept. Perform."},{"key":"17702_CR17","doi-asserted-by":"publisher","first-page":"e0159108","DOI":"10.1371\/journal.pone.0159108","volume":"11","author":"L Dutriaux","year":"2016","unstructured":"Dutriaux, L. & Gyselinck, V. Learning is better with the hands free: The role of posture in the memory of manipulable objects. PLoS ONE 11, e0159108 (2016).","journal-title":"PLoS ONE"},{"key":"17702_CR18","first-page":"250","volume":"27","author":"S Onishi","year":"2020","unstructured":"Onishi, S. & Makioka, S. How a restraint of hands affects memory of hand manipulable objects: An investigation of hand position and its visibility. Cognit. Stud. 27, 250\u2013261 (2020).","journal-title":"Cognit. Stud."},{"key":"17702_CR19","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1093\/cercor\/bhh080","volume":"14","author":"CD Vargas","year":"2004","unstructured":"Vargas, C. D. et al. The influence of hand posture on corticospinal excitability during motor imagery: A transcranial magnetic stimulation study. Cereb. Cortex 14, 1200\u20131206 (2004).","journal-title":"Cereb. Cortex"},{"key":"17702_CR20","doi-asserted-by":"publisher","first-page":"3423","DOI":"10.1523\/JNEUROSCI.4893-10.2011","volume":"31","author":"L Avanzino","year":"2011","unstructured":"Avanzino, L., Bassolino, M., Pozzo, T. & Bove, M. Use-dependent hemispheric balance. J. Neurosci. 31, 3423\u20133428 (2011).","journal-title":"J. Neurosci."},{"key":"17702_CR21","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1034\/j.1600-0404.2002.1o004.x","volume":"105","author":"S Facchini","year":"2002","unstructured":"Facchini, S., Muellbacher, W., Battaglia, F., Boroojerdi, B. & Hallett, M. Focal enhancement of motor cortex excitability during motor imagery: A transcranial magnetic stimulation study. Acta Neurol. Scand. 105, 146\u2013151 (2002).","journal-title":"Acta Neurol. Scand."},{"key":"17702_CR22","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/1743-0003-11-94","volume":"11","author":"F Kaneko","year":"2014","unstructured":"Kaneko, F., Hayami, T., Aoyama, T. & Kizuka, T. Motor imagery and electrical stimulation reproduce corticospinal excitability at levels similar to voluntary muscle contraction. J. NeuroEng. Rehabil. 11, 94 (2014).","journal-title":"J. NeuroEng. Rehabil."},{"key":"17702_CR23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.neuropsychologia.2017.11.004","volume":"107","author":"D Burin","year":"2017","unstructured":"Burin, D. et al. Movements and body ownership: Evidence from the rubber hand illusion after mechanical limb immobilization. Neuropsychologia 107, 41\u201347 (2017).","journal-title":"Neuropsychologia"},{"key":"17702_CR24","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1093\/cercor\/bhu287","volume":"26","author":"H Burianova","year":"2016","unstructured":"Burianova, H. et al. Adaptive motor imagery: A multimodal study of immobilization-induced brain plasticity. Cereb. Cortex 26, 1072\u20131080 (2016).","journal-title":"Cereb. Cortex"},{"key":"17702_CR25","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/BF00232190","volume":"83","author":"M Taira","year":"1990","unstructured":"Taira, M., Mine, S., Georgopoulos, A. P., Murata, A. & Sakata, H. Parietal cortex neurons of the monkey related to the visual guidance of hand movement. Exp. Brain Res. 83, 29 (1990).","journal-title":"Exp. Brain Res."},{"key":"17702_CR26","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1093\/cercor\/5.5.429","volume":"5","author":"H Sakata","year":"1995","unstructured":"Sakata, H., Taira, M., Murata, A. & Mine, S. Neural mechanisms of visual guidance of hand action in the parietal cortex of the monkey. Cereb. Cortex 5, 429\u2013438 (1995).","journal-title":"Cereb. Cortex"},{"key":"17702_CR27","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1006\/nimg.2000.0635","volume":"12","author":"LL Chao","year":"2000","unstructured":"Chao, L. L. & Martin, A. Representation of manipulable man-made objects in the dorsal stream. Neuroimage 12, 478\u2013484 (2000).","journal-title":"Neuroimage"},{"key":"17702_CR28","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1080\/09658219508253153","volume":"3","author":"G Gainotti","year":"1995","unstructured":"Gainotti, G., Silveri, M. C., Daniel, A. & Giustolisi, L. Neuroanatomical correlates of category-specific semantic disorders: A critical survey. Memory 3, 247\u2013263 (1995).","journal-title":"Memory"},{"key":"17702_CR29","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1093\/brain\/111.5.1173","volume":"111","author":"E de Renzi","year":"1988","unstructured":"de Renzi, E. & Lucchelli, F. Ideational apraxia. Brain 111, 1173\u20131185 (1988).","journal-title":"Brain"},{"key":"17702_CR30","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1002\/ana.410250214","volume":"25","author":"C Ochipa","year":"1989","unstructured":"Ochipa, C., Rothi, L. J. G. & Heilman, K. M. Ideational apraxia: A deficit in tool selection and use. Ann. Neurol. 25, 190\u2013193 (1989).","journal-title":"Ann. Neurol."},{"key":"17702_CR31","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1152\/jn.1997.78.4.2226","volume":"78","author":"A Murata","year":"1997","unstructured":"Murata, A. et al. Object Representation in the Ventral Premotor Cortex (Area F5) of the Monkey. J. Neurophysiol. 78, 2226\u20132230 (1997).","journal-title":"J. Neurophysiol."},{"key":"17702_CR32","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1002\/hbm.20231","volume":"27","author":"T-L Chou","year":"2006","unstructured":"Chou, T.-L. et al. Developmental and skill effects on the neural correlates of semantic processing to visually presented words. Hum. Brain Mapp. 27, 915\u2013924 (2006).","journal-title":"Hum. Brain Mapp."},{"key":"17702_CR33","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/j.neuropsychologia.2006.05.017","volume":"44","author":"A Raposo","year":"2006","unstructured":"Raposo, A., Moss, H. E., Stamatakis, E. A. & Tyler, L. K. Repetition suppression and semantic enhancement: An investigation of the neural correlates of priming. Neuropsychologia 44, 2284\u20132295 (2006).","journal-title":"Neuropsychologia"},{"key":"17702_CR34","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1177\/1073858412440596","volume":"19","author":"ML Seghier","year":"2013","unstructured":"Seghier, M. L. The angular gyrus. Neuroscientist 19, 43\u201361 (2013).","journal-title":"Neuroscientist"},{"key":"17702_CR35","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1093\/cercor\/bhp055","volume":"19","author":"JR Binder","year":"2009","unstructured":"Binder, J. R., Desai, R. H., Graves, W. W. & Conant, L. L. Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studies. Cereb. Cortex 19, 2767\u20132796 (2009).","journal-title":"Cereb. Cortex"},{"key":"17702_CR36","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/S1053-8119(03)00042-9","volume":"18","author":"J Gr\u00e8zes","year":"2003","unstructured":"Gr\u00e8zes, J., Armony, J. L., Rowe, J. & Passingham, R. E. Activations related to \u201cmirror\u201d and \u201ccanonical\u201d neurones in the human brain: An fMRI study. Neuroimage 18, 928\u2013937 (2003).","journal-title":"Neuroimage"},{"key":"17702_CR37","doi-asserted-by":"publisher","first-page":"S110","DOI":"10.1006\/nimg.2001.0841","volume":"14","author":"I Toni","year":"2001","unstructured":"Toni, I., Thoenissen, D. & Zilles, K. Movement preparation and motor intention. Neuroimage 14, S110\u2013S117 (2001).","journal-title":"Neuroimage"},{"key":"17702_CR38","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1093\/brain\/awh522","volume":"128","author":"R Vandenberghe","year":"2005","unstructured":"Vandenberghe, R. et al. Attentional responses to unattended stimuli in human parietal cortex. Brain 128, 2843\u20132857 (2005).","journal-title":"Brain"},{"key":"17702_CR39","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/nature02466","volume":"428","author":"JJ Todd","year":"2004","unstructured":"Todd, J. J. & Marois, R. Capacity limit of visual short-term memory in human posterior parietal cortex. Nature 428, 751\u2013754 (2004).","journal-title":"Nature"},{"key":"17702_CR40","doi-asserted-by":"publisher","first-page":"18906","DOI":"10.1523\/JNEUROSCI.3809-13.2013","volume":"33","author":"BJ Devereux","year":"2013","unstructured":"Devereux, B. J., Clarke, A., Marouchos, A. & Tyler, L. K. Representational similarity analysis reveals commonalities and differences in the semantic processing of words and objects. J. Neurosci. 