{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:10:41Z","timestamp":1791465041511,"version":"4.3.4"},"reference-count":106,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Science, Technology and Innovation Funding Authority","award":["34908"],"award-info":[{"award-number":["34908"]}]},{"name":"Science, Technology and Innovation Funding Authority","award":["34908"],"award-info":[{"award-number":["34908"]}]},{"name":"Science, Technology and Innovation Funding Authority","award":["34908"],"award-info":[{"award-number":["34908"]}]},{"name":"Science, Technology and Innovation Funding Authority","award":["34908"],"award-info":[{"award-number":["34908"]}]},{"name":"Science, Technology and Innovation Funding Authority","award":["34908"],"award-info":[{"award-number":["34908"]}]},{"name":"Science, Technology and Innovation Funding Authority","award":["34908"],"award-info":[{"award-number":["34908"]}]},{"name":"Science, Technology and Innovation Funding Authority","award":["34908"],"award-info":[{"award-number":["34908"]}]},{"name":"Science, Technology and Innovation Funding Authority","award":["34908"],"award-info":[{"award-number":["34908"]}]},{"name":"Suez Canal University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitiligo is considered a disabling disease that affects physical, social, psychological, and occupational aspects of an individual's quality of life. The search for non-invasive and reliable biomarkers for vitiligo's early diagnosis, prognosis, and treatment prediction is under intensive investigation. There is currently an emerging interest in employing miRNAs as biomarkers to predict vitiligo diagnosis and prognosis, inspired by the well-preserved nature of miRNAs in serum or plasma. In the current study, we assessed a panel of 20 melanogenesis pathway-related microRNAs (miRNAs) using quantitative real-time PCR technique in 85 non-segmental vitiligo (NSV) patients compared to 85 normal controls followed by function and pathway enrichment analysis for the miRNAs with significant results. Twelve out of the 20 circulating miRNAs showed significantly higher expression levels in vitiligo patients relative to controls where miR-423 show the highest expression level followed by miR-182, miR-106a, miR-23b, miR-9, miR-124, miR-130a, miR-203a, miR-181, miR-152, and miR-320a. While six miRNAs (miR-224, miR-148a, miR-137, and miR-7, miR-148b, miR-145, miR-374b, and miR-196b) didn\u2019t show significant expression level. The analysis of the receiver operating curve indicated that miR-423, miR-106a, and miR-182 were outstanding biomarkers with the highest areas under the curve in vitiligo. This study is the first Egyptian study to investigate a panel of miRNAs expression profile in the plasma of patients with NSV. Our results suggest that specific circulating miRNAs signature might be implicated in vitiligo pathogenesis and could potentially be used as biomarkers in vitiligo.<\/jats:p>","DOI":"10.1038\/s41598-022-17770-3","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T10:03:08Z","timestamp":1659952988000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Investigating melanogenesis-related microRNAs as disease biomarkers in vitiligo"],"prefix":"10.1038","volume":"12","author":[{"given":"Hoda Y.","family":"Abdallah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noura R.","family":"Abdelhamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman A.","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal Y.","family":"AbdElWahab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha Z.","family":"Tawfik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal H. A.","family":"Gomaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman A.","family":"Toraih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alia","family":"Ellawindy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"issue":"3","key":"17770_CR1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.4103\/0378-6323.32708","volume":"73","author":"V Sehgal","year":"2007","unstructured":"Sehgal, V. & Srivastava, G. Vitiligo: Compendium of clinico-epidemiological features. Indian J. Dermatol. Venereol. Leprol. 73(3), 149. https:\/\/doi.org\/10.4103\/0378-6323.32708 (2007).","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"issue":"6","key":"17770_CR2","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1111\/j.1365-2133.2005.06456.x","volume":"152","author":"K Ongenae","year":"2005","unstructured":"Ongenae, K., Van Geel, N., De Schepper, S. & Naeyaert, J. M. Effect of vitiligo on self-reported health-related quality of life. Br. J. Dermatol. 152(6), 1165\u20131172. https:\/\/doi.org\/10.1111\/j.1365-2133.2005.06456.x (2005).","journal-title":"Br. J. Dermatol."},{"issue":"3","key":"17770_CR3","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1111\/pcmr.12086","volume":"26","author":"Y-L Shi","year":"2013","unstructured":"Shi, Y.-L. et al. MicroRNA expression profiling identifies potential serum biomarkers for non-segmental vitiligo. Pigment Cell Melanoma Res. 26(3), 418\u2013421. https:\/\/doi.org\/10.1111\/pcmr.12086 (2013).","journal-title":"Pigment Cell Melanoma Res."},{"key":"17770_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/9781118937303.ch3","volume-title":"Epidemiology of Vitiligo","author":"N Aboul-Fettouh","year":"2018","unstructured":"Aboul-Fettouh, N. & Pandya, A. G. Epidemiology of Vitiligo (Medical and Surgical Management, Vitiligo, 2018). https:\/\/doi.org\/10.1002\/9781118937303.ch3."},{"key":"17770_CR5","doi-asserted-by":"publisher","first-page":"E18","DOI":"10.1038\/skinbio.2011.7","volume":"131","author":"RA Spritz","year":"2011","unstructured":"Spritz, R. A. The genetics of vitiligo. J. Investig. Dermatol. 131, E18\u2013E20. https:\/\/doi.org\/10.1038\/skinbio.2011.7 (2011).","journal-title":"J. Investig. Dermatol."