{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:51:21Z","timestamp":1790772681988,"version":"4.1.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Despite various intraoperative thermal strategies, core heat loss is considerable during liver transplantation and hypothermia is common. We tested whether forced-air prewarming prevents hypothermia during liver transplantation. Adult patients undergoing living donor liver transplantation were randomly assigned to non-prewarming group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920) or prewarming group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920). Patients in prewarming group underwent 30-min forced-air warming before anesthetic induction. During surgery, core temperature was measured in the pulmonary artery. The primary outcome was intraoperative hypothermia (&lt;\u200936.0\u00a0\u00b0C). The secondary outcomes included plasma lactate concentration. Intraoperative hypothermia risk was significantly lower in prewarming group than in non-prewarming group (60.0% vs. 95.0%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.020). The difference in hypothermia incidence between groups was greater in the post-induction phase (20.0% vs. 85.0%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001) than in the anhepatic or post-reperfusion phase, suggesting that prewarming mainly acts on preventing post-induction core-to-peripheral heat redistribution. Hypothermia duration was significantly shorter in prewarming group (60 [0\u2013221] min vs. 383 [108\u2013426] min,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.001). Lactate concentration decreased during 3\u00a0h after graft reperfusion in prewarming group, whereas it continuously increased in non-prewarming group (\u2212\u00a00.19 [\u2212\u00a00.48 to 0.13]\u00a0mmol\/L vs. 1.17 [3.31\u20130.77]\u00a0mmol\/L,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.034). In conclusion, forced-air prewarming decreases the incidence and duration of intraoperative hypothermia with potential clinical benefit while mainly acting by preventing the core-to-peripheral heat redistribution.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Clinical trial registration<\/jats:italic>\n                    : Registered at the Clinical Research Information Service (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/cris.nih.go.kr\">https:\/\/cris.nih.go.kr<\/jats:ext-link>\n                    , [KCT0003230]) on 01\/10\/2018.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-23930-2","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T06:03:05Z","timestamp":1680760985000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Forced-air prewarming prevents hypothermia during living donor liver transplantation: a randomized controlled trial"],"prefix":"10.1038","volume":"13","author":[{"given":"Eun Jung","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangbin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sooyeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ah","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin S.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Sook","family":"Gwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaab Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"key":"23930_CR1","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.transproceed.2013.11.091","volume":"46","author":"S Han","year":"2014","unstructured":"Han, S. et al. 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The study subjects were liver transplant recipients undergoing living donor liver transplantation (LDLT). All recipients in the current study received a graft harvested in our hospital. The living donor selection process was rigorously performed according to our national and institutional medical and ethical protocols. In South Korea, all living donors should obtain official approval from a national institute named Korean Network for Organ Sharing (KONOS) prior to donation and one of the key national policies is that organ donation is allowed for offspring, spouse, and parents in principle. All of the 40 recipients included in the current study were related to the donors. Informed consent for liver donation was obtained for all living donors prior to donation hepatectomy and LT.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3713"}}