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However, most works on airway anatomy are tended to morphological description before anaesthesia. This study aimed to evaluate the changes of upper airway after anaesthesia induction and using pre-anesthetic ultrasound measurements to predict Difficult Laryngoscopy (DL). We included 104 eligible subjects with complete data, who were performed tracheal intubations under general anaesthesia in the study. The upper airway changes before and after anaesthesia induction were determined by seven neck ultrasound measurements, included as follow: (1) Distance from skin to under surface of Tongue (DT), (2) Thickness of the thickest part of Tongue body (TT), (3) Hyoid Mental Distance (HMD), (4) Depth of Hyoid (DH), (5) Width of Hyoid (WH), (6) Distance from Skin to Epiglottis (DSE), (7) Depth of the anterior combination of the Vocal Cords (DVC). DL was evaluated with Cormack\u2013Lehane (CL). Data regarding HMD [from 45.3 (42.4\u201348.5) to 41.1 (38.5\u201344.9) mm], DH [from 8.7 (6.6\u201310.9) to 7.0 (5.3\u20139.1) mm], DSE [from 20.1 (16.6\u201322.5) to 19.5 (16.5\u201321.6) mm] and the DVC [from 7.1 (5.7\u20138.3) to 6.8 (5.7\u20137.9) mm] were decreased (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05), while the DT [from 15.9 (13.1\u201318.4) to 17.4 (14.5\u201319.8) mm] was increased (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&gt;\u20090.05) after anaesthesia induction. Additionally, when cut-off value of DSE was 21.25\u00a0mm before anaesthesia, it may be better predicted to DL [sensitivity 80.0% (95% CI: 60.7\u201391.6%) and specificity 83.8% (95% CI: 73.0\u201391.0%)]. The upper airway after induction showed the propensity of collapsibility by ultrasound measurements. Compared with other indicators, the DSE assessed by ultrasound might be considered to a valuable predictor of DL.\n                  <\/jats:p>\n                  <jats:p>Trial registration: The study was registered in ClinicalTrials.gov on 23th Jan 2019, ChiCTR1900021123.<\/jats:p>","DOI":"10.1038\/s41598-022-21695-2","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T07:11:40Z","timestamp":1667459500000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Ultrasound measurements for evaluation of changes in upper airway during anaesthesia induction and prediction difficult laryngoscopy: a prospective observational study"],"prefix":"10.1038","volume":"12","clinical-trial-number":[{"clinical-trial-number":"chictr1900021123","registry":"10.18810\/chictr"}],"author":[{"given":"Xia","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Hua","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"issue":"19","key":"21695_CR1","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1056\/NEJMra1916801","volume":"384","author":"T Heidegger","year":"2021","unstructured":"Heidegger, T. 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