},{"issue":"2","key":"17770_CR6","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1111\/pcmr.12949","volume":"34","author":"J Seneschal","year":"2021","unstructured":"Seneschal, J., Boniface, K., D\u2019Arino, A. & Picardo, M. An update on Vitiligo pathogenesis. Pigment Cell Melanoma Res. 34(2), 236\u2013243. https:\/\/doi.org\/10.1111\/pcmr.12949 (2021).","journal-title":"Pigment Cell Melanoma Res."},{"issue":"1","key":"17770_CR7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12864-017-3510-3","volume":"18","author":"R Dey-Rao","year":"2017","unstructured":"Dey-Rao, R. & Sinha, A. A. Vitiligo blood transcriptomics provides new insights into disease mechanisms and identifies potential novel therapeutic targets. BMC Genom. 18(1), 109. https:\/\/doi.org\/10.1186\/s12864-017-3510-3 (2017).","journal-title":"BMC Genom."},{"issue":"3","key":"17770_CR8","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.jaad.2019.07.036","volume":"82","author":"A Hadi","year":"2020","unstructured":"Hadi, A., Wang, J. F., Uppal, P., Penn, L. A. & Elbuluk, N. Comorbid diseases of vitiligo: A 10-year cross-sectional retrospective study of an urban US population. J. Am. Acad. Dermatol. 82(3), 628\u2013633. https:\/\/doi.org\/10.1016\/j.jaad.2019.07.036 (2020).","journal-title":"J. Am. Acad. Dermatol."},{"issue":"5","key":"17770_CR9","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/j.1600-0749.2006.00333.x","volume":"19","author":"ML Dell\u2019anna","year":"2006","unstructured":"Dell\u2019anna, M. L., & Picardo, M.,. A review and a new hypothesis for non-immunological pathogenetic mechanisms in vitiligo. Pigment Cell Res. 19(5), 406\u2013411. https:\/\/doi.org\/10.1111\/j.1600-0749.2006.00333.x (2006).","journal-title":"Pigment Cell Res."},{"issue":"4","key":"17770_CR10","doi-asserted-by":"publisher","first-page":"247","DOI":"10.5114\/pdia.2014.43497","volume":"31","author":"R Czajkowski","year":"2014","unstructured":"Czajkowski, R. & M\u0119ci\u0144ska-Jundzi\u0142\u0142, K. Current aspects of vitiligo genetics. Postepy Dermatologii i Alergologii 31(4), 247\u2013255. https:\/\/doi.org\/10.5114\/pdia.2014.43497 (2014).","journal-title":"Postepy Dermatologii i Alergologii"},{"issue":"2","key":"17770_CR11","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.det.2016.11.013","volume":"35","author":"RA Spritz","year":"2017","unstructured":"Spritz, R. A. & Andersen, G. H. L. Genetics of vitiligo. Dermatol. Clin. 35(2), 245\u2013255. https:\/\/doi.org\/10.1016\/j.det.2016.11.013 (2017).","journal-title":"Dermatol. Clin."},{"issue":"6","key":"17770_CR12","doi-asserted-by":"publisher","first-page":"742","DOI":"10.2340\/00015555-2394","volume":"96","author":"L \u0160ahmatova","year":"2016","unstructured":"\u0160ahmatova, L. et al. MicroRNA-155 is dysregulated in the skin of patients with vitiligo and inhibits melanogenesis-associated genes in melanocytes and keratinocytes. Acta Derm. Venereol. 96(6), 742\u2013747. https:\/\/doi.org\/10.2340\/00015555-2394 (2016).","journal-title":"Acta Derm. Venereol."},{"issue":"3","key":"17770_CR13","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1038\/oncsis.2012.3","volume":"1","author":"E Sonkoly","year":"2012","unstructured":"Sonkoly, E. et al. MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma. Oncogenesis 1(3), e3\u2013e3. https:\/\/doi.org\/10.1038\/oncsis.2012.3 (2012).","journal-title":"Oncogenesis"},{"issue":"2","key":"17770_CR14","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/1346-8138.12725","volume":"42","author":"Y Wang","year":"2015","unstructured":"Wang, Y. et al. Differential expression analysis of mi RNA in peripheral blood mononuclear cells of patients with non-segmental vitiligo. J. Dermatol. 42(2), 193\u2013197. https:\/\/doi.org\/10.1111\/1346-8138.12725 (2015).","journal-title":"J. Dermatol."},{"issue":"10","key":"17770_CR15","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1111\/1346-8138.13886","volume":"44","author":"Z Shang","year":"2017","unstructured":"Shang, Z. & Li, H. Altered expression of four mi RNA (miR-1238-3p, miR-202-3p, miR-630 and miR-766-3p) and their potential targets in peripheral blood from vitiligo patients. J. Dermatol. 44(10), 1138\u20131144. https:\/\/doi.org\/10.1111\/1346-8138.13886 (2017).","journal-title":"J. Dermatol."},{"issue":"8","key":"17770_CR16","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s00403-015-1563-1","volume":"307","author":"T-T Cui","year":"2015","unstructured":"Cui, T.-T. et al. miR-196a-2 rs11614913 polymorphism is associated with vitiligo by affecting heterodimeric molecular complexes of Tyr and Tyrp1. Arch. Dermatol. Res. 307(8), 683\u2013692. https:\/\/doi.org\/10.1007\/s00403-015-1563-1 (2015).","journal-title":"Arch. Dermatol. Res."},{"issue":"1","key":"17770_CR17","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jdermsci.2016.07.003","volume":"84","author":"MS Mansuri","year":"2016","unstructured":"Mansuri, M. S., Singh, M. & Begum, R. miRNA signatures and transcriptional regulation of their target genes in vitiligo. J. Dermatol. Sci. 84(1), 50\u201358. https:\/\/doi.org\/10.1016\/j.jdermsci.2016.07.003 (2016).","journal-title":"J. Dermatol. Sci."},{"issue":"Special Issue","key":"17770_CR18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.24870\/cjb.2017-a32","volume":"1","author":"R Rahman","year":"2017","unstructured":"Rahman, R. & Hasija, Y. An integrated genomic analysis on miRNAs and SNPs associated with vitiligo to reveal potential drug candidates. Can. J. Biotechnol. 1(Special Issue), 45. https:\/\/doi.org\/10.24870\/cjb.2017-a32 (2017).","journal-title":"Can. J. Biotechnol."},{"issue":"1","key":"17770_CR19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2500\/aap.2017.38.4013","volume":"38","author":"C Mannucci","year":"2017","unstructured":"Mannucci, C. et al. Involvement of microRNAs in skin disorders: A literature review. Allergy Asthma Proc. 38(1), 9\u201315. https:\/\/doi.org\/10.2500\/aap.2017.38.4013 (2017).","journal-title":"Allergy Asthma Proc."