{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:22:18Z","timestamp":1791638538793,"version":"4.3.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The objective of this study was to retrospectively evaluate preoperative imaging modalities for localization of parathyroid adenomas with a view to enable minimally invasive parathyroidectomy and in particular, to consider the contribution of\n                    <jats:sup>18<\/jats:sup>\n                    F-fluorocholine-PET\/CT. 104 patients with primary hyperparathyroidism, who underwent parathyroid surgery in a single centre during a 6-year period were included. Of these, 103 underwent ultrasound, 97\n                    <jats:sup>99m<\/jats:sup>\n                    Tc-Pertechnetate\/SestaMIBI-SPECT, 20 MRI and 30\n                    <jats:sup>18<\/jats:sup>\n                    F-fluorocholine-PET\/CT. Based on surgical findings, sensitivities and specificities for correct lateralisation in orthotopic locations were: for ultrasound 0.75 (0.65\u20130.83) and 0.89 (0.81\u20130.94), for\n                    <jats:sup>99m<\/jats:sup>\n                    Tc-MIBI-SPECT 0.57 (0.46\u20130.67) and 0.97 (0.91\u20130.99), for MRI 0.60 (0.36\u20130.81) and 0.83 (0.59\u20130.96) and for\n                    <jats:sup>18<\/jats:sup>\n                    F-fluorocholine-PET\/CT 0.90 (0.73\u20130.98) and 0.90 (0.73\u20130.98). Correctly lateralized adenomas were significantly larger than those not found with ultrasound (p\u2009=\u20090.03) and SPECT (p\u2009=\u20090.002). Pre-operative PTH-levels were higher in single adenomas detected by scintigraphy than in those not (p\u2009=\u20090.02). 64 patients could be treated with a minimally invasive procedure. Cure after parathyroidectomy was obtained in 94% of patients.\n                    <jats:sup>18<\/jats:sup>\n                    F-Fluorocholine-PET\/CT could be shown to be a highly accurate modality to localize parathyroid adenomas preoperatively, obviating the need for total exploration in the majority of patients in whom ultrasound and scintigraphic results are discordant or both negative.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-18219-3","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T06:02:54Z","timestamp":1666159374000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Retrospective real-life study on preoperative imaging for minimally invasive parathyroidectomy in primary hyperparathyroidism"],"prefix":"10.1038","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3354-2944","authenticated-orcid":false,"given":"Jacqueline","family":"Bijnens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0529-7256","authenticated-orcid":false,"given":"Annick","family":"Van den Bruel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1341-829X","authenticated-orcid":false,"given":"Vincent","family":"Vander Poorten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7432-4452","authenticated-orcid":false,"given":"Ingeborg","family":"Goethals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7340-6402","authenticated-orcid":false,"given":"Steven","family":"Van Schandevyl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4052-1789","authenticated-orcid":false,"given":"Catherine","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4505-1237","authenticated-orcid":false,"given":"Frank","family":"De Geeter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"18219_CR1","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1210\/jc.2012-4022","volume":"98","author":"MW Yeh","year":"2013","unstructured":"Yeh, M. 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