{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:47:03Z","timestamp":1785793623610,"version":"3.56.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["grant No. 2018"],"award-info":[{"award-number":["grant No. 2018"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["grant No. 2018"],"award-info":[{"award-number":["grant No. 2018"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["grant No. 2018"],"award-info":[{"award-number":["grant No. 2018"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["grant No. 2018"],"award-info":[{"award-number":["grant No. 2018"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hospital de Cl\u00ednicas de Porto Alegre\/ CNPq","award":["Bolsa de Inicia\u00e7\u00e3o Cient\u00edfica (IC)"],"award-info":[{"award-number":["Bolsa de Inicia\u00e7\u00e3o Cient\u00edfica (IC)"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["grant No. 302688\/2017-0"],"award-info":[{"award-number":["grant No. 302688\/2017-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundo de Incentivo \u00e0 Pesquisa e Eventos (FIPE) from the Postgraduate Research Group at the Hospital de Cl\u00ednicas de Porto Alegre","award":["Project No. 2017-0329"],"award-info":[{"award-number":["Project No. 2017-0329"]}]},{"name":"Brazilian Innovation Agency (Financiadora de Estudos e Projetos","award":["process number 1245\/13"],"award-info":[{"award-number":["process number 1245\/13"]}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["17\/2551-0001 087-6"],"award-info":[{"award-number":["17\/2551-0001 087-6"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"crossref","award":["17\/2551-0001 476-6"],"award-info":[{"award-number":["17\/2551-0001 476-6"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fibromyalgia is a heterogenous primary pain syndrome whose severity has been associated with descending pain modulatory system (DPMS) function and functional connectivity (FC) between pain processing areas. The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism has been linked to vulnerability to chronic pain. In this cross-sectional imaging genetics study, we investigated fibromyalgia, the relationship between BDNF Val66Met heterozygous genotypes (Val\/Met), and the functional connectivity (FC) response pattern to acute pain stimulus in the motor (MC) and prefrontal (PFC) cortex assessed by near-infrared spectroscopy (fNIRS) before and after a cold pressor test utilizing water (0\u20131\u00a0\u00b0C). Also, we assessed the relationship between this genotype with the DPMS function and quality of life. We included 42 women (Val\/Val\u2009=\u200930; Val\/Met\u2009=\u200912) with fibromyalgia, ages 18\u201365. The MANCOVA comparing Val\/Met to Val\/Val genotypes showed higher \u0394FC between left(l)-PFC\u2014l-MC (\u03b2\u2009=\u20090.357, <jats:italic>p<\/jats:italic>\u2009=\u20090.048), l-PFC\u2014right(r)-PFC (\u03b2\u2009=\u20090.249, <jats:italic>p<\/jats:italic>\u2009=\u20090.012), l-PFC\u2014r-MC (\u03b2\u2009=\u20090.226, <jats:italic>p<\/jats:italic>\u2009=\u20090.022), and l-MC\u2014r-PFC (\u03b2\u2009=\u20090.260, <jats:italic>p<\/jats:italic>\u2009=\u20090.016). Val\/Met genotypes showed higher efficiency of the DPMS and lower disability due to pain. Here we show that fibromyalgia patients carrying the Val\/Met BDNF genotype presented an increased \u0394FC across MC and PFC in response to acute pain associated with differences in acute pain perception and fibromyalgia symptoms.<\/jats:p>","DOI":"10.1038\/s41598-022-23476-3","type":"journal-article","created":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T11:02:58Z","timestamp":1667732578000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Functional connectivity response to acute pain assessed by fNIRS is associated with BDNF genotype in fibromyalgia: an exploratory study"],"prefix":"10.1038","volume":"12","author":[{"given":"\u00c1lvaro","family":"de Oliveira Franco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"de Oliveira Venturini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Fernanda","family":"da Silveira Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rael Lopes","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Vicu\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Ramalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela","family":"Tomedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samara Machado","family":"Bruck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iraci L. S.