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GA has shown promise in protection from and treatment of kidney failure, however, its role in the protection of the heart from ischemia and reperfusion (I\/R) has not been investigated. This study investigated the antioxidant and anti-inflammatory effects of Gum Arabic (GA) in the protection of the heart against ischemia\/reperfusion (I\/R) injury. Langendorff-perfused Wistar rat hearts were divided into seven groups. One group which was subjected to I\/R with no other treatment served as the control group. The second group was subjected to buffer perfusion with no ischemia (sham group). The third group was perfused with GA in the absence of ischemia (sham\u2009+\u2009GA). The rest of the hearts were isolated from rats that had been treated with GA for 4 or 2\u00a0weeks in the drinking water, or GA that had been infused intravenously 2\u00a0h before sacrifice or added to perfusion buffer at reperfusion. Hemodynamics data were digitally computed; infarct size was measured using 2,3,5-triphenyltetrazolium chloride (TTC) staining and cardiomyocyte injury was assessed by quantifying creatine kinase (CK) and lactate dehydrogenase (LDH) enzymes. The total oxidants (TOS) and antioxidants (TAS), superoxide dismutase (SOD) and pro- and anti-inflammatory cytokines levels were estimated by ELISA. GA treatment for 2\u00a0weeks, 4\u00a0weeks or 2\u00a0hours before sacrifice resulted in a significant (P\u2009&lt;\u20090.05) improvement in cardiac hemodynamics and reduction in infarct size and cardiac enzyme levels compared to respective controls. However, GA administration at the time of reperfusion did not protect the hearts against I\/R injury. Furthermore, GA treatment decreased the pro-inflammatory and anti-inflammatory cytokines levels. The levels of TOS in the effluent were significantly decreased (P\u2009&lt;\u20090.05) and SOD levels were significantly (P\u2009&lt;\u20090.05) increased by GA administration. GA protected the heart against I\/R injury when administered for 2 or 4\u00a0weeks or when infused 2\u00a0hours before sacrifice. GA treatment decreased the total oxidants levels, the pro-inflammatory cytokines TNF-\u03b1, IL-1\u03b2 and IL-6 protein levels and increases SOD and anti-inflammatory cytokine IL-10 protein levels.<\/jats:p>","DOI":"10.1038\/s41598-022-22097-0","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T10:03:04Z","timestamp":1665741784000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Gum Arabic protects the rat heart from ischemia\/reperfusion injury through anti-inflammatory and antioxidant pathways"],"prefix":"10.1038","volume":"12","author":[{"given":"Eman","family":"Gouda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawzi","family":"Babiker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"22097_CR1","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.ijcard.2012.10.046","volume":"168","author":"JA Finegold","year":"2013","unstructured":"Finegold, J. 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