},{"issue":"W1","key":"17770_CR20","doi-asserted-by":"publisher","first-page":"W460","DOI":"10.1093\/nar\/gkv403","volume":"43","author":"IS Vlachos","year":"2015","unstructured":"Vlachos, I. S. et al. DIANA-miRPath v3.0: Deciphering microRNA function with experimental support. Nucleic Acids Res. 43(W1), W460\u2013W466. https:\/\/doi.org\/10.1093\/nar\/gkv403 (2015).","journal-title":"Nucleic Acids Res."},{"issue":"suppl_1","key":"17770_CR21","doi-asserted-by":"publisher","first-page":"D149","DOI":"10.1093\/nar\/gkm995","volume":"36","author":"D Betel","year":"2008","unstructured":"Betel, D., Wilson, M., Gabow, A., Marks, D. S. & Sander, C. The microRNA org resource: Targets and expression. Nucleic Acids Res. 36(suppl_1), D149\u2013D153. https:\/\/doi.org\/10.1093\/nar\/gkm995 (2008).","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"17770_CR22","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method. Methods 25(4), 402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262 (2001).","journal-title":"Methods"},{"issue":"3","key":"17770_CR23","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1089\/omi.2015.0168","volume":"20","author":"B-A Fuchs","year":"2016","unstructured":"Fuchs, B.-A. et al. GeneAnalytics: An integrative gene set analysis tool for next generation sequencing, RNAseq and microarray data. Omics J. Integr. Biol. 20(3), 139\u2013151. https:\/\/doi.org\/10.1089\/omi.2015.0168 (2016).","journal-title":"Omics J. Integr. Biol."},{"issue":"suppl_2","key":"17770_CR24","doi-asserted-by":"publisher","first-page":"W193","DOI":"10.1093\/nar\/gkm226","volume":"35","author":"J Reimand","year":"2007","unstructured":"Reimand, J., Kull, M., Peterson, H., Hansen, J. & Vilo, J. Profiler-a web-based toolset for functional profiling of gene lists from large-scale experiments. Nucleic Acids Res. 35(suppl_2), W193\u2013W200. https:\/\/doi.org\/10.1093\/nar\/gkm226 (2007).","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"17770_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nar\/gkn923","volume":"37","author":"DW Huang","year":"2009","unstructured":"Huang, D. W., Sherman, B. T. & Lempicki, R. A. Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37(1), 1\u201313. https:\/\/doi.org\/10.1093\/nar\/gkn923 (2009).","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"17770_CR26","doi-asserted-by":"publisher","first-page":"W409","DOI":"10.1093\/nar\/gkab297","volume":"49","author":"F Kern","year":"2021","unstructured":"Kern, F. et al. miRTargetLink 2.0-interactive miRNA target gene and target pathway networks. Nucleic Acids Res. 49(W1), W409\u2013W416. https:\/\/doi.org\/10.1093\/nar\/gkab297 (2021).","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"17770_CR27","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.canlet.2014.01.024","volume":"347","author":"J Liu","year":"2014","unstructured":"Liu, J. et al. miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells. Cancer Lett. 347(1), 98\u2013104. https:\/\/doi.org\/10.1016\/j.canlet.2014.01.024 (2014).","journal-title":"Cancer Lett."},{"key":"17770_CR28","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.gene.2018.11.021","volume":"688","author":"H Lin","year":"2019","unstructured":"Lin, H. et al. Inhibition of miR-423-5p suppressed prostate cancer through targeting GRIM-19. Gene 688, 93\u201397. https:\/\/doi.org\/10.1016\/j.gene.2018.11.021 (2019).","journal-title":"Gene"},{"issue":"6","key":"17770_CR29","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1159\/000495085","volume":"50","author":"X Wang","year":"2018","unstructured":"Wang, X. et al. MiR-423-5p inhibits osteosarcoma proliferation and invasion through directly targeting STMN1. Cell. Physiol. Biochem. 50(6), 2249\u20132259. https:\/\/doi.org\/10.1159\/000495085 (2018).","journal-title":"Cell. Physiol. Biochem."},{"key":"17770_CR30","doi-asserted-by":"publisher","first-page":"4723","DOI":"10.3892\/etm.2018.6015","volume":"15","author":"X Tang","year":"2018","unstructured":"Tang, X. et al. miR-423-5p serves as a diagnostic indicator and inhibits the proliferation and invasion of ovarian cancer. Exp. Ther. Med. 15, 4723\u20134730. https:\/\/doi.org\/10.3892\/etm.2018.6015 (2018).","journal-title":"Exp. Ther. Med."},{"issue":"6","key":"17770_CR31","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1161\/CIRCRESAHA.110.218297","volume":"106","author":"AJ Tijsen","year":"2010","unstructured":"Tijsen, A. J. et al. MiR423-5p as a circulating biomarker for heart failure. Circ. Res. 106(6), 1035\u20131039. https:\/\/doi.org\/10.1161\/CIRCRESAHA.110.218297 (2010).","journal-title":"Circ. Res."},{"issue":"5","key":"17770_CR32","doi-asserted-by":"publisher","first-page":"e0216363","DOI":"10.1371\/journal.pone.0216363","volume":"14","author":"B Rizzacasa","year":"2019","unstructured":"Rizzacasa, B. et al. MiR-423 is differentially expressed in patients with stable and unstable coronary artery disease: A pilot study. PLoS ONE 14(5), e0216363. https:\/\/doi.org\/10.1371\/journal.pone.0216363 (2019).","journal-title":"PLoS ONE"},{"key":"17770_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.placenta.2018.12.003","volume":"74","author":"L Guo","year":"2018","unstructured":"Guo, L., Liu, Y., Guo, Y., Yang, Y. & Chen, B. MicroRNA-423-5p inhibits the progression of trophoblast cells via targeting IGF2BP1. Placenta 74, 1\u20138. https:\/\/doi.org\/10.1016\/j.placenta.2018.12.003 (2018).","journal-title":"Placenta"},{"issue":"1","key":"17770_CR34","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1080\/22221751.2019.1590129","volume":"8","author":"H Tu","year":"2019","unstructured":"Tu, H. et al. Elevated pulmonary tuberculosis biomarker miR-423-5p plays critical role in the occurrence of active TB by inhibiting autophagosome-lysosome fusion. Emerg. Microb. Infect. 8(1), 448\u2013460. https:\/\/doi.org\/10.1080\/22221751.2019.1590129 (2019).","journal-title":"Emerg. Microb. Infect."