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Fregni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolnei","family":"Caumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,6]]},"reference":[{"key":"23476_CR1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/j.pain.0000000000001384","volume":"160","author":"R Treede","year":"2019","unstructured":"Treede, R. et al. Chronic pain as a symptom or a disease: The IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11). Pain 160, 19\u201327 (2019).","journal-title":"Pain"},{"key":"23476_CR2","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1001\/jama.2014.3266","volume":"311","author":"D Clauw","year":"2014","unstructured":"Clauw, D. Fibromyalgia. JAMA 311, 1547 (2014).","journal-title":"JAMA"},{"key":"23476_CR3","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.jpain.2018.10.008","volume":"20","author":"L Arnold","year":"2019","unstructured":"Arnold, L. et al. AAPT diagnostic criteria for fibromyalgia. J. Pain 20, 611\u2013628 (2019).","journal-title":"J. Pain"},{"issue":"8","key":"23476_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11916-013-0356-5","volume":"17","author":"L Queiroz","year":"2013","unstructured":"Queiroz, L. Worldwide epidemiology of fibromyalgia. Curr. Pain Headache Rep. 17(8), 1\u20136 (2013).","journal-title":"Curr. Pain Headache Rep."},{"key":"23476_CR5","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","volume":"152","author":"C Woolf","year":"2011","unstructured":"Woolf, C. Central sensitization: Implications for the diagnosis and treatment of pain. Pain 152, S2\u2013S15 (2011).","journal-title":"Pain"},{"key":"23476_CR6","doi-asserted-by":"publisher","first-page":"E33","DOI":"10.1017\/SJP.2021.30","volume":"24","author":"M Mart\u00ednez","year":"2021","unstructured":"Mart\u00ednez, M. et al. Fibromyalgia as a heterogeneous condition: Subgroups of patients based on physical symptoms and cognitive-affective variables related to pain. Span. J. Psychol. 24, E33 (2021).","journal-title":"Span. J. Psychol."},{"key":"23476_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118742","volume":"247","author":"V Huynh","year":"2022","unstructured":"Huynh, V. et al. Descending pain modulatory efficiency in healthy subjects is related to structure and resting connectivity of brain regions. Neuroimage 247, 118742 (2022).","journal-title":"Neuroimage"},{"key":"23476_CR8","doi-asserted-by":"publisher","unstructured":"Goksan, S., Baxter, L., Moultrie, F., Duff, E., Hathway, G., Hartley, C. et al. The influence of the descending pain modulatory system on infant pain-related brain activity.\u00a0eLife.\u00a07, e37125 (2018). https:\/\/doi.org\/10.7554\/eLife.37125.","DOI":"10.7554\/eLife.37125"},{"key":"23476_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247629","volume":"17","author":"\u00c1 de Oliveira Franco","year":"2022","unstructured":"de Oliveira Franco, \u00c1. et al. Hyper-connectivity between the left motor cortex and prefrontal cortex is associated with the severity of dysfunction of the descending pain modulatory system in fibromyalgia. PLoS ONE 17, e0247629 (2022).","journal-title":"PLoS ONE"},{"key":"23476_CR10","doi-asserted-by":"crossref","unstructured":"Soldatelli, M., Siepmann, T., Illigens, B., Souza dos Santos, V., Lucena da S Torres, I., Fregni, F. et al. Mapping of predictors of the disengagement of the descending inhibitory pain modulation system in fibromyalgia: An exploratory study.\u00a0Brit. J. Pain.