{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:28:16Z","timestamp":1757543296639},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We assessed the influence of systemic lidocaine administration on ventilatory and circulatory parameters, and the pneumoperitoneum impact on the cardiopulmonary system during a laparoscopic appendectomy in children. A single-center parallel single-masked randomized controlled study was carried out with 58 patients (3\u201317\u00a0years). Intravenous lidocaine bolus of 1.5\u00a0mg\/kg over 5\u00a0min before induction of anesthesia followed by lidocaine infusion at 1.5\u00a0mg\/kg\/h intraoperatively. Respiratory system compliance (C, C\/kg), P<jats:sub>peak<\/jats:sub>-PEEP and Pulse rate (Pulse), systolic, diastolic and mean blood pressure (NBP<jats:sub>s<\/jats:sub>, NBP<jats:sub>d<\/jats:sub>, NBP<jats:sub>m<\/jats:sub>), assessed in the Lidocaine and Control group, at the: beginning (P<jats:sub>1<\/jats:sub>), minimum lung compliance (P<jats:sub>2<\/jats:sub>) and at the end of surgery (P<jats:sub>3<\/jats:sub>) were compared. The respiratory\/hemodynamic parameters did not differ between the groups at any stage of operation. Blood Pressure and P<jats:sub>peak<\/jats:sub>-PEEP were significantly higher at the P<jats:sub>2<\/jats:sub> compared to P<jats:sub>1<\/jats:sub> and P<jats:sub>3<\/jats:sub> stages (P\u2009&lt;\u20090.001, 1 \u2212 \u03b2\u2009\u2265\u20090.895) that correlated with lung compliance changes: C\/kg vs. NBP<jats:sub>s<\/jats:sub> and P<jats:sub>peak<\/jats:sub>-PEEP (\u2212\u00a00.42, \u2212\u00a00.84; P\u2009&lt;\u20090.001); C vs. Pulse and P<jats:sub>peak<\/jats:sub>-PEEP (\u2212\u00a00.48, \u2212\u00a00.46; P\u2009&lt;\u20090.001). Although an increase in intraabdominal pressure up to 12(15) mmHg causes significant changes in hemodynamic\/respiratory parameters, there appears to be no risk of fatal reactions in 1E, 2E ASA patients. Systemic lidocaine administration doesn\u2019t alleviate circulatory\/respiratory alterations during pneumoperitoneum. No lidocaine related episode of anaphylaxis, systemic toxicity, circulatory disturbances or neurological impairment occurred.<\/jats:p><jats:p><jats:bold>ClinicalTrials.gov<\/jats:bold>: 22\/03\/2019.<\/jats:p><jats:p><jats:bold>Trial registration number<\/jats:bold>: NCT03886896.<\/jats:p>","DOI":"10.1038\/s41598-022-18243-3","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T09:03:04Z","timestamp":1660813384000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of lidocaine on hemodynamic and respiratory parameters during laparoscopic appendectomy in children"],"prefix":"10.1038","volume":"12","clinical-trial-number":[{"clinical-trial-number":"nct03886896","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Maciej","family":"Kaszy\u0144ski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Stankiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof Jakub","family":"Pa\u0142ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Darowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"P\u0105gowska-Klimek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"18243_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12871-020-01218-0","volume":"21","author":"M Kaszy\u0144ski","year":"2021","unstructured":"Kaszy\u0144ski, M., Lewandowska, D., Sawicki, P., Wojcieszak, P. & P\u0105gowska-Klimek, I. Efficacy of intravenous lidocaine infusions for pain relief in children undergoing laparoscopic appendectomy: A randomized controlled trial. BMC Anesthesiol. 21, 2. https:\/\/doi.org\/10.1186\/s12871-020-01218-0 (2021).","journal-title":"BMC Anesthesiol."},{"key":"18243_CR2","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1097\/ALN.0000000000001527","volume":"126","author":"LK Dunn","year":"2017","unstructured":"Dunn, L. K. & Durieux, M. E. Perioperative use of intravenous lidocaine. Anesthesiology 126, 729\u2013737. https:\/\/doi.org\/10.1097\/ALN.0000000000001527 (2017).","journal-title":"Anesthesiology"},{"issue":"3","key":"18243_CR3","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.egja.2013.02.005","volume":"29","author":"A El-Deeb","year":"2013","unstructured":"El-Deeb, A., El-Morsy, G. Z., Ghanem, A. A. A., Elsharkawy, A. A. & Elmetwally, A. S. The effects of intravenous lidocaine infusion on hospital stay after major abdominal pediatric surgery. A randomized double-blinded study. Egypt. J. Anaesth. 29(3), 225\u2013230. https:\/\/doi.org\/10.1016\/j.egja.2013.02.005 (2013).","journal-title":"Egypt. J. Anaesth."},{"key":"18243_CR4","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12871-018-0545-1","volume":"18","author":"CP Both","year":"2018","unstructured":"Both, C. P. et al. Factors associated with intravenous lidocaine in pediatric patients undergoing laparoscopic appendectomy\u2014a retrospective, single-centre experience. BMC Anesthesiol. 18, 88. https:\/\/doi.org\/10.1186\/s12871-018-0545-1 (2018).","journal-title":"BMC Anesthesiol."},{"issue":"11","key":"18243_CR5","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.3390\/jcm8112014","volume":"8","author":"HM Lee","year":"2019","unstructured":"Lee, H. M., Choi, K. W., Byon, H. J., Lee, J. M. & Lee, J. R. Systemic lidocaine infusion for post-operative analgesia in children undergoing laparoscopic inguinal hernia repair: A randomized double-blind controlled trial. J. Clin. Med. 8(11), 2014 (2019).","journal-title":"J. Clin. Med."},{"key":"18243_CR6","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ijsu.2017.07.042","volume":"45","author":"X Song","year":"2017","unstructured":"Song, X., Sun, Y., Zhang, X., Li, T. & Yang, B. Effect of perioperative intravenous lidocaine infusion on postoperative recovery following laparoscopic cholecystectomy\u2014a randomized controlled trial. Int. J. Surg. 45, 8\u201313. https:\/\/doi.org\/10.1016\/j.ijsu.2017.07.042 (2017).","journal-title":"Int. J. Surg."},{"key":"18243_CR7","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/EJA.0000000000000807","volume":"35","author":"GC Echevarria","year":"2018","unstructured":"Echevarria, G. C. et al. 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