},{"issue":"1","key":"17770_CR35","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1038\/s41598-020-58949-w","volume":"10","author":"U Vaish","year":"2020","unstructured":"Vaish, U. et al. Author Correction: Micro RNAs upregulated in Vitiligo skin play an important role in its aetiopathogenesis by altering TRP1 expression and keratinocyte-melanocytes cross-talk. Sci. Rep. 10(1), 2166. https:\/\/doi.org\/10.1038\/s41598-020-58949-w (2020).","journal-title":"Sci. Rep."},{"issue":"6","key":"17770_CR36","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1073\/pnas.0808263106","volume":"106","author":"MF Segura","year":"2009","unstructured":"Segura, M. F. et al. Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc. Natl. Acad. Sci. U.S.A. 106(6), 1814\u20131819. https:\/\/doi.org\/10.1073\/pnas.0808263106 (2009).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"7","key":"17770_CR37","doi-asserted-by":"publisher","first-page":"e40967","DOI":"10.1371\/journal.pone.0040967","volume":"7","author":"D Yan","year":"2012","unstructured":"Yan, D. et al. Role of microRNA-182 in posterior uveal melanoma: Regulation of tumor development through MITF, BCL2 and cyclin D2. PLoS ONE 7(7), e40967. https:\/\/doi.org\/10.1371\/journal.pone.0040967 (2012).","journal-title":"PLoS ONE"},{"issue":"5","key":"17770_CR38","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1245\/s10434-012-2467-3","volume":"20","author":"S Liu","year":"2013","unstructured":"Liu, S., Howell, P. M. & Riker, A. I. Up-regulation of miR-182 expression after epigenetic modulation of human melanoma cells. Ann. Surg. Oncol. 20(5), 1745\u20131752. https:\/\/doi.org\/10.1245\/s10434-012-2467-3 (2013).","journal-title":"Ann. Surg. Oncol."},{"key":"17770_CR39","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2019.190646","author":"J Ding","year":"2020","unstructured":"Ding, J., Zhu, X., Chen, X., Guan, J. & Li, H. MicroRNA-182 suppresses malignant melanoma proliferation by targeting RECK. Clin. Lab. https:\/\/doi.org\/10.7754\/Clin.Lab.2019.190646 (2020).","journal-title":"Clin. Lab."},{"key":"17770_CR40","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jaut.2005.10.001","volume":"25","author":"T Passeron","year":"2005","unstructured":"Passeron, T. & Ortonne, J.-P. Physiopathology and genetics of vitiligo. J. Autoimmun. 25, 63\u201368. https:\/\/doi.org\/10.1016\/j.jaut.2005.10.001 (2005).","journal-title":"J. Autoimmun."},{"issue":"3","key":"17770_CR41","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s00432-018-2582-z","volume":"144","author":"W Luan","year":"2018","unstructured":"Luan, W. et al. Long non-coding RNA H19 promotes glucose metabolism and cell growth in malignant melanoma via miR-106a-5p\/E2F3 axis. J. Cancer Res. Clin. Oncol. 144(3), 531\u2013542. https:\/\/doi.org\/10.1007\/s00432-018-2582-z (2018).","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"3","key":"17770_CR42","doi-asserted-by":"publisher","first-page":"965","DOI":"10.26355\/eurrev_201902_16983","volume":"23","author":"J-L Wang","year":"2019","unstructured":"Wang, J.-L., Li, H., Zhang, J.-B., Zhang, C.-H. & Hou, X.-Q. Suppression of connexin 43 expression by miR-106a promotes melanoma cell proliferation. Eur. Rev. Med. Pharmacol. Sci. 23(3), 965\u2013971. https:\/\/doi.org\/10.26355\/eurrev_201902_16983 (2019).","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"1","key":"17770_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1134\/s1990519x17010072","volume":"11","author":"NV Palkina","year":"2017","unstructured":"Palkina, N. V., Komina, A. V., Aksenenko, M. B. & Ruksha, T. G. The pro-oncogenic effect of miR-106a microRNA inhibition in melanoma cells in vitro. Cell Tissue Biol. 11(1), 1\u20138. https:\/\/doi.org\/10.1134\/s1990519x17010072 (2017).","journal-title":"Cell Tissue Biol."},{"key":"17770_CR44","doi-asserted-by":"publisher","unstructured":"Miao, X., Tong, X., Hu, J. & Wang, J. Diagnostic value of miR-106a-5p in patients with psoriasis and its regulatory role in inflammatory responses. In Research Square. https:\/\/doi.org\/10.21203\/rs.3.rs-60976\/v1 (2020).","DOI":"10.21203\/rs.3.rs-60976\/v1"},{"issue":"1","key":"17770_CR45","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jdermsci.2019.11.003","volume":"97","author":"D Deli\u0107","year":"2020","unstructured":"Deli\u0107, D. et al. Integrated microRNA\/mRNA expression profiling of the skin of psoriasis patients. J. Dermatol. Sci. 97(1), 9\u201320. https:\/\/doi.org\/10.1016\/j.jdermsci.2019.11.003 (2020).","journal-title":"J. Dermatol. Sci."},{"issue":"7","key":"17770_CR46","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1074\/jbc.m116.769893","volume":"292","author":"A Torri","year":"2017","unstructured":"Torri, A. et al. Extracellular MicroRNA signature of human helper T cell subsets in health and autoimmunity. J. Biol. Chem. 292(7), 2903\u20132915. https:\/\/doi.org\/10.1074\/jbc.m116.769893 (2017).","journal-title":"J. Biol. Chem."},{"issue":"11","key":"17770_CR47","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1007\/s00109-014-1208-4","volume":"92","author":"V Viswanathan","year":"2014","unstructured":"Viswanathan, V., Fields, J. & Boman, B. M. The miRNA23b-regulated signaling network as a key to cancer development\u2014implications for translational research and therapeutics. J. Mol. Med. 92(11), 1129\u20131138. https:\/\/doi.org\/10.1007\/s00109-014-1208-4 (2014).","journal-title":"J. Mol. Med."},{"key":"17770_CR48","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6473038","author":"G Yu-Xin","year":"2021","unstructured":"Yu-Xin, G. et al. The role of miR-23b in cancer and autoimmune disease. J. Oncol. https:\/\/doi.org\/10.1155\/2021\/6473038 (2021).","journal-title":"J. Oncol."},{"issue":"7","key":"17770_CR49","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/nm.2849","volume":"18","author":"R Hu","year":"2012","unstructured":"Hu, R. & O\u2019Connell, R. M. MiR-23b is a safeguard against autoimmunity. Nat. Med. 18(7), 1009\u20131010. https:\/\/doi.org\/10.1038\/nm.2849 (2012).","journal-title":"Nat. Med."