{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:18:41Z","timestamp":1792012721682,"version":"4.4.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Grant\u2212in\u2212Aid for Scientific Research","award":["JP16669931"],"award-info":[{"award-number":["JP16669931"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pancreatic ductal adenocarcinoma (PDAC) is a multifactorial disease, the molecular profile of which remains unclear. This study aimed at unveiling the disease-related protein networks associated with different outcomes of resectable, node-positive PDAC cases. We assessed laser-microdissected cancerous cells from PDAC tissues of a poor outcome group (POG; <jats:italic>n<\/jats:italic>\u2009=\u20094) and a better outcome group (BOG; <jats:italic>n<\/jats:italic>\u2009=\u20094). Noncancerous pancreatic duct tissues (<jats:italic>n<\/jats:italic>\u2009=\u20095) were used as the reference. We identified four representative network modules by applying a weighted network correlation analysis to the obtained quantitative PDAC proteome datasets. Two network modules that were significant for POG were associated with the heat shock response to hypoxia-related stress; in the latter, a large involvement of the non-canonical Hedgehog pathway (regulated by GLI1), the internal ribosome entry site-mediated cap-independent translation, the inositol requiring enzyme 1-alpha (IRE1\u03b1)\/X-box binding protein 1 pathway of the unfolding protein response (UPR), and the aerobic glycolysis was observed. By contrast, the BOG characteristic module was involved in the inactivation of the UPR pathway via the synoviolin 1-dependent proteasomal degradation of IRE1\u03b1, the activation of SOX2, and the loss of PALB2 (partner and localizer of BRCA2) function, all potentially suppressing malignant tumor development. Our findings might facilitate future therapeutic strategies for PDAC.<\/jats:p>","DOI":"10.1038\/s41598-022-19182-9","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T21:04:19Z","timestamp":1661807059000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Disease-related protein co-expression networks are associated with the prognosis of resectable node-positive pancreatic ductal adenocarcinoma"],"prefix":"10.1038","volume":"12","author":[{"given":"Toshihide","family":"Nishimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuyuki","family":"Takadate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimpei","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Minowa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Bando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Unno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"19182_CR1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung, H. et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209\u2013249 (2021).","journal-title":"CA Cancer J. Clin."},{"key":"19182_CR2","doi-asserted-by":"publisher","first-page":"32","DOI":"10.21037\/dmr-21-21","volume":"4","author":"AG Thomas","year":"2021","unstructured":"Thomas, A. G. & Awasthi, N. Targeted therapy for pancreatic cancer: Lessons learned and future opportunities. Dig. Med. Res. 4, 32 (2021).","journal-title":"Dig. Med. Res."},{"key":"19182_CR3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14740\/wjon1166","volume":"10","author":"P Rawla","year":"2019","unstructured":"Rawla, P., Sunkara, T. & Gaduputi, V. Epidemiology of pancreatic cancer: Global trends, etiology and risk factors. World J. Oncol. 10, 10\u201327 (2019).","journal-title":"World J. Oncol."},{"key":"19182_CR4","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-017249","volume":"8","author":"J Lee","year":"2018","unstructured":"Lee, J. et al. Management of recurrent pancreatic cancer after surgical resection: A protocol for systematic review, evidence mapping, and meta-analysis. BMJ Open 8, e017249 (2018).","journal-title":"BMJ Open"},{"key":"19182_CR5","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/00006676-200404000-00002","volume":"28","author":"S Matsuno","year":"2004","unstructured":"Matsuno, S. et al. Pancreatic Cancer Registry in Japan: 20 years of experience. Pancreas 28, 219\u2013230 (2004).","journal-title":"Pancreas"},{"key":"19182_CR6","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1007\/s11605-010-1213-z","volume":"14","author":"R Kim","year":"2010","unstructured":"Kim, R. et al. A single institution review of adjuvant therapy outcomes for resectable pancreatic adenocarcinoma: Outcome and prognostic indicators. J. Gastrointest. Surg. 14, 1159\u20131169 (2010).","journal-title":"J. Gastrointest. Surg."