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The main purpose of this study was to compare the modalities of delivery after the use of dinoprostone or misoprostol for labor induction in the preterm rupture of membranes after 35\u00a0weeks in women with an unfavorable cervix. We then studied maternal and fetal morbidity for the two drugs. Retrospective, single-center, comparative cohort study in a level 3 maternity unit in France from 2009 to 2018 comparing vaginal administration of misoprostol 50\u00a0\u00b5g every six hours (maximum 150\u00a0\u00b5g) and administration of dinoprostone 10\u00a0mg, a slow-release vaginal insert, for 24\u00a0h (maximum 20\u00a0mg), for labor induction in the preterm rupture of membranes after 35\u00a0weeks in women with an unfavorable cervix (Bishop score\u2009&lt;\u20096). We included 904 patients, 656 in the misoprostol group and 248 in the dinoprostone group. Vaginal delivery rate was significantly higher in the dinoprostone group (89% vs. 82%, <jats:italic>p<\/jats:italic>\u2009=\u20090.016). There were more cesarean sections for abnormal fetal heart rate in the misoprostol group (<jats:italic>p<\/jats:italic>\u2009=\u20090.005). The time interval from induction to the beginning of the active phase of labor and the duration of labor were shorter in the misoprostol group than in the dinoprostone group (437\u00a0min vs. 719\u00a0min, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and 335\u00a0min vs. 381\u00a0min, <jats:italic>p<\/jats:italic>\u2009=\u20090.0023, respectively). Maternal and neonatal outcomes were not significantly different in the two groups. Vaginal dinoprostone used for labor induction in preterm rupture of membranes seems to be more effective for vaginal delivery than vaginal misoprostol (50\u00a0\u00b5g).<\/jats:p>","DOI":"10.1038\/s41598-022-18948-5","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T15:02:53Z","timestamp":1662130973000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparative study of dinoprostone and misoprostol for induction of labor in patients with premature rupture of membranes after 35\u00a0weeks"],"prefix":"10.1038","volume":"12","author":[{"given":"Flavie","family":"Sire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Ponthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Eyraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Catalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Aubard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7558-0175","authenticated-orcid":false,"given":"Perrine","family":"Coste Mazeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"issue":"2","key":"18948_CR1","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1080\/01443615.2017.1329284","volume":"38","author":"L Pourali","year":"2018","unstructured":"Pourali, L. et al. 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