},{"issue":"3","key":"17770_CR50","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1111\/bjd.20804","volume":"186","author":"G Vellaichamy","year":"2022","unstructured":"Vellaichamy, G. et al. An in vivo model of postinflammatory hyperpigmentation and erythema: Clinical, colorimetric and molecular characteristics. Br. J. Dermatol. 186(3), 508\u2013519. https:\/\/doi.org\/10.1111\/bjd.20804 (2022).","journal-title":"Br. J. Dermatol."},{"issue":"9","key":"17770_CR51","doi-asserted-by":"publisher","first-page":"e72699","DOI":"10.1371\/journal.pone.0072699","volume":"8","author":"J Kozubek","year":"2013","unstructured":"Kozubek, J. et al. In-depth characterization of microRNA transcriptome in melanoma. PLoS ONE 8(9), e72699. https:\/\/doi.org\/10.1371\/journal.pone.0072699 (2013).","journal-title":"PLoS ONE"},{"issue":"2","key":"17770_CR52","doi-asserted-by":"publisher","first-page":"197","DOI":"10.17305\/bjbms.2019.4271","volume":"20","author":"I Gencia","year":"2020","unstructured":"Gencia, I. et al. A preliminary study of microRNA expression in different types of primary melanoma. Bosn. J. Basic Med. Sci. 20(2), 197\u2013208. https:\/\/doi.org\/10.17305\/bjbms.2019.4271 (2020).","journal-title":"Bosn. J. Basic Med. Sci."},{"issue":"10","key":"17770_CR53","doi-asserted-by":"publisher","first-page":"541","DOI":"10.2217\/fon-2019-0699","volume":"16","author":"R Lv","year":"2020","unstructured":"Lv, R., Yu, J. & Sun, Q. Anti-angiogenic role of microRNA-23b in melanoma by disturbing NF-\u03baB signaling pathway via targeted inhibition of NAMPT. Future Oncol. (Lond. Engl.) 16(10), 541\u2013458. https:\/\/doi.org\/10.2217\/fon-2019-0699 (2020).","journal-title":"Future Oncol. (Lond. Engl.)"},{"issue":"7","key":"17770_CR54","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1038\/nm.2815","volume":"18","author":"S Zhu","year":"2012","unstructured":"Zhu, S. et al. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-\u03b1. Nat. Med. 18(7), 1077\u20131086. https:\/\/doi.org\/10.1038\/nm.2815 (2012).","journal-title":"Nat. Med."},{"issue":"2","key":"17770_CR55","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.cyto.2013.03.014","volume":"62","author":"X Song","year":"2013","unstructured":"Song, X. & Qian, Y. The activation and regulation of IL-17 receptor mediated signaling. Cytokine 62(2), 175\u2013182. https:\/\/doi.org\/10.1016\/j.cyto.2013.03.014 (2013).","journal-title":"Cytokine"},{"issue":"143911","key":"17770_CR56","doi-asserted-by":"publisher","first-page":"143911","DOI":"10.1016\/j.gene.2019.06.001","volume":"712","author":"X Liu","year":"2019","unstructured":"Liu, X. et al. Circulating microRNA-23b as a new biomarker for rheumatoid arthritis. Gene 712(143911), 143911. https:\/\/doi.org\/10.1016\/j.gene.2019.06.001 (2019).","journal-title":"Gene"},{"key":"17770_CR57","doi-asserted-by":"publisher","DOI":"10.1186\/s43166-021-00090-1","author":"HM Abdeen","year":"2021","unstructured":"Abdeen, H. M. et al. Micro RNA-23b as a potential biomarker in rheumatoid arthritis disease activity and severity: Clinical, laboratory, and radiological cross-sectional study. Egypt. Rheumatol. Rehabil. https:\/\/doi.org\/10.1186\/s43166-021-00090-1 (2021).","journal-title":"Egypt. Rheumatol. Rehabil."},{"issue":"100955","key":"17770_CR58","doi-asserted-by":"publisher","first-page":"100955","DOI":"10.1016\/j.genrep.2020.100955","volume":"21","author":"YW Issa","year":"2020","unstructured":"Issa, Y. W. & Salih, S. M. Impact of miR-155, miR-145 and miR-328 on pigmentary Process in Iraqi Patients with vitiligo. Gene Rep. 21(100955), 100955. https:\/\/doi.org\/10.1016\/j.genrep.2020.100955 (2020).","journal-title":"Gene Rep."},{"issue":"1","key":"17770_CR59","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/jid.2012.266","volume":"133","author":"P Dynoodt","year":"2013","unstructured":"Dynoodt, P. et al. Identification of miR-145 as a Key regulator of the pigmentary process. J. Investig. Dermatol. 133(1), 201\u2013209. https:\/\/doi.org\/10.1038\/jid.2012.266 (2013).","journal-title":"J. Investig. Dermatol."},{"issue":"6","key":"17770_CR60","doi-asserted-by":"publisher","first-page":"441","DOI":"10.5021\/ad.2020.32.6.441","volume":"32","author":"L Li","year":"2020","unstructured":"Li, L. The role of MicroRNAs in vitiligo: Regulators and therapeutic targets. Ann. Dermatol. 32(6), 441\u2013451. https:\/\/doi.org\/10.5021\/ad.2020.32.6.441 (2020).","journal-title":"Ann. Dermatol."},{"issue":"5","key":"17770_CR61","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1111\/bjd.13109","volume":"171","author":"MS Mansuri","year":"2014","unstructured":"Mansuri, M. S. et al. Micro RNA profiling reveals differentially expressed microRNA signatures from the skin of patients with nonsegmental vitiligo. Br. J. Dermatol. 171(5), 1263\u20131267. https:\/\/doi.org\/10.1111\/bjd.13109 (2014).","journal-title":"Br. J. Dermatol."},{"issue":"12","key":"17770_CR62","doi-asserted-by":"publisher","first-page":"21889","DOI":"10.1002\/jcp.28752","volume":"234","author":"Q Wu","year":"2019","unstructured":"Wu, Q. et al. Long noncoding RNA FOXD3-AS1 promotes colon adenocarcinoma progression and functions as a competing endogenous RNA to regulate SIRT1 by sponging miR-135a-5p. J. Cell. Physiol. 234(12), 21889\u201321902. https:\/\/doi.org\/10.1002\/jcp.28752 (2019).","journal-title":"J. Cell. Physiol."},{"issue":"7","key":"17770_CR63","doi-asserted-by":"publisher","first-page":"415","DOI":"10.18632\/aging.100176","volume":"2","author":"LR Saunders","year":"2010","unstructured":"Saunders, L. R. et al. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging 2(7), 415\u2013431. https:\/\/doi.org\/10.18632\/aging.100176 (2010).","journal-title":"Aging"},{"issue":"3","key":"17770_CR64","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/exd.14487","volume":"31","author":"NMA Raia","year":"2022","unstructured":"Raia, N. M. A., Shaker, O. G., Hassan, Z. M. & Abd Elrahim, T. A. Is there a relation between long non-coding RNA MALAT-1 and miRNA-9 in Egyptian patients with Vitiligo?. Exp. Dermatol. 