},{"key":"19182_CR7","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/00000658-200301000-00011","volume":"237","author":"JE Lim","year":"2003","unstructured":"Lim, J. E., Chien, M. W. & Earle, C. C. Prognostic factors following curative resection for pancreatic adenocarcinoma: A population-based, linked database analysis of 396 patients. Ann. Surg. 237, 74\u201385 (2003).","journal-title":"Ann. Surg."},{"key":"19182_CR8","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1080\/14789450.2019.1654861","volume":"16","author":"T Nishimura","year":"2019","unstructured":"Nishimura, T. et al. Current status of clinical proteogenomics in lung cancer. Expert Rev. Proteom. 16, 761\u2013772 (2019).","journal-title":"Expert Rev. Proteom."},{"key":"19182_CR9","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder, P. & Horvath, S. WGCNA: An R package for weighted correlation network analysis. BMC Bioinform. 9, 559 (2008).","journal-title":"BMC Bioinform."},{"key":"19182_CR10","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1038\/s41598-021-81509-9","volume":"11","author":"K Yamada","year":"2021","unstructured":"Yamada, K. et al. Protein co-expression networks identified from HOT lesions of ER+HER2-Ki-67high luminal breast carcinomas. Sci. Rep. 11, 1705 (2021).","journal-title":"Sci. Rep."},{"key":"19182_CR11","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/000102067","volume":"24","author":"K Hirata","year":"2007","unstructured":"Hirata, K. et al. Current status of surgery for pancreatic cancer. Dig. Surg. 24, 137\u2013147 (2007).","journal-title":"Dig. Surg."},{"key":"19182_CR12","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk, D. et al. STRING v11: Protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47, D607\u2013D613 (2019).","journal-title":"Nucleic Acids Res."},{"key":"19182_CR13","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon, P. et al. Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498\u20132504 (2003).","journal-title":"Genome Res."},{"issue":"Suppl 4","key":"19182_CR14","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","volume":"8","author":"CH Chin","year":"2014","unstructured":"Chin, C. H. et al. cytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Syst. Biol. 8(Suppl 4), S11 (2014).","journal-title":"BMC Syst. Biol."},{"key":"19182_CR15","doi-asserted-by":"publisher","first-page":"4767","DOI":"10.1073\/pnas.1720588115","volume":"115","author":"K Tamura","year":"2018","unstructured":"Tamura, K. et al. Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer. Proc. Natl. Acad. Sci. USA 115, 4767\u20134772 (2018).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"19182_CR16","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.tranon.2018.03.005","volume":"11","author":"Y Song","year":"2018","unstructured":"Song, Y. et al. Label-free quantitative proteomics unravels carboxypeptidases as the novel biomarker in pancreatic ductal adenocarcinoma. Transl. Oncol. 11, 691\u2013699 (2018).","journal-title":"Transl. Oncol."},{"key":"19182_CR17","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s00535-017-1388-0","volume":"53","author":"A Masamune","year":"2018","unstructured":"Masamune, A. et al. Nationwide survey of hereditary pancreatitis in Japan. J. Gastroenterol. 53, 152\u2013160 (2018).","journal-title":"J. Gastroenterol."},{"key":"19182_CR18","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2119\/molmed.2013.00102","volume":"20","author":"Z Zhang","year":"2014","unstructured":"Zhang, Z. et al. Underexpressed CNDP2 participates in gastric cancer growth inhibition through activating the MAPK signaling pathway. Mol. Med. 20, 17\u201328 (2014).","journal-title":"Mol. Med."