\u00a015, 221\u2013233 (2020).","DOI":"10.1177\/2049463720920760"},{"key":"23476_CR11","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.jpain.2017.10.007","volume":"19","author":"W Chang","year":"2018","unstructured":"Chang, W. et al. Altered primary motor cortex structure, organization, and function in chronic pain: A systematic review and meta-analysis. J. Pain 19, 341\u2013359 (2018).","journal-title":"J. Pain"},{"key":"23476_CR12","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.3389\/fnins.2019.01218","volume":"13","author":"M Zortea","year":"2019","unstructured":"Zortea, M. et al. Transcranial direct current stimulation to improve the dysfunction of descending pain modulatory system related to opioids in chronic non-cancer pain: An integrative review of neurobiology and meta-analysis. Front. Neurosci. 13, 1218 (2019).","journal-title":"Front. Neurosci."},{"key":"23476_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/2623161","volume":"2019","author":"E Gentile","year":"2019","unstructured":"Gentile, E., Ricci, K., Delussi, M., Brighina, F. & de Tommaso, M. Motor cortex function in fibromyalgia: A study by functional near-infrared spectroscopy. Pain Res. Treat. 2019, 1\u20137 (2019).","journal-title":"Pain Res. Treat."},{"key":"23476_CR14","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3389\/fnhum.2017.00270","volume":"11","author":"J Leite","year":"2017","unstructured":"Leite, J., Carvalho, S., Battistella, L., Caumo, W. & Fregni, F. Editorial: The role of primary motor cortex as a marker and modulator of pain control and emotional-affective processing. Front. Hum. Neurosci. 11, 270 (2017).","journal-title":"Front. Hum. Neurosci."},{"key":"23476_CR15","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1007\/s12035-018-1130-9","volume":"56","author":"W Ong","year":"2018","unstructured":"Ong, W., Stohler, C. & Herr, D. Role of the prefrontal cortex in pain processing. Mol. Neurobiol. 56, 1137\u20131166 (2018).","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"23476_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-79139-8","volume":"11","author":"D Donadel","year":"2021","unstructured":"Donadel, D., Zortea, M., Torres, I., Fregni, F. & Caumo, W. The mapping of cortical activation by near-infrared spectroscopy might be a biomarker related to the severity of fibromyalgia symptoms. Sci. Rep. 11(1), 1\u201314 (2021).","journal-title":"Sci. Rep."},{"key":"23476_CR17","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.brs.2009.12.003","volume":"3","author":"A Antal","year":"2010","unstructured":"Antal, A. et al. Brain-derived neurotrophic factor (BDNF) gene polymorphisms shape cortical plasticity in humans. Brain Stimul. 3, 230\u2013237 (2010).","journal-title":"Brain Stimul."},{"key":"23476_CR18","doi-asserted-by":"publisher","unstructured":"Miranda, M., Morici, J., Zanoni, M. & Bekinschtein, P. Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain.\u00a0Front. Cell. Neurosci.\u00a013, 363 (2019). https:\/\/doi.org\/10.3389\/fncel.2019.00363.","DOI":"10.3389\/fncel.2019.00363"},{"key":"23476_CR19","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.jad.2017.10.024","volume":"227","author":"M Zhao","year":"2018","unstructured":"Zhao, M. et al. BDNF Val66Met polymorphism, life stress and depression: A meta-analysis of gene-environment interaction. J. Affect. Disord. 227, 226\u2013235 (2018).","journal-title":"J. Affect. Disord."},{"issue":"1","key":"23476_CR20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0001-8","volume":"6","author":"S Wei","year":"2016","unstructured":"Wei, S. et al. The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea. Sci. Rep. 6(1), 1\u201311 (2016).","journal-title":"Sci. Rep."},{"key":"23476_CR21","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1186\/1744-8069-10-46","volume":"10","author":"S Zanette","year":"2014","unstructured":"Zanette, S. et al. Higher serum S100B and BDNF levels are correlated with a lower pressure-pain threshold in fibromyalgia. Mol. Pain. 10, 1744\u20138069 (2014).","journal-title":"Mol. Pain."