31(3), 381\u2013383. https:\/\/doi.org\/10.1111\/exd.14487 (2022).","journal-title":"Exp. Dermatol."},{"issue":"1","key":"17770_CR65","doi-asserted-by":"publisher","first-page":"111615","DOI":"10.1016\/j.yexcr.2019.111615","volume":"384","author":"M Su","year":"2019","unstructured":"Su, M. et al. miR-9 regulates melanocytes adhesion and migration during vitiligo repigmentation induced by UVB treatment. Exp. Cell Res. 384(1), 111615. https:\/\/doi.org\/10.1016\/j.yexcr.2019.111615 (2019).","journal-title":"Exp. Cell Res."},{"issue":"5","key":"17770_CR66","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1111\/ijd.13564","volume":"56","author":"M Kidir","year":"2017","unstructured":"Kidir, M., Karabulut, A. A., Ercin, M. E. & Atasoy, P. Regulatory T-cell cytokines in patients with nonsegmental vitiligo. Int. J. Dermatol. 56(5), 581\u2013588. https:\/\/doi.org\/10.1111\/ijd.13564 (2017).","journal-title":"Int. J. Dermatol."},{"issue":"111198","key":"17770_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111198","volume":"135","author":"S Ghafouri-Fard","year":"2021","unstructured":"Ghafouri-Fard, S. et al. An update on the role of miR-124 in the pathogenesis of human disorders. Biomed. Pharmacother. 135(111198), 111198. https:\/\/doi.org\/10.1016\/j.biopha.2020.111198 (2021).","journal-title":"Biomed. Pharmacother."},{"key":"17770_CR68","unstructured":"Nakamachi, Y., Saegusa, J. & Kawano, S. MicroRNA-124: A promising therapeutic agent for various human diseases, including rheumatoid arthritis. RNA & DISEASE, 4. http:\/\/www.smartscitech.com\/index.php\/rd (2017)."},{"key":"17770_CR69","doi-asserted-by":"publisher","first-page":"9975","DOI":"10.2147\/OTT.S225120","volume":"12","author":"C Shen","year":"2019","unstructured":"Shen, C. et al. MiR-124 functions as a melanoma tumor suppressor by targeting RACK1. OncoTargets Ther. 12, 9975\u20139986. https:\/\/doi.org\/10.2147\/OTT.S225120 (2019).","journal-title":"OncoTargets Ther."},{"issue":"3","key":"17770_CR70","first-page":"986","volume":"9","author":"M Gao","year":"2017","unstructured":"Gao, M., Chang, Y., Wang, X., Ban, C. & Zhang, F. Reduction of COX-2 through modulating miR-124\/SPHK1 axis contributes to the antimetastatic effect of alpinumisoflavone in melanoma. Am. J. Transl. Res. 9(3), 986\u2013998 (2017).","journal-title":"Am. J. Transl. Res."},{"issue":"5","key":"17770_CR71","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1158\/1078-0432.CCR-09-2721","volume":"16","author":"MF Segura","year":"2010","unstructured":"Segura, M. F. et al. Melanoma MicroRNA signature predicts post-recurrence survival. Clin. Cancer Res. 16(5), 1577\u20131586. https:\/\/doi.org\/10.1158\/1078-0432.CCR-09-2721 (2010).","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"17770_CR72","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/jid.2012.357","volume":"133","author":"C Luo","year":"2013","unstructured":"Luo, C. et al. MiR-137 inhibits the invasion of melanoma cells through downregulation of multiple oncogenic target genes. J. Invest. Dermatol. 133(3), 768\u2013775. https:\/\/doi.org\/10.1038\/jid.2012.357 (2013).","journal-title":"J. Invest. Dermatol."},{"issue":"9","key":"17770_CR73","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1261\/rna.033977.112\u200c","volume":"18","author":"C Dong","year":"2012","unstructured":"Dong, C. et al. Coat color determination by miR-137 mediated down-regulation of microphthalmia-associated transcription factor in a mouse model. RNA 18(9), 1679\u20131686. https:\/\/doi.org\/10.1261\/rna.033977.112\u200c (2012).","journal-title":"RNA"},{"key":"17770_CR74","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14762","author":"Z Zhang","year":"2022","unstructured":"Zhang, Z., Shen, W., Liu, W. & Lyu, L. Role of miRNAs in melanin metabolism: Implications in melanin-related diseases. J. Cosmet. Dermatol. https:\/\/doi.org\/10.1111\/jocd.14762 (2022).","journal-title":"J. Cosmet. Dermatol."},{"issue":"11","key":"17770_CR75","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1080\/09168451.2016.1200455","volume":"80","author":"S Jiang","year":"2016","unstructured":"Jiang, S., Yu, X. & Dong, C. MiR-137 affects melanin synthesis in mouse melanocyte by repressing the expression of c-Kit and Tyrp2 in SCF\/c-Kit signaling pathway. Biosci. Biotechnol. Biochem. 80(11), 2115\u20132121. https:\/\/doi.org\/10.1080\/09168451.2016.1200455 (2016).","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"4","key":"17770_CR76","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s12282-017-0776-x","volume":"24","author":"H Zhang","year":"2017","unstructured":"Zhang, H., Jiang, L.-H., Sun, D.-W., Li, J. & Ji, Z.-L. The role of miR-130a in cancer. Breast Cancer (Tokyo, Japan) 24(4), 521\u2013527. https:\/\/doi.org\/10.1007\/s12282-017-0776-x (2017).","journal-title":"Breast Cancer (Tokyo, Japan)"},{"issue":"1","key":"17770_CR77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-018-05023-9","volume":"9","author":"H Ishii","year":"2018","unstructured":"Ishii, H. et al. miR-130a and miR-145 reprogram Gr-1+ CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity. Nat. Commun. 9(1), 1\u20135. https:\/\/doi.org\/10.1038\/s41467-018-05023-9 (2018).","journal-title":"Nat. Commun."},{"issue":"22","key":"17770_CR78","doi-asserted-by":"publisher","first-page":"6168","DOI":"10.1158\/0008-5472.can-17-0530","volume":"77","author":"H Wei","year":"2017","unstructured":"Wei, H. et al. miR-130a Deregulates PTEN and Stimulates Tumor Growth. Can. Res. 77(22), 6168\u20136178. https:\/\/doi.org\/10.1158\/0008-5472.can-17-0530 (2017).","journal-title":"Can. Res."},{"key":"17770_CR79","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-021-00377-7","author":"S Wu","year":"2021","unstructured":"Wu, S., Han, M. & Zhang, C. Overexpression of microRNA-130a represses uveal melanoma cell migration and invasion through inactivation of the Wnt\/\u03b2-catenin signaling pathway by downregulating USP6. Cancer Gene Ther. https:\/\/doi.org\/10.1038\/s41417-021-00377-7 (2021).","journal-title":"Cancer Gene Ther."