},{"key":"19182_CR19","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12957-017-1111-x","volume":"15","author":"HQ Xi","year":"2017","unstructured":"Xi, H. Q. et al. Expression and clinicopathologic significance of TUFM and p53 for the normal\u2013adenoma\u2013carcinoma sequence in colorectal epithelia. World J. Surg. Oncol. 15, 90 (2017).","journal-title":"World J. Surg. Oncol."},{"key":"19182_CR20","doi-asserted-by":"publisher","first-page":"58470","DOI":"10.18632\/oncotarget.11298","volume":"7","author":"Y Song","year":"2016","unstructured":"Song, Y. et al. Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma. Oncotarget 7, 58470\u201358482 (2016).","journal-title":"Oncotarget"},{"key":"19182_CR21","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.gene.2015.06.018","volume":"570","author":"AD Zuehlke","year":"2015","unstructured":"Zuehlke, A. D., Beebe, K., Neckers, L. & Prince, T. Regulation and function of the human HSP90AA1 gene. Gene 570, 8\u201316 (2015).","journal-title":"Gene"},{"key":"19182_CR22","first-page":"2280","volume":"9","author":"Y He","year":"2019","unstructured":"He, Y. et al. PGK1-mediated cancer progression and drug resistance. Am. J. Cancer Res. 9, 2280\u20132302 (2019).","journal-title":"Am. J. Cancer Res."},{"key":"19182_CR23","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41389-021-00306-1","volume":"10","author":"YG Lee","year":"2021","unstructured":"Lee, Y. G. et al. LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival. Oncogenesis 10, 18 (2021).","journal-title":"Oncogenesis"},{"key":"19182_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.112153","volume":"394","author":"M Li","year":"2020","unstructured":"Li, M. et al. Microenvironment remodeled by tumor and stromal cells elevates fibroblast-derived COL1A1 and facilitates ovarian cancer metastasis. Exp. Cell Res. 394, 112153 (2020).","journal-title":"Exp. Cell Res."},{"key":"19182_CR25","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.canlet.2018.01.057","volume":"419","author":"D Chakravarthy","year":"2018","unstructured":"Chakravarthy, D. et al. Palmatine suppresses glutamine-mediated interaction between pancreatic cancer and stellate cells through simultaneous inhibition of survivin and COL1A1. Cancer Lett. 419, 103\u2013115 (2018).","journal-title":"Cancer Lett."},{"key":"19182_CR26","doi-asserted-by":"publisher","first-page":"635","DOI":"10.3389\/fonc.2019.00635","volume":"9","author":"IS Mohiuddin","year":"2019","unstructured":"Mohiuddin, I. S. & Kang, M. H. DNA-PK as an emerging therapeutic target in cancer. Front. Oncol. 9, 635 (2019).","journal-title":"Front. Oncol."},{"key":"19182_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191377","volume":"13","author":"MK Hassan","year":"2018","unstructured":"Hassan, M. K., Kumar, D., Naik, M. & Dixit, M. The expression profile and prognostic significance of eukaryotic translation elongation factors in different cancers. PLoS ONE 13, e0191377 (2018).","journal-title":"PLoS ONE"},{"key":"19182_CR28","doi-asserted-by":"publisher","first-page":"112074","DOI":"10.1016\/j.biopha.2021.112074","volume":"142","author":"S Yang","year":"2021","unstructured":"Yang, S., Haiyan, X. H. & Cao, L. Recent advances in heat shock proteins in cancer diagnosis, prognosis, metabolism and treatment. Biomed. Pharmacother. 142, 112074 (2021).","journal-title":"Biomed. Pharmacother."},{"key":"19182_CR29","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1093\/abbs\/gmy085","volume":"50","author":"P Zhang","year":"2018","unstructured":"Zhang, P. et al. Oncogenic heterogeneous nuclear ribonucleoprotein D-like promotes the growth of human colon cancer SW620 cells via its regulation of cell-cycle. Acta Biochim. Biophys. Sin. 50, 880\u2013887 (2018).","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"19182_CR30","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.7150\/thno.53102","volume":"11","author":"Y Li","year":"2021","unstructured":"Li, Y. et al. Silencing PCBP2 normalizes desmoplastic stroma and improves the antitumor activity of chemotherapy in pancreatic cancer. Theranostics 11, 2182\u20132200 (2021).","journal-title":"Theranostics"},{"key":"19182_CR31","doi-asserted-by":"publisher","first-page":"2790","DOI":"10.1038\/onc.2014.190","volume":"34","author":"HH