33, 18906\u201318916 (2013).","journal-title":"J. Neurosci."},{"key":"17702_CR41","doi-asserted-by":"publisher","first-page":"107918","DOI":"10.1016\/j.neuropsychologia.2021.107918","volume":"159","author":"M Lesourd","year":"2021","unstructured":"Lesourd, M. et al. Semantic and action tool knowledge in the brain: Identifying common and distinct networks. Neuropsychologia 159, 107918 (2021).","journal-title":"Neuropsychologia"},{"key":"17702_CR42","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1093\/cercor\/bhn248","volume":"19","author":"B Pelgrims","year":"2009","unstructured":"Pelgrims, B., Andres, M. & Olivier, E. Double dissociation between motor and visual imagery in the posterior parietal cortex. Cereb. Cortex 19, 2298\u20132307 (2009).","journal-title":"Cereb. Cortex"},{"key":"17702_CR43","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S0010-9452(08)70466-0","volume":"43","author":"LJ Buxbaum","year":"2007","unstructured":"Buxbaum, L. J., Kyle, K., Grossman, M. & Coslett, B. Left inferior parietal representations for skilled hand-object interactions: evidence from stroke and corticobasal degeneration. Cortex 43, 411\u2013423 (2007).","journal-title":"Cortex"},{"key":"17702_CR44","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.plrev.2013.11.005","volume":"11","author":"M van Elk","year":"2014","unstructured":"van Elk, M., van Schie, H. & Bekkering, H. Action semantics: A unifying conceptual framework for the selective use of multimodal and modality-specific object knowledge. Phys. Life Rev. 11, 220\u2013250 (2014).","journal-title":"Phys. Life Rev."},{"key":"17702_CR45","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1093\/brain\/123.11.2306","volume":"123","author":"KY Haaland","year":"2000","unstructured":"Haaland, K. Y., Harrington, D. L. & Knight, R. T. Neural representations of skilled movement. Brain 123, 2306\u20132313 (2000).","journal-title":"Brain"},{"key":"17702_CR46","doi-asserted-by":"publisher","first-page":"3473","DOI":"10.1002\/hbm.24188","volume":"39","author":"NN Kleineberg","year":"2018","unstructured":"Kleineberg, N. N. et al. Action and semantic tool knowledge\u2014Effective connectivity in the underlying neural networks. Hum. Brain Mapp. 39, 3473\u20133486 (2018).","journal-title":"Hum. Brain Mapp."},{"key":"17702_CR47","doi-asserted-by":"crossref","unstructured":"Amedi, A., Malach, R., Hendler, T., Peled, S. & Zohary, E. Visuo-haptic object-related activation in the ventral visual pathway. http:\/\/neurosci.nature.com (2001).","DOI":"10.1038\/85201"},{"key":"17702_CR48","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.neuropsychologia.2011.10.017","volume":"50","author":"PM Gough","year":"2012","unstructured":"Gough, P. M. et al. Nouns referring to tools and natural objects differentially modulate the motor system. Neuropsychologia 50, 19\u201325 (2012).","journal-title":"Neuropsychologia"},{"key":"17702_CR49","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3390\/brainsci12010097","volume":"12","author":"E Visani","year":"2022","unstructured":"Visani, E. et al. The semantics of natural objects and tools in the brain: A combined behavioral and MEG study. Brain Sci. 12, 97 (2022).","journal-title":"Brain Sci."},{"key":"17702_CR50","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: A practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B (Methodol.) 57, 289\u2013300 (1995).","journal-title":"J. R. Stat. Soc. Ser. B (Methodol.)"},{"key":"17702_CR51","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/hbm.20396","volume":"29","author":"E Shikata","year":"2008","unstructured":"Shikata, E. et al. Localization of human intraparietal areas AIP, CIP, and LIP using surface orientation and saccadic eye movement tasks. Hum. Brain Mapp. 29, 411\u2013421 (2008).","journal-title":"Hum. Brain Mapp."