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Here, we introduce a hand-held soft robot that can be clenched by the wearer. The robot comprises small airbags that can be inflated to provide the wearer with a feeling of being clenched. We then conducted an in-depth study of 66 adults who participated in a pain research protocol using thermal stimulation to investigate the effect of wearing the robot on pain perception and fear of injections. Pain assessment scale scores for perceived pain decreased significantly<jats:inline-formula><jats:alternatives><jats:tex-math>$$(p &lt; 0.05)$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mo>(<\/mml:mo><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><mml:mo>)<\/mml:mo><\/mml:mrow><\/mml:math><\/jats:alternatives><\/jats:inline-formula>when participants wore the robot compared with the baseline condition in which the robot was not worn. In addition, the saliva test results showed a downward trend in oxytocin level when the robot provided the wearer with haptic feedback via the inflation of the internal airbags in response to the wearer\u2019s clench. Furthermore, the negative psychological state of participants, as measured using the positive and negative affect scale, improved significantly when wearing the robot. We also revealed that the salivary cortisol level, an indicator of stress, decreased significantly across all participants at the end of the experiment. In addition, participants\u2019 fear of injections was significantly improved after participation in the experiment. These results suggest that the wearable soft robot may alleviate the human perception of pain and fear in during medical treatments, such as vaccinations.<\/jats:p>","DOI":"10.1038\/s41598-022-21183-7","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T10:03:16Z","timestamp":1666000996000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A wearable soft robot that can alleviate the pain and fear of the wearer"],"prefix":"10.1038","volume":"12","author":[{"given":"Youchan","family":"Yim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihide","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"21183_CR1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.neubiorev.2008.09.011","volume":"34","author":"H Olausson","year":"2010","unstructured":"Olausson, H., Wessberg, J., McGlone, F. & Vallbo, \u00c5. 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