},{"issue":"12","key":"17770_CR80","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.3899\/jrheum.190602","volume":"47","author":"SM Wade","year":"2020","unstructured":"Wade, S. M., McGarry, T., Wade, S. C., Fearon, U. & Veale, D. J. Serum MicroRNA signature as a diagnostic and therapeutic marker in patients with psoriatic arthritis. J. Rheumatol. 47(12), 1760\u20131767. https:\/\/doi.org\/10.3899\/jrheum.190602 (2020).","journal-title":"J. Rheumatol."},{"issue":"9","key":"17770_CR81","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1242\/dev.089649","volume":"140","author":"SJ Jackson","year":"2013","unstructured":"Jackson, S. J. et al. Rapid and widespread suppression of self-renewal by microRNA-203 during epidermal differentiation. Development (Cambridge, England) 140(9), 1882\u20131891. https:\/\/doi.org\/10.1242\/dev.089649 (2013).","journal-title":"Development (Cambridge, England)"},{"key":"17770_CR82","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2147\/ccid.s4181","volume":"1","author":"DT Wu","year":"2008","unstructured":"Wu, D. T., Chen, J. S., Chang, D. C. & Lin, S.-L. Mir-434-5p mediates skin whitening and lightening. Clin. Cosmet. Investig. Dermatol. 1, 19\u201335. https:\/\/doi.org\/10.2147\/ccid.s4181 (2008).","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"issue":"11","key":"17770_CR83","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1038\/jid.2014.231","volume":"134","author":"F Rambow","year":"2014","unstructured":"Rambow, F. et al. miR-330-5p targets tyrosinase and induces depigmentation. J. Invest. Dermatol. 134(11), 2846\u20132849. https:\/\/doi.org\/10.1038\/jid.2014.231 (2014).","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"17770_CR84","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/pcmr.12179","volume":"27","author":"K-H Kim","year":"2014","unstructured":"Kim, K.-H. et al. Novel inhibitory function of miR-125b in melanogenesis. Pigment Cell Melanoma Res. 27(1), 140\u2013144. https:\/\/doi.org\/10.1111\/pcmr.12179 (2014).","journal-title":"Pigment Cell Melanoma Res."},{"issue":"1","key":"17770_CR85","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/jid.2009.294","volume":"130","author":"E Sonkoly","year":"2010","unstructured":"Sonkoly, E. et al. Protein kinase C-dependent upregulation of miR-203 induces the differentiation of human keratinocytes. J. Invest. Dermatol. 130(1), 124\u2013134. https:\/\/doi.org\/10.1038\/jid.2009.294 (2010).","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"17770_CR86","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1128\/mcb.19.3.1768","volume":"19","author":"G Fritz","year":"1999","unstructured":"Fritz, G. & Kaina, B. Activation of c-jun N-terminal kinase 1 by UV irradiation is inhibited by wortmannin without affecting c- jun expression. Mol. Cell. Biol. 19(3), 1768\u20131774. https:\/\/doi.org\/10.1128\/mcb.19.3.1768 (1999).","journal-title":"Mol. Cell. Biol."},{"issue":"1\u20132","key":"17770_CR87","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/s1011-1344(96)07340-x","volume":"37","author":"M Garmyn","year":"1997","unstructured":"Garmyn, M. & Degreef, H. Suppression of UVB-induced c-fos and c-jun expression in human keratinocytes by N-acetylcysteine. J. Photochem. Photobiol. B Biol. 37(1\u20132), 125\u2013130. https:\/\/doi.org\/10.1016\/s1011-1344(96)07340-x (1997).","journal-title":"J. Photochem. Photobiol. B Biol."},{"issue":"7","key":"17770_CR88","doi-asserted-by":"publisher","first-page":"e610","DOI":"10.1371\/journal.pone.0000610","volume":"2","author":"E Sonkoly","year":"2007","unstructured":"Sonkoly, E. et al. MicroRNAs: Novel regulators involved in the pathogenesis of psoriasis?. PLoS ONE 2(7), e610. https:\/\/doi.org\/10.1371\/journal.pone.0000610 (2007).","journal-title":"PLoS ONE"},{"issue":"17","key":"17770_CR89","doi-asserted-by":"publisher","first-page":"9294","DOI":"10.3390\/ijms22179294","volume":"22","author":"K Dopytalska","year":"2021","unstructured":"Dopytalska, K., Ciechanowicz, P., Wiszniewski, K., Szyma\u0144ska, E. & Walecka, I. The role of epigenetic factors in psoriasis. Int. J. Mol. Sci. 22(17), 9294. https:\/\/doi.org\/10.3390\/ijms22179294 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"17770_CR90","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.646796","volume":"8","author":"Y Xiuli","year":"2021","unstructured":"Xiuli, Y. & Honglin, W. MiRNAs flowing up and down: The concerto of psoriasis. Front. Med. 8, 646796. https:\/\/doi.org\/10.3389\/fmed.2021.646796 (2021).","journal-title":"Front. Med."},{"issue":"2","key":"17770_CR91","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/jid.2013.310","volume":"134","author":"S Noguchi","year":"2014","unstructured":"Noguchi, S. et al. MicroRNA-203 regulates melanosome transport and tyrosinase expression in melanoma cells by targeting kinesin superfamily protein 5b. J. Invest. Dermatol. 134(2), 461\u2013469. https:\/\/doi.org\/10.1038\/jid.2013.310 (2014).","journal-title":"J. Invest. Dermatol."},{"issue":"6","key":"17770_CR92","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.immuni.2010.05.009","volume":"32","author":"S Kuchen","year":"2010","unstructured":"Kuchen, S. et al. Regulation of MicroRNA expression and abundance during lymphopoiesis. Immunity 32(6), 828\u2013839. https:\/\/doi.org\/10.1016\/j.immuni.2010.05.009 (2010).","journal-title":"Immunity"},{"issue":"17","key":"17770_CR93","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1056\/NEJMoa050995","volume":"353","author":"GA Calin","year":"2005","unstructured":"Calin, G. A. et al. