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Both maternal diabetes and obesity are linked to possible decreased fetal circulating DHA and increased placental DHA-lipids. Since myo-inositol is a promising intervention for gestational diabetes (GDM), we aimed to determine whether myo-inositol could rectify perturbations in placental DHA metabolism associated with maternal increasing glycemia and obesity and examine links with birthweight. Term placental villous explants from 17 women representing a range of BMIs and mid-gestational glycemia, were incubated with <jats:sup>13<\/jats:sup>C-labeled-DHA for 48\u00a0h, in 0.3\u00a0\u00b5mol\/L (control) or 60\u00a0\u00b5mol\/L myo-inositol. Individual newly synthesized <jats:sup>13<\/jats:sup>C-DHA-labeled lipid species were quantified by liquid-chromatography-mass-spectrometry. Compared with controls, incubation with myo-inositol decreased most <jats:sup>13<\/jats:sup>C-DHA-lipids in placental explants from women with higher BMI or higher glycemia, but increased <jats:sup>13<\/jats:sup>C-DHA-lipids with normal BMI or lower glycemia. Myo-inositol also increased <jats:sup>13<\/jats:sup>C-DHA-labeled lipids in cases of lower birthweight centile, but induced decreases at higher centiles. Myo-inositol therefore lowered DHA-lipids in placenta with high basal placental DHA-lipid production (higher BMI and glycemia) but increased DHA-lipids where basal processing capacity is low. Myo-inositol thus moderates placental DHA metabolism towards a physiological mean which may in turn moderate birthweight.<\/jats:p>","DOI":"10.1038\/s41598-022-18309-2","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T16:02:54Z","timestamp":1662048174000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Myo-inositol moderates maternal BMI and glycemia related variations in in-vitro placental 13C-DHA-metabolism, altering their relationships with birthweight"],"prefix":"10.1038","volume":"12","author":[{"given":"Oliver C.","family":"Watkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preben","family":"Selvam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshma Appukuttan","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria K. 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