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Common modalities do not offer lasting saffron preservation and it is urgent to develop novel packaging approaches from renewable resources and prevent packaging waste. Here, simultaneous decontamination and quality maintenance of saffron is demonstrated, for the first time, through the synergistic application of nano-clay-loaded carboxymethyl cellulose (CMC)\/polyvinyl alcohol (PVA) nanocomposites (CNCs) and cold plasmas (CP). Compared to the separate uses of CP and CMC\/PVA\/nano clay, our results confirm the synergies between CP and CMC\/PVA\/nano clay cause complete inactivation of <jats:italic>Escherichia coli<\/jats:italic> bacteria, while not significantly affecting the concentrations of the essential saffron components (safranal, crocin, and picrocrocin). Overall, the CP-treated CMC\/PVA\/nano clay fosters saffron preservation, through contamination removal and quality maintenance of the food product. The synergistic application of CP and CMC\/PVA\/nano clay thus represents a promising strategy for packaging, sterilization, and preservation of high-value food products.<\/jats:p>","DOI":"10.1038\/s41598-022-23284-9","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T11:02:46Z","timestamp":1667214166000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Synergistic cellulose-based nanocomposite packaging and cold plasma decontamination for extended saffron preservation"],"prefix":"10.1038","volume":"12","author":[{"given":"Maryam","family":"Amini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-2148","authenticated-orcid":false,"given":"Milad","family":"Rasouli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Ghoranneviss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Momeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostya Ken","family":"Ostrikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"23284_CR1","doi-asserted-by":"publisher","first-page":"103935","DOI":"10.1016\/j.foodqual.2020.103935","volume":"84","author":"A Szymkowiak","year":"2020","unstructured":"Szymkowiak, A., Guzik, P., Kulawik, P. & Zaj\u0105c, M. 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