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This study aimed to evaluate the preventive therapies for MRONJ. Following four cycles of zoledronic acid administration,\n                    <jats:italic>Wistar<\/jats:italic>\n                    rats had their molar extracted, and were organized into nine treatment groups: negative control group\u00a0(NCG), treated with saline solution and blood-clot in the alveolus; positive control group (PCG), with blood-clot in the alveolus; BG, \u03b2-tricalcium phosphate-based biomaterial; DG, 10% doxycycline gel; aG, antimicrobial photodynamic therapy; and DBG, aBG, aDG, and aDBG, using combination therapy. After 28\u00a0days, the lowest bone volume (BV\/TV) was reported in PCG (42.17%\u2009\u00b1\u20092.65), and the highest in aDBG (69.85%\u2009\u00b1\u20096.25) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The higher values of daily mineral apposition rate were recorded in aDBG (2.64\u2009\u00b1\u20090.48) and DBG (2.30\u2009\u00b1\u20090.37) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Moreover, aDBG presented with the highest neoformed bone area (82.44%\u2009\u00b1\u20092.69) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Non-vital bone was reported only in the PCG (37.94\u2009\u00b1\u200918.70%). Owing to the key role of the biomaterial, the combination approach (aDBG) was the most effective in preventing MRONJ following tooth extraction.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-20128-4","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T06:06:21Z","timestamp":1664777181000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw"],"prefix":"10.1038","volume":"12","author":[{"given":"Henrique","family":"Hadad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00eds","family":"Kawamata de Jesus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Fl\u00e1via","family":"Piquera Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Rinaldi Matheus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Gabriella","family":"de Souza Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier","family":"Paolo Poli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elcio","family":"Marcantonio Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Pozzi Semeghini Guastaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Maiorana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano","family":"Milanezi de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisley","family":"\u00c1vila Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"issue":"35","key":"20128_CR1","doi-asserted-by":"publisher","first-page":"3978","DOI":"10.1200\/JCO.2017.75.4614","volume":"35","author":"C Van Poznak","year":"2017","unstructured":"Van Poznak, C. et al. 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