Chen","year":"2015","unstructured":"Chen, H. H., Yu, H. I., Cho, W. C. & Tarn, W. Y. DDX3 modulates cell adhesion and motility and cancer cell metastasis via Rac1-mediated signaling pathway. Oncogene 34, 2790\u20132800 (2015).","journal-title":"Oncogene"},{"key":"19182_CR32","doi-asserted-by":"publisher","first-page":"22687","DOI":"10.18632\/oncotarget.8143","volume":"7","author":"DW Wu","year":"2016","unstructured":"Wu, D. W. et al. DDX3 enhances oncogenic KRAS-induced tumor invasion in colorectal cancer via the \u03b2-catenin\/ZEB1 axis. Oncotarget 7, 22687\u201322699 (2016).","journal-title":"Oncotarget"},{"key":"19182_CR33","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","volume":"30","author":"A Kr\u00e4mer","year":"2014","unstructured":"Kr\u00e4mer, A., Green, J., Pollard, J. Jr. & Tugendreich, S. IPA: Causal analysis approaches in ingenuity pathway analysis. Bioinformatics 30, 523\u2013530 (2014).","journal-title":"Bioinformatics"},{"key":"19182_CR34","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12935-020-1135-0","volume":"20","author":"F Jiao","year":"2020","unstructured":"Jiao, F. et al. Caveolin-2 is regulated by BRD4 and contributes to cell growth in pancreatic cancer. Cancer Cell Int. 20, 55 (2020).","journal-title":"Cancer Cell Int."},{"key":"19182_CR35","doi-asserted-by":"publisher","first-page":"110872","DOI":"10.1016\/j.biopha.2020.110872","volume":"132","author":"TT Li","year":"2020","unstructured":"Li, T. T. & Zhu, H. B. LKB1 and cancer: The dual role of metabolic regulation. Biomed. Pharmacother. 132, 110872 (2020).","journal-title":"Biomed. Pharmacother."},{"key":"19182_CR36","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.cytogfr.2012.01.003","volume":"23","author":"C Huang","year":"2012","unstructured":"Huang, C. & Xie, K. Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis. Cytokine Growth Factor Rev. 23, 25\u201335 (2012).","journal-title":"Cytokine Growth Factor Rev."},{"key":"19182_CR37","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1111\/pin.12476","volume":"66","author":"K Kasai","year":"2016","unstructured":"Kasai, K. GLI1, a master regulator of the hallmark of pancreatic cancer. Pathol. Int. 66, 653\u2013660 (2016).","journal-title":"Pathol. Int."},{"key":"19182_CR38","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/nrc2824","volume":"10","author":"D Silvera","year":"2010","unstructured":"Silvera, D., Formenti, S. C. & Schneider, R. J. Translational control in cancer. Nat. Rev. Cancer 10, 254\u2013266 (2010).","journal-title":"Nat. Rev. Cancer"},{"key":"19182_CR39","doi-asserted-by":"publisher","first-page":"6228","DOI":"10.3390\/ijms22126228","volume":"22","author":"A Cormio","year":"2021","unstructured":"Cormio, A., Sanguedolce, F., Pesce, V. & Musicco, C. Mitochondrial caseinolytic protease P: A possible novel prognostic marker and therapeutic target in cancer. Int. J. Mol. Sci. 22, 6228 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"19182_CR40","doi-asserted-by":"publisher","first-page":"930","DOI":"10.3390\/ijms23020930","volume":"23","author":"BD Yun","year":"2022","unstructured":"Yun, B. D. et al. Oncogenic role of exosomal circular and long noncoding RNAs in gastrointestinal cancers. Int. J. Mol. Sci. 23, 930 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"19182_CR41","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/s42003-019-0343-4","volume":"2","author":"TJ Chen","year":"2019","unstructured":"Chen, T. J. et al. Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation. Commun. Biol. 2, 105 (2019).","journal-title":"Commun. Biol."},{"key":"19182_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110069","volume":"127","author":"S Chen","year":"2020","unstructured":"Chen, S. et al. The emerging role of XBP1 in cancer. Biomed. Pharmacother. 127, 110069 (2020).","journal-title":"Biomed. Pharmacother."