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The purpose of this study is to report and describe the clinical course and outcome of pediatric bacterial osteomyelitis in our experience. We reported the clinical, diagnostic, and treatment characteristics of all cases of osteomyelitis in children younger than 18\u00a0years of age who were hospitalized between January 2010 and December 2021 at the Bambino Ges\u00f9 Children\u2019s Hospital in Rome, Italy, we compared patients with and without complications at follow-up, to identify any predictive factor for sequelae. The study sample included 319 cases of pediatric bacterial osteomyelitis. The median age was 7.77\u00a0years. Males (60.8%) were more affected than females. The most affected bones were the femur, tibia, and spine. Etiology was identified in 40.1% of cases, with <jats:italic>S.aureus<\/jats:italic> as the most common causative agent. Sequelae were reported in 43 cases (13.5%). The main predictors of sequelae were sepsis on admission and hypergammaglobulinemia. 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Early recognition and aggressive treatment of this subgroup of patients may lead to a reduction in complications.\n<\/jats:p>","DOI":"10.1038\/s41598-022-19208-2","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T10:05:11Z","timestamp":1662026711000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Clinical report and predictors of sequelae of 319 cases of pediatric bacterial 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