},{"key":"17702_CR52","doi-asserted-by":"publisher","first-page":"42","DOI":"10.20982\/tqmp.01.1.p042","volume":"1","author":"D Cousineau","year":"2005","unstructured":"Cousineau, D. Confidence intervals in within-subject designs: Asimpler solution to Loftus and Masson\u2019s method. Tutor. Quant. Methods Psychol. 1, 42\u201345 (2005).","journal-title":"Tutor. Quant. Methods Psychol."},{"key":"17702_CR53","doi-asserted-by":"publisher","first-page":"61","DOI":"10.20982\/tqmp.04.2.p061","volume":"4","author":"RD Morey","year":"2008","unstructured":"Morey, R. D. Confidence intervals from normalized data: A correction to Cousineau (2005). Tutor. Quant. Methods Psychol. 4, 61 (2008).","journal-title":"Tutor. Quant. Methods Psychol."},{"key":"17702_CR54","doi-asserted-by":"publisher","first-page":"14826","DOI":"10.1073\/pnas.94.26.14826","volume":"94","author":"D Malonek","year":"1997","unstructured":"Malonek, D. et al. Vascular imprints of neuronal activity: Relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation. Proc. Natl. Acad. Sci. 94, 14826\u201314831 (1997).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"17702_CR55","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1006\/nimg.2002.1227","volume":"17","author":"G Strangman","year":"2002","unstructured":"Strangman, G., Culver, J. P., Thompson, J. H. & Boas, D. A. A quantitative comparison of simultaneous BOLD fMRI and NIRS recordings during functional brain activation. Neuroimage 17, 719\u2013731 (2002).","journal-title":"Neuroimage"},{"key":"17702_CR56","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1212\/WNL.50.5.1253","volume":"50","author":"F Binkofski","year":"1998","unstructured":"Binkofski, F. et al. Human anterior intraparietal area subserves prehension: A combined lesion and functional MRI activation study. Neurology 50, 1253\u20131259 (1998).","journal-title":"Neurology"},{"key":"17702_CR57","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1093\/brain\/111.3.643","volume":"111","author":"MT Perenin","year":"1988","unstructured":"Perenin, M. T. & Vighetto, A. Optic ataxia: A specific disruption in visuomotor mechanisms: I. Different aspects of the deficit in reaching for objects. Brain 111, 643\u2013674 (1988).","journal-title":"Brain"},{"key":"17702_CR58","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.neuropsychologia.2016.10.003","volume":"98","author":"EB Barbeau","year":"2017","unstructured":"Barbeau, E. B. et al. The role of the left inferior parietal lobule in second language learning: An intensive language training fMRI study. Neuropsychologia 98, 169\u2013176 (2017).","journal-title":"Neuropsychologia"},{"key":"17702_CR59","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nn1873","volume":"10","author":"MS Christensen","year":"2007","unstructured":"Christensen, M. S. et al. Premotor cortex modulates somatosensory cortex during voluntary movements without proprioceptive feedback. Nat. Neurosci. 10, 417\u2013419 (2007).","journal-title":"Nat. Neurosci."},{"key":"17702_CR60","doi-asserted-by":"publisher","first-page":"8176","DOI":"10.1523\/JNEUROSCI.1641-06.2006","volume":"26","author":"NJ Rice","year":"2006","unstructured":"Rice, N. J., Tunik, E. & Grafton, S. T. The anterior intraparietal sulcus mediates grasp execution, independent of requirement to update: new insights from transcranial magnetic stimulation. J. Neurosci. 26, 8176\u20138182 (2006).","journal-title":"J. Neurosci."},{"key":"17702_CR61","doi-asserted-by":"publisher","first-page":"T77","DOI":"10.1016\/j.neuroimage.2007.03.026","volume":"36","author":"E Tunik","year":"2007","unstructured":"Tunik, E., Rice, N. J., Hamilton, A. & Grafton, S. T. Beyond grasping: Representation of action in human anterior intraparietal sulcus. Neuroimage 36, T77\u2013T86 (2007).","journal-title":"Neuroimage"},{"key":"17702_CR62","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1016\/j.neuropsychologia.2008.07.014","volume":"47","author":"G Goldenberg","year":"2009","unstructured":"Goldenberg, G. Apraxia and the parietal lobes. Neuropsychologia 47, 1449\u20131459 (2009).","journal-title":"Neuropsychologia"},{"key":"17702_CR63","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.tics.2020.04.003","volume":"24","author":"EHF de Haan","year":"2020","unstructured":"de Haan, E. H. F. & Dijkerman, H. C. Somatosensation in the brain: A theoretical re-evaluation and a new model. Trends Cogn. Sci. 24, 529\u2013541 (2020).","journal-title":"Trends Cogn. Sci."