},{"key":"23476_CR22","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.neuroimage.2005.08.065","volume":"29","author":"T Huppert","year":"2006","unstructured":"Huppert, T., Hoge, R., Diamond, S., Franceschini, M. & Boas, D. A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans. Neuroimage 29, 368\u2013382 (2006).","journal-title":"Neuroimage"},{"key":"23476_CR23","first-page":"3","volume":"9","author":"N Naseer","year":"2015","unstructured":"Naseer, N. & Hong, K. fNIRS-based brain-computer interfaces: A review. Front. Hum. Neurosci. 9, 3 (2015).","journal-title":"Front. Hum. Neurosci."},{"key":"23476_CR24","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.semarthrit.2016.08.012","volume":"46","author":"F Wolfe","year":"2016","unstructured":"Wolfe, F. et al. 2016 Revisions to the 2010\/2011 fibromyalgia diagnostic criteria. Semin. Arthritis Rheum. 46, 319\u2013329 (2016).","journal-title":"Semin. Arthritis Rheum."},{"key":"23476_CR25","doi-asserted-by":"publisher","first-page":"662","DOI":"10.3389\/fnins.2019.00662","volume":"13","author":"G Beltran Serrano","year":"2019","unstructured":"Beltran Serrano, G. et al. Comparison of hypnotic suggestion and transcranial direct-current stimulation effects on pain perception and the descending pain modulating system: A crossover randomized clinical trial. Front. Neurosci. 13, 662 (2019).","journal-title":"Front. Neurosci."},{"key":"23476_CR26","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.pain.2006.06.028","volume":"126","author":"M Koltzenburg","year":"2006","unstructured":"Koltzenburg, M., Pokorny, R., Gasser, U. & Richarz, U. Differential sensitivity of three experimental pain models in detecting the analgesic effects of transdermal fentanyl and buprenorphine. Pain 126, 165\u2013174 (2006).","journal-title":"Pain"},{"key":"23476_CR27","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3390\/a11050073","volume":"11","author":"H Santosa","year":"2018","unstructured":"Santosa, H., Zhai, X., Fishburn, F. & Huppert, T. The NIRS Brain AnalyzIR Toolbox. Algorithms 11, 73 (2018).","journal-title":"Algorithms"},{"key":"23476_CR28","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-9510-6_21","author":"M Cope","year":"1988","unstructured":"Cope, M. et al. Methods of quantitating cerebral near infrared spectroscopy data. Oxygen Transport to Tissue. X https:\/\/doi.org\/10.1007\/978-1-4615-9510-6_21 (1988).","journal-title":"Oxygen Transport to Tissue. X"},{"key":"23476_CR29","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/BF02447083","volume":"26","author":"M Cope","year":"1988","unstructured":"Cope, M. & Delpy, D. System for long-term measurement of cerebral blood and tissue oxygenation on newborn infants by near infra-red transillumination. Med. Biol. Eng. Compu. 26, 289\u2013294 (1988).","journal-title":"Med. Biol. Eng. Compu."},{"key":"23476_CR30","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1152\/jappl.2001.90.5.1657","volume":"90","author":"Y Hoshi","year":"2001","unstructured":"Hoshi, Y., Kobayashi, N. & Tamura, M. Interpretation of near-infrared spectroscopy signals: A study with a newly developed perfused rat brain model. J. Appl. Physiol. 90, 1657\u20131662 (2001).","journal-title":"J. Appl. Physiol."},{"key":"23476_CR31","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1006\/nimg.2002.1227","volume":"17","author":"G Strangman","year":"2002","unstructured":"Strangman, G., Culver, J., Thompson, J. & Boas, D. A quantitative comparison of simultaneous BOLD fMRI and NIRS recordings during functional brain activation. Neuroimage 17, 719\u2013731 (2002).","journal-title":"Neuroimage"},{"issue":"1","key":"23476_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep16438","volume":"5","author":"T Zama","year":"2015","unstructured":"Zama, T. & Shimada, S. Simultaneous measurement of electroencephalography and near-infrared spectroscopy during voluntary motor preparation. Sci. Rep. 5(1), 1\u20139 (2015).","journal-title":"Sci. Rep."