},{"key":"19182_CR43","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3390\/cancers13020261","volume":"13","author":"CM Robinson","year":"2021","unstructured":"Robinson, C. M. et al. An emerging role for the unfolded protein response in pancreatic cancer. Cancers (Basel) 13, 261 (2021).","journal-title":"Cancers (Basel)"},{"key":"19182_CR44","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1158\/2159-8290.CD-17-1033","volume":"8","author":"L Chen","year":"2018","unstructured":"Chen, L. et al. CD38-mediated immunosuppression as a mechanism of tumor cell escape from PD-1\/PD-L1 blockade. Cancer Discov. 8, 1156\u20131175 (2018).","journal-title":"Cancer Discov."},{"key":"19182_CR45","doi-asserted-by":"publisher","first-page":"6630295","DOI":"10.1155\/2021\/6630295","volume":"2021","author":"S Dwivedi","year":"2021","unstructured":"Dwivedi, S., Rend\u00f3n-Huerta, E. P., Ortiz-Navarrete, V. & Monta\u00f1o, L. F. CD38 and regulation of the immune response cells in cancer. J. Oncol. 2021, 6630295 (2021).","journal-title":"J. Oncol."},{"key":"19182_CR46","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201948780","volume":"21","author":"A Steins","year":"2020","unstructured":"Steins, A. et al. High-grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF-1. EMBO Rep. 21, e48780 (2020).","journal-title":"EMBO Rep."},{"key":"19182_CR47","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/labinvest.2014.53","volume":"94","author":"K Yamazaki","year":"2014","unstructured":"Yamazaki, K. et al. Upregulated SMAD3 promotes epithelial-mesenchymal transition and predicts poor prognosis in pancreatic ductal adenocarcinoma. Lab. Invest. 94, 683\u2013691 (2014).","journal-title":"Lab. Invest."},{"key":"19182_CR48","doi-asserted-by":"publisher","first-page":"19990","DOI":"10.18632\/oncotarget.4598","volume":"6","author":"T Namba","year":"2015","unstructured":"Namba, T. et al. Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1\u03b1\/XBP1 pathway. Oncotarget 6, 19990\u201320001 (2015).","journal-title":"Oncotarget"},{"key":"19182_CR49","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1083\/jcb.201312042","volume":"204","author":"A Ruggiano","year":"2014","unstructured":"Ruggiano, A., Foresti, O. & Carvalho, P. Quality control: ER-associated degradation: Protein quality control and beyond. J. Cell Biol. 204, 869\u2013879 (2014).","journal-title":"J. Cell Biol."},{"key":"19182_CR50","doi-asserted-by":"publisher","first-page":"5031","DOI":"10.1016\/j.cell.2021.08.023","volume":"184","author":"L Cao","year":"2021","unstructured":"Cao, L. et al. Proteogenomic characterization of pancreatic ductal adenocarcinoma. Cell 184, 5031\u20135052 (2021).","journal-title":"Cell"},{"key":"19182_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140253","volume":"10","author":"JD Weyandt","year":"2015","unstructured":"Weyandt, J. D. et al. Wild-type Hras suppresses the earliest stages of tumorigenesis in a genetically engineered mouse model of pancreatic cancer. PLoS ONE 10, e0140253 (2015).","journal-title":"PLoS ONE"},{"key":"19182_CR52","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.yexcr.2018.07.041","volume":"371","author":"B Yan","year":"2018","unstructured":"Yan, B. et al. Paracrine HGF\/c-MET enhances the stem cell-like potential and glycolysis of pancreatic cancer cells via activation of YAP\/HIF-1\u03b1. Exp. Cell Res. 371, 63\u201371 (2018).","journal-title":"Exp. Cell Res."},{"key":"19182_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118523","volume":"263","author":"J Xu","year":"2020","unstructured":"Xu, J., Liu, S., Yang, X., Cao, S. & Zhou, Y. Paracrine HGF promotes EMT and mediates the effects of PSC on chemoresistance by activating c-Met\/PI3K\/Akt signaling in pancreatic cancer in vitro. Life Sci. 263, 118523 (2020).","journal-title":"Life Sci."},{"key":"19182_CR54","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1093\/jmcb\/mjy080","volume":"12","author":"MA Mamun","year":"2020","unstructured":"Mamun, M. A., Mannoor, K., Cao, J., Qadri, F. & Song, X. SOX2 in cancer stemness: Tumor malignancy and therapeutic potentials. J. Mol. Cell Biol. 12, 85\u201398 (2020).","journal-title":"J. Mol. Cell Biol."