},{"key":"17702_CR64","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3389\/fnhum.2017.00072","volume":"11","author":"H O\u2019Shea","year":"2017","unstructured":"O\u2019Shea, H. & Moran, A. Does motor simulation theory explain the cognitive mechanisms underlying motor imagery? A critical review. Front. Hum. Neurosci. 11, 72 (2017).","journal-title":"Front. Hum. Neurosci."},{"key":"17702_CR65","doi-asserted-by":"publisher","first-page":"558","DOI":"10.3758\/BF03196313","volume":"9","author":"AM Glenberg","year":"2002","unstructured":"Glenberg, A. M. & Kaschak, M. P. Grounding language in action. Psychon. Bull. Rev. 9, 558\u2013565 (2002).","journal-title":"Psychon. Bull. Rev."},{"key":"17702_CR66","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/S0896-6273(03)00838-9","volume":"41","author":"O Hauk","year":"2004","unstructured":"Hauk, O., Johnsrude, I. & Pulverm\u00fcller, F. Somatotopic representation of action words in human motor and premotor cortex. Neuron 41, 301\u2013307 (2004).","journal-title":"Neuron"},{"key":"17702_CR67","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1162\/0898929053124965","volume":"17","author":"M Tettamanti","year":"2005","unstructured":"Tettamanti, M. et al. Listening to action-related sentences activates fronto-parietal motor circuits. J. Cogn. Neurosci. 17, 273\u2013281 (2005).","journal-title":"J. Cogn. Neurosci."},{"key":"17702_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1037\/0096-3445.135.1.1","volume":"135","author":"RA Zwaan","year":"2006","unstructured":"Zwaan, R. A. & Taylor, L. J. Seeing, acting, understanding: Motor resonance in language comprehension. J. Exp. Psychol. Gen. 135, 1\u201311 (2006).","journal-title":"J. Exp. Psychol. Gen."},{"key":"17702_CR69","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.neuropsychologia.2014.04.004","volume":"59","author":"C Lee","year":"2014","unstructured":"Lee, C., Mirman, D. & Buxbaum, L. J. Abnormal dynamics of activation of object use information in apraxia: Evidence from eyetracking. Neuropsychologia 59, 13\u201326 (2014).","journal-title":"Neuropsychologia"},{"key":"17702_CR70","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1093\/cercor\/bhy134","volume":"29","author":"F Garbarini","year":"2019","unstructured":"Garbarini, F. et al. To move or not to move? Functional role of ventral premotor cortex in motor monitoring during limb immobilization. Cereb. Cortex 29, 273\u2013282 (2019).","journal-title":"Cereb. Cortex"},{"key":"17702_CR71","unstructured":"Berti, A. et al. Shared Cortical Anatomy for Motor Awareness and Motor Control. https:\/\/www.science.org."},{"key":"17702_CR72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-14517-4","volume":"11","author":"L Fornia","year":"2020","unstructured":"Fornia, L. et al. Direct electrical stimulation of the premotor cortex shuts down awareness of voluntary actions. Nat. Commun. 11, 1 (2020).","journal-title":"Nat. Commun."},{"key":"17702_CR73","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1162\/jocn_a_00950","volume":"28","author":"N Bolognini","year":"2016","unstructured":"Bolognini, N., Zigiotto, L., Carneiro, M. I. S. & Vallar, G. \u201cHow did I make It?\u201d: Uncertainty about own motor performance after inhibition of the premotor cortex. J. Cogn. Neurosci. 28, 1052\u20131061 (2016).","journal-title":"J. Cogn. Neurosci."},{"key":"17702_CR74","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.bandl.2013.01.012","volume":"125","author":"PM Gough","year":"2013","unstructured":"Gough, P. M., Campione, G. C. & Buccino, G. Fine tuned modulation of the motor system by adjectives expressing positive and negative properties. Brain Lang. 125, 54\u201359 (2013).","journal-title":"Brain Lang."