{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:44:39Z","timestamp":1792687479497,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We aimed to derive comprehensive MRI parameters that reflect intramuscular fat infiltration severity for designated lower extremity levels, based on semiquantitative analyses in Charcot-Marie-Tooth disease type 1A (CMT1A) patients. We reviewed lower extremity MRIs of 116 CMT1A patients. Intramuscular fat infiltration grading using the Mercuri scale was performed for the non-dominant lower extremity at three levels (proximal, mid, and distal) for the thigh and at two levels (proximal and distal) for the lower leg. Based on MRI results, the following parameters were calculated for each level and for entire muscles: fat infiltration proportion (FIP), significant fat infiltration proportion (SigFIP), and severe fat infiltration proportion (SevFIP). The relationships between the MRI parameters and clinical data were evaluated using Spearman\u2019s correlation analysis. FIP, SigFIP, and SevFIP measured for entire muscles significantly correlated with Charcot-Marie-Tooth Neuropathy Score (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), functional disability scale (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), 10-m walk test time (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0003, 0.0010, and 0.0011), and disease duration (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Similar correlations were demonstrated for FIP, SigFIP, and SevFIP acquired from the lower leg. Our MRI parameters obtained through semiquantitative analyses of muscles significantly correlated with clinical parameters in CMT1A patients, suggesting their potential applicability as imaging markers for clinical severity.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-21112-8","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T08:03:35Z","timestamp":1664957015000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Magnetic resonance imaging-based lower limb muscle evaluation in Charcot-Marie-Tooth disease type 1A patients and its correlation with clinical data"],"prefix":"10.1038","volume":"12","author":[{"given":"Yeo Jin","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Cheol","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Ok","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"key":"21112_CR1","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/S1474-4422(09)70110-3","volume":"8","author":"D Pareyson","year":"2009","unstructured":"Pareyson, D. & Marchesi, C. Diagnosis, natural history, and management of Charcot-Marie-Tooth disease. Lancet Neurol. 8, 654\u2013667. https:\/\/doi.org\/10.1016\/S1474-4422(09)70110-3 (2009).","journal-title":"Lancet Neurol."},{"key":"21112_CR2","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1212\/01.wnl.0000297553.36441.ce","volume":"70","author":"ME Shy","year":"2008","unstructured":"Shy, M. E. et al. Neuropathy progression in Charcot-Marie-Tooth disease type 1A. Neurology 70, 378\u2013383. https:\/\/doi.org\/10.1212\/01.wnl.0000297553.36441.ce (2008).","journal-title":"Neurology"},{"key":"21112_CR3","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1093\/brain\/awh693","volume":"129","author":"E Gallardo","year":"2006","unstructured":"Gallardo, E., Garcia, A., Combarros, O. & Berciano, J. Charcot-Marie-Tooth disease type 1A duplication: Spectrum of clinical and magnetic resonance imaging features in leg and foot muscles. 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