},{"key":"23476_CR33","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1364\/BOE.4.001366","volume":"4","author":"J Barker","year":"2013","unstructured":"Barker, J., Aarabi, A. & Huppert, T. Autoregressive model based algorithm for correcting motion and serially correlated errors in fNIRS. Biomed. Opt. Express 4, 1366 (2013).","journal-title":"Biomed. Opt. Express"},{"key":"23476_CR34","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.3.1.010401","volume":"3","author":"T Huppert","year":"2016","unstructured":"Huppert, T. Commentary on the statistical properties of noise and its implication on general linear models in functional near-infrared spectroscopy. Neurophotonics. 3, 010401 (2016).","journal-title":"Neurophotonics."},{"key":"23476_CR35","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.3.3.031410","volume":"3","author":"J Barker","year":"2016","unstructured":"Barker, J., Rosso, A., Sparto, P. & Huppert, T. Correction of motion artifacts and serial correlations for real-time functional near-infrared spectroscopy. Neurophotonics. 3, 031410 (2016).","journal-title":"Neurophotonics."},{"key":"23476_CR36","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.22.5.055002","volume":"22","author":"H Santosa","year":"2017","unstructured":"Santosa, H., Aarabi, A., Perlman, S. & Huppert, T. Characterization and correction of the false-discovery rates in resting state connectivity using functional near-infrared spectroscopy. J. Biomed. Opt. 22, 055002 (2017).","journal-title":"J. Biomed. Opt."},{"key":"23476_CR37","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1590\/S0482-50042006000100006","volume":"46","author":"A Marques","year":"2006","unstructured":"Marques, A. et al. Valida\u00e7\u00e3o da vers\u00e3o brasileira do fibromyalgia impact questionnaire (FIQ). Rev. Bras. Reumatol. 46, 24\u201331 (2006).","journal-title":"Rev. Bras. Reumatol."},{"key":"23476_CR38","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1590\/S1516-44462000000300003","volume":"22","author":"P Amorim","year":"2000","unstructured":"Amorim, P. Mini International Neuropsychiatric Interview (MINI): Valida\u00e7\u00e3o de entrevista breve para diagn\u00f3stico de transtornos mentais. Rev. Bras. Psiquiatr. 22, 106\u2013115 (2000).","journal-title":"Rev. Bras. Psiquiatr."},{"key":"23476_CR39","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.rbp.2012.03.005","volume":"34","author":"M Gomes-Oliveira","year":"2012","unstructured":"Gomes-Oliveira, M., Gorenstein, C., Neto, F., Andrade, L. & Wang, Y. Validation of the Brazilian Portuguese version of the beck depression inventory-II in a community sample. Rev. Bras. Psiquiatr. 34, 389\u2013394 (2012).","journal-title":"Rev. Bras. Psiquiatr."},{"key":"23476_CR40","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.2147\/JPR.S131479","volume":"10","author":"W Caumo","year":"2017","unstructured":"Caumo, W. et al. The Central Sensitization Inventory validated and adapted for a Brazilian population: Psychometric properties and its relationship with brain-derived neurotrophic factor. J. Pain Res. 10, 2109\u20132122 (2017).","journal-title":"J. Pain Res."},{"key":"23476_CR41","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.sleep.2010.04.020","volume":"12","author":"A Bertolazi","year":"2011","unstructured":"Bertolazi, A. et al. Validation of the Brazilian Portuguese version of the pittsburgh sleep quality index. Sleep Med. 12, 70\u201375 (2011).","journal-title":"Sleep Med."},{"key":"23476_CR42","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1111\/j.1526-4637.2012.01492.x","volume":"13","author":"F Sehn","year":"2012","unstructured":"Sehn, F. et al. Cross-cultural adaptation and validation of the Brazilian Portuguese version of the pain catastrophizing scale. Pain Med. 13, 1425\u20131435 (2012).","journal-title":"Pain Med."},{"key":"23476_CR43","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.neuroimage.2010.01.035","volume":"53","author":"K Bigos","year":"2010","unstructured":"Bigos, K. & Weinberger, D. Imaging genetics\u2014days of future past. Neuroimage 53, 804\u2013809 (2010).","journal-title":"Neuroimage"},{"key":"23476_CR44","doi-asserted-by":"publisher","first-page":"5717","DOI":"10.1113\/jphysiol.2008.159905","volume":"586","author":"B Cheeran","year":"2008","unstructured":"Cheeran, B. et al. A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS. J. Physiol. 