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Despite the significant economic and public health consequences, only one drug is currently available for treatment of schistosomiasis, praziquantel. Thus, there is an urgent demand for new anthelmintic agents. Based on our continuous studies involving the chemical prospection of floristic biodiversity aiming to discover new bioactive compounds, this work reports the in vitro antiparasitic activity against\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    adult worms of neolignans\n                    <jats:italic>threo<\/jats:italic>\n                    -austrobailignan-6 and verrucosin, both isolated from\n                    <jats:italic>Saururus cernuus<\/jats:italic>\n                    L. (Saururaceae). These neolignans showed a significant in vitro schistosomicidal activity, with EC\n                    <jats:sub>50<\/jats:sub>\n                    values of 12.6\u201328.1\u00a0\u00b5M. Further analysis revealed a pronounced reduction in the number of\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    eggs. Scanning electron microscopy analysis revealed morphological alterations when schistosomes were exposed to either\n                    <jats:italic>threo<\/jats:italic>\n                    -austrobailignan-6 or verrucosin. These relevant antischistosomal properties were accompanied by low cytotoxicity potential against the animal (Vero) and human (HaCaT) cell lines, resulting in a high selectivity index. Considering the promising chemical and biological properties of\n                    <jats:italic>threo<\/jats:italic>\n                    -austrobailignan-6 and verrucosin, this research should be of interest to those in the area of neglected diseases and in particular antischistosomal drug discovery.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-23110-2","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T09:03:35Z","timestamp":1668157415000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Neolignans isolated from Saururus cernuus L. 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