},{"key":"19182_CR55","doi-asserted-by":"publisher","first-page":"34890","DOI":"10.18632\/oncotarget.8994","volume":"7","author":"EL Wuebben","year":"2016","unstructured":"Wuebben, E. L. et al. SOX2 functions as a molecular rheostat to control the growth, tumorigenicity and drug responses of pancreatic ductal adenocarcinoma cells. Oncotarget 7, 34890\u201334906 (2016).","journal-title":"Oncotarget"},{"key":"19182_CR56","doi-asserted-by":"publisher","first-page":"5842","DOI":"10.18632\/oncotarget.4683","volume":"6","author":"S H\u00fcnten","year":"2015","unstructured":"H\u00fcnten, S. & Hermeking, H. p53 directly activates cystatin D\/CST5 to mediate mesenchymal-epithelial transition: A possible link to tumor suppression by vitamin D3. Oncotarget 6, 5842\u201315856 (2015).","journal-title":"Oncotarget"},{"key":"19182_CR57","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1126\/science.1171202","volume":"324","author":"S Jones","year":"2009","unstructured":"Jones, S. et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science 324, 217 (2009).","journal-title":"Science"},{"key":"19182_CR58","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3892\/ol.2021.12485","volume":"21","author":"O Ge","year":"2021","unstructured":"Ge, O. et al. PALB2 upregulation is associated with a poor prognosis in pancreatic ductal adenocarcinoma. Oncol. Lett. 21, 224 (2021).","journal-title":"Oncol. Lett."},{"key":"19182_CR59","doi-asserted-by":"publisher","DOI":"10.2196\/27633","volume":"23","author":"A L\u00e1nczky","year":"2021","unstructured":"L\u00e1nczky, A. & Gy\u0151rffy, B. Web-based survival analysis tool tailored for medical research (KMplot): Development and implementation. J. Med. Internet Res. 23, e27633 (2021).","journal-title":"J. Med. Internet Res."},{"key":"19182_CR60","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1158\/1535-7163.MCT-10-0893","volume":"10","author":"MC Villarroel","year":"2011","unstructured":"Villarroel, M. C. et al. Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer. Mol. Cancer Ther. 10, 3\u20138 (2011).","journal-title":"Mol. Cancer Ther."},{"key":"19182_CR61","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3389\/fonc.2020.00301","volume":"10","author":"S Wu","year":"2020","unstructured":"Wu, S. et al. Molecular mechanisms of PALB2 function and its role in breast cancer management. Front. Oncol. 10, 301 (2020).","journal-title":"Front. Oncol."},{"key":"19182_CR62","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.2144\/05386SU06","volume":"38","author":"DA Prieto","year":"2005","unstructured":"Prieto, D. A. et al. Liquid tissue: Proteomic profiling of formalin-fixed tissues. Biotechniques 38, S32\u2013S35 (2005).","journal-title":"Biotechniques"},{"key":"19182_CR63","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.1021\/pr900468k","volume":"8","author":"H Kawase","year":"2009","unstructured":"Kawase, H. et al. Differential LC-MS-based proteomics of surgical human cholangiocarcinoma tissues. J. Proteome Res. 8, 4092\u20134103 (2009).","journal-title":"J. Proteome Res."},{"key":"19182_CR64","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1002\/ijc.27797","volume":"132","author":"T Takadate","year":"2013","unstructured":"Takadate, T. et al. Novel prognostic protein markers of resectable pancreatic cancer identified by coupled shotgun and targeted proteomics using formalin-fixed paraffin-embedded tissues. Int. J. Cancer 132, 1368\u20131382 (2013).","journal-title":"Int. J. Cancer"},{"key":"19182_CR65","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s12859-017-1708-7","volume":"18","author":"A Khan","year":"2017","unstructured":"Khan, A. & Mathelier, A. Intervene: A tool for intersection and visualization of multiple gene or genomic region sets. BMC Bioinform. 18, 287 (2017).","journal-title":"BMC Bioinform."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-19182-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-19182-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-19182-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T22:03:09Z","timestamp":1661810589000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-19182-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["19182"],"URL":"https:\/\/doi.org\/10.1038\/s41598-022-19182-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,29]]},"assertion":[{"value":"9 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14709"}}