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N. Engl. J. Med. 353(17), 1793\u20131801. https:\/\/doi.org\/10.1056\/NEJMoa050995 (2005).","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"17770_CR94","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1158\/0008-5472.can-10-2488","volume":"71","author":"A Carracedo","year":"2011","unstructured":"Carracedo, A., Alimonti, A. & Pandolfi, P. P. PTEN level in tumor suppression: How much is too little?. Can. Res. 71(3), 629\u2013633. https:\/\/doi.org\/10.1158\/0008-5472.can-10-2488 (2011).","journal-title":"Can. Res."},{"issue":"7","key":"17770_CR95","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1158\/0008-5472.CAN-11-2663","volume":"72","author":"KB Jones","year":"2012","unstructured":"Jones, K. B. et al. miRNA signatures associate with pathogenesis and progression of osteosarcoma. Can. Res. 72(7), 1865\u20131877. https:\/\/doi.org\/10.1158\/0008-5472.CAN-11-2663 (2012).","journal-title":"Can. Res."},{"key":"17770_CR96","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1101\/sqb.2013.78.020024","volume":"78","author":"A Williams","year":"2013","unstructured":"Williams, A., Henao-Mejia, J., Harman, C. C. D. & Flavell, R. A. miR-181 and metabolic regulation in the immune system. Cold Spring Harb. Symp. Quant. Biol. 78, 223\u2013230. https:\/\/doi.org\/10.1101\/sqb.2013.78.020024 (2013).","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"17770_CR97","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1002\/eji.201747132","volume":"47","author":"M Friedrich","year":"2017","unstructured":"Friedrich, M. et al. The role of the miR-148\/-152 family in physiology and disease. Eur. J. Immunol. 47, 2026\u20132038. https:\/\/doi.org\/10.1002\/eji.201747132 (2017).","journal-title":"Eur. J. Immunol."},{"issue":"6","key":"17770_CR98","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1007\/s10753-018-0859-7","volume":"41","author":"Y Wang","year":"2018","unstructured":"Wang, Y., Yu, X., Wang, L., Ma, W. & Sun, Q. MiR-320b is down-regulated in psoriasis and modulates keratinocyte proliferation by targeting AKT3. Inflammation 41(6), 2160\u20132170. https:\/\/doi.org\/10.1007\/s10753-018-0859-7 (2018).","journal-title":"Inflammation"},{"issue":"2","key":"17770_CR99","doi-asserted-by":"publisher","first-page":"402","DOI":"10.7150\/ijbs.53419","volume":"17","author":"H Du","year":"2021","unstructured":"Du, H., Zhao, Y., Yin, Z., Wang, D. W. & Chen, C. The role of miR-320 in glucose and lipid metabolism disorder-associated diseases. Int. J. Biol. Sci. 17(2), 402\u2013416. https:\/\/doi.org\/10.7150\/ijbs.53419 (2021).","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"17770_CR100","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s11626-016-0093-2","volume":"53","author":"K Hu","year":"2017","unstructured":"Hu, K. & Liang, M. Upregulated microRNA-224 promotes ovarian cancer cell proliferation by targeting KLLN. In Vitro Cell. Dev. Biol. Anim. 53(2), 149\u2013156. https:\/\/doi.org\/10.1007\/s11626-016-0093-2 (2017).","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"issue":"9","key":"17770_CR101","doi-asserted-by":"publisher","first-page":"e0162378","DOI":"10.1371\/journal.pone.0162378","volume":"11","author":"Y Huang","year":"2016","unstructured":"Huang, Y. et al. Over-expressed miR-224 promotes the progression of cervical cancer via targeting RASSF8. PLoS ONE 11(9), e0162378. https:\/\/doi.org\/10.1371\/journal.pone.0162378 (2016).","journal-title":"PLoS ONE"},{"issue":"31","key":"17770_CR102","doi-asserted-by":"publisher","first-page":"49130","DOI":"10.18632\/oncotarget.9734","volume":"7","author":"F Liu","year":"2016","unstructured":"Liu, F., Liu, Y., Shen, J., Zhang, G. & Han, J. MicroRNA-224 inhibits proliferation and migration of breast cancer cells by down-regulating Fizzled 5 expression. Oncotarget 7(31), 49130\u201349142. https:\/\/doi.org\/10.18632\/oncotarget.9734 (2016).","journal-title":"Oncotarget"},{"issue":"26","key":"17770_CR103","doi-asserted-by":"publisher","first-page":"21802","DOI":"10.18632\/oncotarget.5224","volume":"6","author":"R Cui","year":"2015","unstructured":"Cui, R. et al. MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7. Oncotarget 6(26), 21802\u201321815. https:\/\/doi.org\/10.18632\/oncotarget.5224 (2015).","journal-title":"Oncotarget"},{"issue":"2","key":"17770_CR104","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.humpath.2014.10.027","volume":"46","author":"Y Wan","year":"2015","unstructured":"Wan, Y. et al. Dysregulated microRNA-224\/apelin axis associated with aggressive progression and poor prognosis in patients with prostate cancer. Hum. Pathol. 46(2), 295\u2013303. https:\/\/doi.org\/10.1016\/j.humpath.2014.10.027 (2015).","journal-title":"Hum. Pathol."},{"issue":"4","key":"17770_CR105","first-page":"680","volume":"31","author":"LA Rashed","year":"2021","unstructured":"Rashed, L. A. & Ibrahim, H. A. Expression of MicroRNA-224-3p in vitiligo. J. Pak. Assoc. Dermatol. 31(4), 680\u2013684 (2021).","journal-title":"J. Pak. Assoc. Dermatol."},{"issue":"6","key":"17770_CR106","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1111\/bjd.15681","volume":"177","author":"MS Mansuri","year":"2017","unstructured":"Mansuri, M. S. et al. The catalase gene promoter and 5\u02b9-untranslated region variants lead to altered gene expression and enzyme activity in vitiligo. Br. J. Dermatol. 177(6), 1590\u20131600. https:\/\/doi.org\/10.1111\/bjd.15681 (2017).","journal-title":"Br. J. Dermatol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-17770-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-17770-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-17770-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T05:40:50Z","timestamp":1669354850000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-17770-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,8]]},"references-count":106,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["17770"],"URL":"https:\/\/doi.org\/10.1038\/s41598-022-17770-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,8]]},"assertion":[{"value":"5 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"13526"}}