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Spatiotemporal gait parameters were assessed through a pressure-sensitive carpet. Statistical analysis consisted of a binary logistic regression (BLR) model, logistic curve-fit evaluated by a Chi-square goodness-of-fit-test, receiver operating characteristic models with area under the curves (AUC), and inverse BLR. Most discriminative gait parameter thresholds were observed in pace, gait cycle, and support gait domains. The most distinct gait conditions were preferred walking speed and semantic dual task. During preferred walking speed, the most significant gait parameter thresholds were stride length\u2009\u2264\u20091.02\u00a0m (sensitivity 0.93\/specificity 0.91\/AUC 0.96), gait velocity\u2009\u2264\u20090.83\u00a0m\/s (0.80\/0.91\/0.93), double support phase\u2009\u2265\u200927.0% (0.96\/0.76\/0.91), and stride length coefficient of variation\u2009\u2265\u20093.4% (0.93\/0.72\/0.90). In conclusion, the hypokinetic gait disorder in NPH can be quantitatively differentiated from gait patterns of the elderly population. In future studies, this approach may be useful to differentiate clinical entities with similar gait disorders utilizing instrumented gait analysis procedures.<\/jats:p>","DOI":"10.1038\/s41598-022-22692-1","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T11:02:46Z","timestamp":1667214166000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Quantification of pathological gait parameter thresholds of idiopathic normal pressure hydrocephalus patients in clinical gait analysis"],"prefix":"10.1038","volume":"12","author":[{"given":"Ken","family":"M\u00f6hwald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Wuehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Decker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric-Manuel","family":"Asch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Schenkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Illigens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Schniepp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"22692_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1056\/nejm196507152730301","volume":"273","author":"RD Adams","year":"1965","unstructured":"Adams, R. 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