},{"key":"17702_CR75","doi-asserted-by":"publisher","first-page":"e12953","DOI":"10.1111\/cogs.12953","volume":"45","author":"G Garofalo","year":"2021","unstructured":"Garofalo, G., Marino, B. F. M., Bellelli, S. & Riggio, L. Adjectives modulate sensorimotor activation driven by nouns. Cognit. Sci. 45, e12953 (2021).","journal-title":"Cognit. Sci."},{"key":"17702_CR76","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/j.concog.2012.09.001","volume":"21","author":"F Anelli","year":"2012","unstructured":"Anelli, F., Borghi, A. M. & Nicoletti, R. Grasping the pain: Motor resonance with dangerous affordances. Conscious. Cogn. 21, 1627\u20131639 (2012).","journal-title":"Conscious. Cogn."},{"key":"17702_CR77","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00344","author":"F Anelli","year":"2013","unstructured":"Anelli, F., Nicoletti, R., Bolzani, R. & Borghi, A. M. Keep away from danger: Dangerous objects in dynamic and static situations. Front. Hum. Neurosci. https:\/\/doi.org\/10.3389\/fnhum.2013.00344 (2013).","journal-title":"Front. Hum. Neurosci."},{"key":"17702_CR78","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s00221-013-3577-2","volume":"228","author":"F Anelli","year":"2013","unstructured":"Anelli, F., Ranzini, M., Nicoletti, R. & Borghi, A. M. Perceiving object dangerousness: An escape from pain?. Exp. Brain Res. 228, 457\u2013466 (2013).","journal-title":"Exp. Brain Res."},{"key":"17702_CR79","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3758\/BF03193146","volume":"39","author":"F Faul","year":"2007","unstructured":"Faul, F., Erdfelder, E., Lang, A. G. & Buchner, A. G* Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav. Res. Methods 39, 175\u2013191 (2007).","journal-title":"Behav. Res. Methods"},{"key":"17702_CR80","unstructured":"Amano, S. & Kondo, K. NTT Psycholinguistic Databases \u201cLexical Properties of Japanese\u201d (Vol.7, frequency) (San-seido, 2000)."},{"key":"17702_CR81","unstructured":"Sakuma, N. et al. NTT Psycholinguistic Databases \u201cLexical Properties of Japanese\u201d (Vol.8 ,words, imaginability). (San-seido, 2008)."},{"key":"17702_CR82","first-page":"9","volume":"100","author":"N Sakuma","year":"2000","unstructured":"Sakuma, N. et al. Imageability ratings for 50, 000 Japanese words\u202f: Two rating experiments of visual and auditory presentation. IEICE Tech. Rep. (Thought Lang.) 100, 9\u201316 (2000).","journal-title":"IEICE Tech. Rep. (Thought Lang.)"},{"key":"17702_CR83","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1163\/156856897X00357","volume":"10","author":"DH Brainard","year":"1997","unstructured":"Brainard, D. H. The psychophysics toolbox. Spat. Vis. 10, 433\u2013436 (1997).","journal-title":"Spat. Vis."},{"key":"17702_CR84","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1163\/156856897X00366","volume":"10","author":"DG Pelli","year":"1997","unstructured":"Pelli, D. G. The VideoToolbox software for visual psychophysics: transforming numbers into movies. Spat. Vis. 10, 437\u2013442 (1997).","journal-title":"Spat. Vis."},{"key":"17702_CR85","unstructured":"Kleiner, M., Brainard, D. & Pelli, D. What\u2019s new in Psychtoolbox-3? Perception 36 ECVP Abstract Supplement (2007)."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-17702-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-17702-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-17702-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T23:53:36Z","timestamp":1727740416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-17702-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,8]]},"references-count":85,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["17702"],"URL":"https:\/\/doi.org\/10.1038\/s41598-022-17702-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,8]]},"assertion":[{"value":"25 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"13545"}}