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Growing evidence suggests increased blood pressure variability is linked to Alzheimer\u2019s disease pathophysiology indexed by cerebrospinal fluid and positron emission tomography markers, but relationships with plasma Alzheimer\u2019s disease markers have not been investigated. In this cross-sectional study of 54 community-dwelling older adults (aged 55\u201388, mean age 69.9 [8.2 SD]), elevated blood pressure variability over 5\u00a0min was associated with lower levels of plasma A\u03b2\n                    <jats:sub>1\u201342<\/jats:sub>\n                    (standardized \u00df\u2009=\u2009\u2009\u2212\u20090.36 [95% CI\u2009\u2212\u20090.61,\u2009\u2212\u20090.12];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005; adjusted\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.28) and A\u03b2\n                    <jats:sub>1\u201342<\/jats:sub>\n                    : A\u03b2\n                    <jats:sub>1\u201340<\/jats:sub>\n                    ratio (\u00df\u2009=\u2009\u2009\u2212\u20090.49 [95% CI\u2009\u2212\u20090.71,\u2009\u2212\u20090.22];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001; adjusted\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.28), and higher levels of total tau (\u00df\u2009=\u20090.27 [95% CI 0.01, 0.54];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04; adjusted\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.19) and Ptau\n                    <jats:sub>181<\/jats:sub>\n                    :A\u03b2\n                    <jats:sub>1\u201342<\/jats:sub>\n                    ratio (\u00df\u2009=\u20090.26 [95% CI 0.02, 0.51];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04; adjusted\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.22). Findings suggest higher blood pressure variability is linked to plasma biomarkers of increased Alzheimer\u2019s disease pathophysiology.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-20627-4","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T12:02:53Z","timestamp":1665662573000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Blood pressure variability and plasma Alzheimer\u2019s disease biomarkers in older adults"],"prefix":"10.1038","volume":"12","author":[{"given":"Isabel J.","family":"Sible","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Yew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Yun","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Paul M.","family":"Alitin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aim\u00e9e","family":"Gaubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubir","family":"Dutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Blanken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean K.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisa J.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunima","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemah","family":"Shenasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen E.","family":"Rodgers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia E.","family":"Sturm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Head","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Nation","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"20627_CR1","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/S1474-4422(19)30228-5","volume":"18","author":"CA Lane","year":"2019","unstructured":"Lane, C. 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