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Our aim was to assess the impact of contrasting feeding regimes in bull calves during the first 12\u00a0weeks of life on the testes transcriptome and proteome. Holstein\u2013Friesian bull calves were offered either a high (HI) or moderate (MOD) plane of nutrition, designed to support target growth rates of 1.0 and 0.5\u00a0kg\/day, respectively. At 12\u00a0weeks of age all calves were euthanized, testicular parenchyma sampled, and global transcriptome (miRNAseq and mRNAseq) and proteome analyses undertaken. Bioinformatic analyses revealed 7 differentially expressed (DE) miRNA and 20 DE mRNA. There were no differentially abundant proteins between the two dietary groups. Integration of omics results highlighted a potential role for the cadherin gene,\n                    <jats:italic>CDH13<\/jats:italic>\n                    , in earlier reproductive development. Furthermore, co-regulatory network analysis of the proteomic data revealed CDH13 as a hub protein within a network enriched for processes related to insulin, IGF-1, androgen and Sertoli cell junction signalling pathways as well as cholesterol biosynthesis. Overall, results highlight a potential role for CDH13 in mediating earlier reproductive development as a consequence of enhanced early life nutrition in the bull calf.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-23743-3","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T07:16:07Z","timestamp":1682406967000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Early life nutrition affects the molecular ontogeny of testicular development in the young bull calf"],"prefix":"10.1038","volume":"13","author":[{"given":"Stephen","family":"Coen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Keogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat","family":"Lonergan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Fair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"23743_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1439-0531.2008.01177.x","volume":"43","author":"N Rawlings","year":"2008","unstructured":"Rawlings, N., Evans, A., Chandolia, R. & Bagu, E. 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