586, 5717\u20135725 (2008).","journal-title":"J. Physiol."},{"key":"23476_CR45","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","volume":"112","author":"M Egan","year":"2003","unstructured":"Egan, M. et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257\u2013269 (2003).","journal-title":"Cell"},{"key":"23476_CR46","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/nn1699","volume":"9","author":"J Kleim","year":"2006","unstructured":"Kleim, J. et al. BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex. Nat. Neurosci. 9, 735\u2013737 (2006).","journal-title":"Nat. Neurosci."},{"key":"23476_CR47","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.jpain.2012.05.014","volume":"13","author":"C Di Lorenzo","year":"2012","unstructured":"Di Lorenzo, C. et al. The Val66Met polymorphism of the BDNF gene influences trigeminal pain-related evoked responses. J. Pain 13, 866\u2013873 (2012).","journal-title":"J. Pain"},{"key":"23476_CR48","doi-asserted-by":"publisher","unstructured":"Betancur, D., Tarrag\u00f3, M., Torres, I., Fregni, F. & Caumo, W. Central post-stroke pain: An integrative review of somatotopic damage, clinical symptoms, and neurophysiological measures.\u00a0Front. Neurol.\u00a012, 678198 (2021).https:\/\/doi.org\/10.3389\/fneur.2021.678198.","DOI":"10.3389\/fneur.2021.678198"},{"key":"23476_CR49","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013477","volume":"98","author":"A Brietzke","year":"2019","unstructured":"Brietzke, A. et al. Potency of descending pain modulatory system is linked with peripheral sensory dysfunction in fibromyalgia. Medicine 98, e13477 (2019).","journal-title":"Medicine"},{"key":"23476_CR50","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.jpain.2019.06.013","volume":"21","author":"A Brietzke","year":"2020","unstructured":"Brietzke, A. et al. Large treatment effect with extended home-based transcranial direct current stimulation over dorsolateral prefrontal cortex in fibromyalgia: A proof of concept sham-randomized clinical study. J. Pain 21, 212\u2013224 (2020).","journal-title":"J. Pain"},{"issue":"1","key":"23476_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-30127-z","volume":"8","author":"V Santos","year":"2018","unstructured":"Santos, V. et al. Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial. Sci. Rep. 8(1), 1\u201311 (2018).","journal-title":"Sci. Rep."},{"key":"23476_CR52","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1056\/NEJMoa0801119","volume":"359","author":"J Han","year":"2008","unstructured":"Han, J. et al. Brain-derived neurotrophic factor and obesity in the WAGR syndrome. N. Engl. J. Med. 359, 918\u2013927 (2008).","journal-title":"N. Engl. J. Med."},{"key":"23476_CR53","doi-asserted-by":"publisher","unstructured":"da Silveira Alves, C., Caumo, W., Silvestri, J., Zortea, M., dos Santos, V., Cardoso, D. et al. Pain catastrophizing is associated with the Val66Met polymorphism of the brain-derived neurotrophic factor in fibromyalgia.\u00a0Adv. Rheumatol.\u00a060(1), 39 (2020). https:\/\/doi.org\/10.1186\/s42358-020-00141-9.","DOI":"10.1186\/s42358-020-00141-9"},{"key":"23476_CR54","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/mp.2009.24","volume":"15","author":"T Petryshen","year":"2009","unstructured":"Petryshen, T. et al. Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Mol. Psychiatry 15, 810\u2013815 (2009).","journal-title":"Mol. Psychiatry"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-23476-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-23476-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-23476-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T01:02:53Z","timestamp":1667869373000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-23476-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,6]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["23476"],"URL":"https:\/\/doi.org\/10.1038\/s41598-022-23476-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,6]]},"assertion":[{"value":"14 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18831"}}